A5046183867- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Mechanisms and Therapy
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Protein Tyrosine Phosphatases
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease and Transplantation
- Liver physiology and pathology
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2016-2025
University of Colorado Denver
2023-2024
University of Colorado Cancer Center
2023-2024
State Key Laboratory of Oncology in South China
2009-2024
Hoa Sen University
2023
Yahoo (United Kingdom)
2023
The University of Texas MD Anderson Cancer Center
2014-2017
University of Hong Kong
2017
The First Affiliated Hospital, Sun Yat-sen University
2017
Genome-wide mutational signatures of the group 1 carcinogen aristolochic acid are observed in urothelial cancers and liver from Asia.
The long-term survival of patients with hepatocellular carcinoma (HCC) portal vein tumour thrombus (PVTT) is poor. Systemic therapy, transcatheter arterial chemoembolization (TACE), and hepatic artery infusion chemotherapy are widely used in HCC PVTT. This study aims to explore the efficacy combining systemic therapy transarterial-based
Purpose Early-stage hepatocellular carcinoma (E-HCC) is being diagnosed increasingly, and in one half of patients, recurrence will develop. Thus, it urgent to identify recurrence-related markers. We investigated the effectiveness CpG methylation predicting for patients with E-HCCs. Patients Methods In total, 576 E-HCC from four independent centers were sorted by three phases. discovery phase, 66 tumor samples analyzed using Illumina Methylation 450k Beadchip. Two algorithms, Least Absolute...
Esophageal cancer is one of the most lethal cancers worldwide with poor survival and limited therapeutic options. The discovery microRNAs created a new milestone in research. miR-377 located chromosome region 14q32, which frequently deleted esophageal squamous cell carcinoma (ESCC), but biological functions, clinical significance implication ESCC are largely unknown. In this study, we found that expression was significantly downregulated tumor tissue serum patients ESCC. Both levels were...
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies resistant to current chemotherapies or radiotherapies, which makes it urgent identify new therapeutic targets for HCC. In this study, we found that checkpoint kinase 1 (CHK1) was frequently overexpressed and correlated with poor clinical outcome in patients We further showed CHK1 inhibitor GÖ6976 capable sensitizing HCC cells cisplatin, indicating may have oncogenic function phosphorylated tumor suppressor spleen...
Whether microwave ablation (MWA) challenges the standard role of radiofrequency (RFA) in treating early-stage hepatocellular carcinoma (HCC) remains unclear.To compare efficacy MWA vs RFA for primary HCC within Milan criteria.From January 2002 to 2017, oncological outcomes after (126 patients) and (436 were analysed by propensity score matching.Before matching, overall patients, resulted similar 5-year survival (80.1% 75.8%, P = 0.190) but better recurrence-free (28.1% 19.6%, 0.036). For...
Angiogenesis, one of the hallmarks cancer, is essential for both tumor growth and metastasis. However, its molecular mechanisms in hepatocellular carcinoma (HCC) are largely unknown. Here, we report role HOXA5 angiogenesis HCC. Methods: The expression miR-130b-3p was determined by qRT-PCR immunohistochemistry, respectively. Capillary tube formation assay, chicken chorioallantoic membrane subcutaneous xenograft experiments were performed to investigate miR-130-3p HOXA5. Luciferase reporter...
Rationale: Hepatectomy and adjuvant chemotherapy after resection of colorectal liver metastases (CRLM) may improve survival, however, patients which benefit cannot currently be identified. Postoperative circulating tumor DNA (ctDNA) analysis can detect minimal residual disease (MRD) predict the prognosis efficacy chemotherapy. Our study aims to determine impact serial ctDNA outcome among undergoing CRLM. Methods: Between May 2018 October 2019, 91 CRLM were prospectively enrolled. Whole exome...
Abstract Transarterial chemoembolization (TACE) is the major treatment for advanced hepatocellular carcinoma (HCC), but it may cause hypoxic environment, leading to rapid progression after treatment. Here, using high‐throughput sequencing on different models, S100 calcium binding protein A9 (S100A9) identified as a key oncogene involved in post‐TACE progression. Depletion or pharmacologic inhibition of S100A9 significantly dampens growth and metastatic ability HCC. Mechanistically, TACE...
Background: The optimal subsequent management for patients with initially unresectable hepatocellular carcinoma (uHCC) who have achieved complete response (CR) following conversion therapy remains unclear. This study aims to evaluate the feasibility and outcomes of watch-and-wait (W-W) strategy versus surgical resection (SR) these patients. Materials Methods: retrospective reviewed uHCC underwent employing transarterial therapies combined or without systemic therapies. Radiologic CR (rCR),...
MicroRNAs (miRNAs) play important roles in the development and progression of cancer. The aim this study is to identify miRNA expression signatures hepatocellular carcinoma delineate their clinical significance for carcinoma.Patients with carcinoma, undergoing hepatectomy were randomly divided into training set (60 patients) test (50 patients). Other 56 patients used as an independent cohort. levels detected by microarray verified quantitative real-time reverse transcription-PCR (qRT-PCR).A...
Abstract We have previously isolated an oncogene EIF5A2 (eukaryotic initiation factor 5A2) from a frequently amplified region at 3q of primary ovarian cancer cell line, and demonstrated its impact on prognosis in human cancer. Amplification chromosome has also been detected non–small lung (NSCLC), however, abnormalities clinicopathologic significance NSCLC haven't studied. In our study, the methods immunohistochemistry fluorescence situ hybridization were utilized to examine protein...
Inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified (mGPS), Index (PI), Nutritional (PNI), neutrophil to lymphocyte ratio (NLR), platelet (PLR), monocyte (LMR) and systemic immune-inflammation index (SII), are correlated with survival of hepatocellular carcinoma (HCC) patients, while remain unclear for recurrent HCC. This study aimed compare value inflammation-based scores post-recurrence (PRS) in patients early HCC (ErHCC, within 2 years after...
To evaluate whether this conversion rate to resectability could be increased when patients are treated with transarterial chemoembolization and hepatic arterial infusion chemotherapy (TACE-HAIC) using oxaliplatin plus fluorouracil/leucovorin.Conventional TACE (c-TACE) is a common regimen for initially unresectable hepatocellular carcinoma (HCC), which converts curative-intent resection in about 10% of those patients. It urgent need investigated better patients.The data 83 HCC were examined,...
The enhancer of zeste homolog 2 (EZH2), a known repressor gene transcription, has been reported to be associated with biological malignancy in several cancers. potential oncogenic role EZH2 and its clinical/prognostic significance, however, esophageal squamous cell carcinoma (ESCC) are unclear. In this study, the methods immunohistochemistry fluorescence in-situ hybridization were used examine protein expression amplification 98 pretreatment biopsy specimens ESCC who received definitive...
Metastasis-associated in colon cancer-1 (MACC1) is a newly identified gene that plays role cancer metastasis through upregulation of c-MET proto-oncogene (c-MET). However, the value MACC1 as potential biomarker for hepatocellular carcinoma (HCC) remains unknown.MACC1 mRNA expression 128 HCC tissues was examined by quantitative polymerase chain reaction. To show correlation and c-MET, also analysed.MACC1 more highly expressed than non-HCC (P = 0.009). High significantly increased cases with...