A5100768759- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Multiple Myeloma Research and Treatments
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Cardiovascular Function and Risk Factors
- Gastric Cancer Management and Outcomes
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Hepatitis B Virus Studies
- Circular RNAs in diseases
- Uterine Myomas and Treatments
- Tuberculosis Research and Epidemiology
- Tracheal and airway disorders
- MRI in cancer diagnosis
- Systemic Lupus Erythematosus Research
- Histone Deacetylase Inhibitors Research
Boston Children's Hospital
2023-2025
Xiamen Tobacco Industry (China)
2024
China Tobacco
2024
Sun Yat-sen University
2015-2024
Sun Yat-sen University Cancer Center
2015-2024
First Affiliated Hospital of Zhengzhou University
2016-2024
Nanjing Medical University
2013-2024
East China University of Science and Technology
2024
Second Affiliated Hospital of Zhejiang University
2023-2024
Capital Medical University
2006-2024
Estrogen receptor α (ESR1) mutations found in metastatic breast cancer (MBC) promote ligand-independent activation and resistance to estrogen-deprivation therapy laboratory models. The prevalence of these their potential impact on clinical outcomes has not been established.To determine the ESR1 (Y537S D538G) estrogen (ER)-positive MBC whether mutation is associated with inferior outcomes.From December 16, 2014, August 26, 2015, we analyzed cell-free DNA (cfDNA) from baseline plasma samples...
Cachexia is a debilitating condition characterized by extreme skeletal muscle wasting that contributes significantly to morbidity and mortality. Efforts elucidate the underlying mechanisms of loss have predominantly focused on events intrinsic myofiber. In contrast, less regard has been given potential contributory factors outside fiber within microenvironment. tumor-bearing mice patients with pancreatic cancer, we found cachexia was associated type damage resulting in activation both...
Significance MicroRNAs (miRNAs) are small, noncoding RNAs regulating gene expression. The aberrant expression of miRNAs is commonly associated with cancer. can be packaged in exosomes/microvesicles secreted by the cells and involved cell-to-cell signaling communication; tumor-secreted promote tumor spread growth surrounding microenvironment. Apoptosis reported to take place wasting muscle cancer cachexia, a debilitating syndrome multiple types cancer, although mechanism remains elusive. This...
Abstract Although oxaliplatin-based chemotherapy has been effective in the treatment of hepatocellular carcinoma (HCC), primary or acquired resistance to oxaliplatin remains a major challenge clinic. Through functional screening using CRISPR/Cas9 activation library, transcriptomic profiling clinical samples, and validation vitro vivo, we identify PRMT3 as key driver resistance. Mechanistically, PRMT3-mediated oxaliplatin-resistance is part dependent on methylation IGF2BP1 at R452, which...
This study aimed to investigate the potential association between dietary live microbe intake and sarcopenia.
Purpose Early-stage hepatocellular carcinoma (E-HCC) is being diagnosed increasingly, and in one half of patients, recurrence will develop. Thus, it urgent to identify recurrence-related markers. We investigated the effectiveness CpG methylation predicting for patients with E-HCCs. Patients Methods In total, 576 E-HCC from four independent centers were sorted by three phases. discovery phase, 66 tumor samples analyzed using Illumina Methylation 450k Beadchip. Two algorithms, Least Absolute...
Whether microwave ablation (MWA) challenges the standard role of radiofrequency (RFA) in treating early-stage hepatocellular carcinoma (HCC) remains unclear.To compare efficacy MWA vs RFA for primary HCC within Milan criteria.From January 2002 to 2017, oncological outcomes after (126 patients) and (436 were analysed by propensity score matching.Before matching, overall patients, resulted similar 5-year survival (80.1% 75.8%, P = 0.190) but better recurrence-free (28.1% 19.6%, 0.036). For...
The sweet rhizomes of Polygonatum cyrtonema are widely used as a tonic and functional food. A sensitive rapid analytical method was developed for simultaneous identification dynamic analysis saccharides during steam processing in P. using HPLC⁻QTOF⁻MS/MS. Fructose, sorbitol, glucose, galactose, sucrose, 1-kestose were identified, well large number oligosaccharides constituted fructose units through β-(2→1) or β-(2→6). Polysaccharides decomposed to monosaccharides steaming process, since the...
