A5046963739- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Protease and Inhibitor Mechanisms
- Silk-based biomaterials and applications
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Appendicitis Diagnosis and Management
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- MRI in cancer diagnosis
- RNA modifications and cancer
- Colorectal Cancer Treatments and Studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Liver physiology and pathology
Guangzhou Medical University
2014-2024
Guangzhou Medical University Cancer Hospital
2008-2024
Shanghai Jiao Tong University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Ruijin Hospital
2011-2022
Cancer Hospital and Research Institute
2020
Guangdong Academy of Medical Sciences
2020
Guangdong Provincial People's Hospital
2020
Shantou University
2020
Shantou University Medical College
2020
<b>Objectives</b> To assess the compliance of Asian intensive care units and hospitals to Surviving Sepsis Campaign's resuscitation management bundles. Secondary objectives were evaluate impact on mortality organisational characteristics that associated with higher compliance. <b>Design</b> Prospective cohort study. <b>Setting</b> 150 in 16 countries. <b>Participants</b> 1285 adult patients severe sepsis admitted these July 2009. The participating centres, patients' baseline characteristics,...
Purpose Early-stage hepatocellular carcinoma (E-HCC) is being diagnosed increasingly, and in one half of patients, recurrence will develop. Thus, it urgent to identify recurrence-related markers. We investigated the effectiveness CpG methylation predicting for patients with E-HCCs. Patients Methods In total, 576 E-HCC from four independent centers were sorted by three phases. discovery phase, 66 tumor samples analyzed using Illumina Methylation 450k Beadchip. Two algorithms, Least Absolute...
Sorafenib is the most recommended first‐line systemic therapy for advanced hepatocellular carcinoma (HCC). Yet there no clinically applied biomarker predicting sorafenib response. We have demonstrated that a vascular pattern, named VETC (Vessels Encapsulate Tumor Clusters), facilitates release of whole tumor clusters into bloodstream; VETC‐mediated metastasis relies on but not migration and invasion cancer cells. In this study, we aimed to explore whether pattern could predict benefit. Two...
Hepatocellular carcinoma (HCC) has a dismal long-term outcome. We aimed to construct multi-gene model for prognosis prediction inform HCC management. The cancer-specific differentially expressed genes (DEGs) were identified using RNA-seq data of paired tumor and normal tissue. A prognostic signature was built by LASSO regression analysis. Gene get enrichment analysis (GSEA) performed further understand the underlying molecular mechanisms. 10-gene constructed stratify TCGA ICGC cohorts into...
CLDN6 is not only a marker of hepatocellular carcinoma but also therapeutic target by promoting sorafenib resistance and lineage plasticity.
Abstract The high incidence of recurrence and the poor prognosis hepatocellular carcinoma ( HCC ) necessitate discovery new predictive markers invasion prognosis. In this study, we evaluated expression pattern two members a novel oncogene family, Musashi1 MSI 1) Musashi2 2) in 40 normal hepatic tissue specimens, 149 specimens their adjacent non‐tumourous tissues. We observed that 1 2 were significantly up‐regulated High levels detectable 37.6% (56/149) 49.0% (73/149) respectively, but rarely...
Abstract Background CKLF like MARVEL transmembrane domain containing 6 (CMTM6) has been associated with the development in many kinds of cancers. However, roles CMTM6 hepatocellular carcinoma (HCC) are largely unknown. Thus, present study aimed to investigate function HCC. Methods We analysed levels and functions using human HCC cell lines, paired adjacent non-tumorous tissues, a tissue microarray. expression was silenced short hairpin RNAs its overexpressed from lentivirus vector. mRNA...
Tumour lineage plasticity is an emerging hallmark of aggressive tumours. cells usually hijack developmental signalling pathways to gain cellular and evade therapeutic targeting. In the present study, secreted protein growth differentiation factor 1 (GDF1) found be closely associated with poor tumour differentiation. Overexpression GDF1 suppresses cell proliferation but strongly enhances dissemination metastasis. Ectopic expression can induce dedifferentiation hepatocellular carcinoma (HCC)...
Objective: The present study aimed to investigate the effectiveness of parenteral nutritional support with ω-3 PUFAs–based lipid emulsions in patients after liver resection. Methods: A total 119 were randomly assigned immunonutrition (IM) group (n = 59) and control 60). IM was continuously given Omegaven® 10% 100 mL/day rather than regular nutrition for five days postoperatively. Venous blood samples obtained from all subjects before surgery D1, D3 D7 surgery. Results: No significant...
Abstract The tumor microenvironment is a key determinant of cancer cell biology. complex mixture cells, stromal and proteins, extracellular matrix, oxygen tension, pH levels surrounding the cells that regulate progress. This study identified prognostic factors associated with hepatocellular carcinoma (HCC) MCT4 GLUT1 expression in HCC specimens. In this study, we analyzed tissue samples from 213 patients by immunohistochemical analyses tissues matched adjacent nonneoplastic quantitative...
To examine the feasibility of three-dimensional computed tomography (3D-CT) image fusion in facilitating assessment ablative margin (AM) after radiofrequency ablation (RFA) hepatocellular carcinoma (HCC).This study involved 75 patients with solitary HCC who underwent RFA. The AM was evaluated using 3D-CT fusion. All cases were categorized into two groups based on extent AM: Group A, sufficient obtained, which greater than or equal to 5 mm; B, lesion also ablated successfully, but a mm not...
Biomarkers based on immune context may guide prognosis prediction. T-cell inactivation, exclusion, or dysfunction could cause unfavorable tumor microenvironments, which affect immunotherapy and prognosis. However, none of the immuno-biomarkers reported to date can differentiate colorectal-cancer (CRC) patients. Thus, we aimed classify CRC patients according levels activation, in microenvironment. RNAseq data 618 from The Cancer Genome Atlas microarray 316 Gene Expression Omnibus were...
Gradual loss of terminal differentiation markers and gain stem cell-like properties is a major hall mark cancer malignant progression. The cell pluripotent transcriptional factor SOX family play critical roles in governing tumor plasticity lineage specification. This study aims to establish novel signature monitor the extent dedifferentiation predict prognostic significance hepatocellular carcinoma (HCC).The RNA-seq data from Cancer Genome Atlas (TCGA) LIHC project were chronologically...
Malignant ascites, a complication often seen in patients with ovarian cancer (OC), is difficult to treat, but hyperthermic intraperitoneal chemotherapy (HIPEC) has good efficacy.The aim of this study was assess the efficacy cytoreductive surgery (CRS) combined HIPEC for controlling malignant ascites from OC.From December 2009 until 2014, 53 OC and were treated CRS HIPEC. Patients health condition followed by (CRS + HIPEC), poor initially B-mode ultrasound-guided delayed upon improvement...