Angiogenesis, one of the hallmarks cancer, is essential for both tumor growth and metastasis. However, its molecular mechanisms in hepatocellular carcinoma (HCC) are largely unknown. Here, we report role HOXA5 angiogenesis HCC. Methods: The expression miR-130b-3p was determined by qRT-PCR immunohistochemistry, respectively. Capillary tube formation assay, chicken chorioallantoic membrane subcutaneous xenograft experiments were performed to investigate miR-130-3p HOXA5. Luciferase reporter...
Abstract Transarterial chemoembolization (TACE) is the major treatment for advanced hepatocellular carcinoma (HCC), but it may cause hypoxic environment, leading to rapid progression after treatment. Here, using high‐throughput sequencing on different models, S100 calcium binding protein A9 (S100A9) identified as a key oncogene involved in post‐TACE progression. Depletion or pharmacologic inhibition of S100A9 significantly dampens growth and metastatic ability HCC. Mechanistically, TACE...
Background: The optimal subsequent management for patients with initially unresectable hepatocellular carcinoma (uHCC) who have achieved complete response (CR) following conversion therapy remains unclear. This study aims to evaluate the feasibility and outcomes of watch-and-wait (W-W) strategy versus surgical resection (SR) these patients. Materials Methods: retrospective reviewed uHCC underwent employing transarterial therapies combined or without systemic therapies. Radiologic CR (rCR),...
The positive photoconductive (PPC) effect is a well-established primary detection mechanism employed by photodetectors. In contrast, the negative (NPC) not extensively investigated thus far, and research on NPC still in its early stage. Herein, quaternary van der Waals material, AgBiP
Background Classical NF-κB signaling functions as a negative regulator of skeletal myogenesis through potentially multiple mechanisms. The inhibitory actions TNFα on muscle differentiation are mediated in part sustained activity. In dystrophic muscles, activity is compartmentalized to myofibers inhibit regeneration by limiting the number myogenic progenitor cells. This regulation coincides with elevated levels derived that also under IKKβ and control. Methodology/Principal Findings Based...
Inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified (mGPS), Index (PI), Nutritional (PNI), neutrophil to lymphocyte ratio (NLR), platelet (PLR), monocyte (LMR) and systemic immune-inflammation index (SII), are correlated with survival of hepatocellular carcinoma (HCC) patients, while remain unclear for recurrent HCC. This study aimed compare value inflammation-based scores post-recurrence (PRS) in patients early HCC (ErHCC, within 2 years after...
To evaluate whether this conversion rate to resectability could be increased when patients are treated with transarterial chemoembolization and hepatic arterial infusion chemotherapy (TACE-HAIC) using oxaliplatin plus fluorouracil/leucovorin.Conventional TACE (c-TACE) is a common regimen for initially unresectable hepatocellular carcinoma (HCC), which converts curative-intent resection in about 10% of those patients. It urgent need investigated better patients.The data 83 HCC were examined,...
viable tumors post-TACE were significantly increased compared with pre-TACE (P = 0.005, 0.012, 0.035 and respectively).CONCLUSION: Changes in CT perfusion parameters of are correlated different responses HCC to TACE.Therefore, imaging is a feasible technique for monitoring response TACE.
Abstract Competitive inhibitors of acetyl-lysine binding to the bromodomains BET (bromodomain and extra terminal) family are being developed for treatment solid hematologic malignancies. The function member BRD4 at enhancers/superenhancers has been shown sustain signal-dependent or pathogenic gene expression programs. Here, hypothesis was tested that transcription factor drivers castration-resistant prostate cancer (CRPC) clinical progression, including androgen receptor (AR), critically...
Abstract Background Patients with hepatocellular carcinoma (HCC) undergoing surgical resection still have a high 5‐year recurrence rate (~ 60%). With the development of laparoscopic hepatectomy (LH), few studies compared efficacy between LH and traditional approach on HCC. The objective this study was to establish nomogram evaluate risk in HCC patients who underwent LH. Methods clinical data 432 patients, pathologically diagnosed HCC, as initial treatment had margin > 1 cm were collected....
The notable lack of intrinsic p-type 2D layered semiconductors has hindered the engineering devices for complementary metal oxide (CMOSs). Herein, a novel quaternary semiconductor, CuBiP2 Se6 atomic layers, is introduced into family. semiconductor displays high work function 5.26 eV, moderate hole mobility 1.72 cm2 V-1 s-1 , and an ultrahigh on/off current exceeding 106 at room temperature. To date, eV highest work-function recorded in materials, indicating ultrastable behavior ....