A5105464837- Cancer-related gene regulation
- Renal Diseases and Glomerulopathies
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Ultrasound and Hyperthermia Applications
- TGF-β signaling in diseases
- RNA modifications and cancer
- Renal Transplantation Outcomes and Treatments
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Genetic factors in colorectal cancer
- Protease and Inhibitor Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Blood Coagulation and Thrombosis Mechanisms
- Ubiquitin and proteasome pathways
Chinese University of Hong Kong
2007-2025
University of Hong Kong
2013-2025
Queen Mary Hospital
2008-2021
City University of Hong Kong, Shenzhen Research Institute
2015-2018
HKU-Pasteur Research Pole
2016
Griffith University
2015
Jinan University
2014
First Affiliated Hospital of Zhengzhou University
2012-2013
Zhengzhou University
2013
Sun Yat-sen University
2013
The combination of cyclophosphamide and prednisolone is effective for the treatment severe lupus nephritis but has serious adverse effects. Whether mycophenolate mofetil can be substituted not known.
Androgen-independent metastatic prostate cancer is the main obstacle in treatment of this cancer. Unlike a majority solid cancers, usually shows poor response to chemotherapeutic drugs. In study, we have shown potential novel target, TWIST, highly conserved bHLH transcription factor, Using malignant and nonmalignant tissues, found that TWIST expression was expressed (90%) tissues but only small percentage (6.7%) benign hyperplasia. addition, levels were positively correlated with Gleason...
Abstract Recent efforts in our study of cancer stem cells (CSC) hepatocellular carcinoma (HCC) have led to the identification CD133 as a prominent HCC CSC marker. Findings were based on experiments done cell lines and xenograft tumors where expression was detected at levels high 65%. Based theory, CSCs are believed represent only minority number tumor mass. This is indicative that previously characterized CD133+ population still heterogeneous, consisting perhaps subsets with differing...
Inflammation contributes to the tubulointerstitial lesions of diabetic nephropathy. Toll-like receptors (TLRs) modulate immune responses and inflammatory diseases, but their role in nephropathy is not well understood. In this study, we found increased expression TLR4 TLR2 renal tubules human kidneys with compared normal kidney disease from other causes. The intensity tubular correlated directly interstitial macrophage infiltration hemoglobin A1c level inversely estimated glomerular...
A novel theory in the field of tumor biology postulates that cancer growth is driven by a population stem-like cells, called tumor-initiating cells (TICs). We previously identified TIC derived from hepatocellular carcinoma (HCC) characterized membrane expression CD133. Here, we describe mechanism which these mediate and angiogenesis systematic comparison gene profiles between sorted CD133 liver subpopulations through genome-wide microarray analysis. significantly dysregulated interleukin-8...
Wnt/β‐catenin signaling is activated in CD133 liver cancer stem cells (CSCs), a subset of known to be root tumor recurrence and therapy resistance hepatocellular carcinoma (HCC). However, the regulatory mechanism this pathway CSCs remains unclear. Here, we show that human microRNA (miRNA), miR‐1246, promotes stemness, including self‐renewal, drug resistance, tumorigencity, metastasis, by activation through suppressing expression AXIN2 glycogen synthase kinase 3β (GSK3β), two key members...
Renal tubulointerstitial injury is characterized by inflammatory cell infiltrate; however, the stimuli for leukocyte recruitment are not fully understood. IL-8 a potent chemokine produced proximal tubular epithelial cells (PTECs). Whether nephrotic proteins stimulate expression remains unknown. Acute exposure of human PTECs to albumin induced gene and protein time- dose-dependently. Apical predominantly stimulated basolateral secretion. Electrophoretic mobility shift assay demonstrated...
A colonoscopy survey of 620 patients with 1049 colon adenomas showed a predominantly left-sided distribution (77%). Of these lesions 97% were amenable to endoscopic removal or ablation. Sixty per cent presented rectal bleeding as their major symptom. There was agreement between radiology and in only 62% patients, many the studies single contrast barium enemas, performed before referral. Forty-eight our series less than 1.0 cm diameter. larger (greater 2.0 diameter) 66% situated sigmoid...
Abstract Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely a specific subpopulation of needed for initiation and progression. TICs have yet to be identified in esophageal tumors that an increasing incidence developed countries. Here, we report CD90+ cell population found squamous carcinoma (ESCC), which is endowed with cell–like properties high tumorigenic metastatic potential. mRNA profiling these suggested pathways through they drive tumor growth...
Esophageal cancer is one of the most lethal cancers worldwide with poor survival and limited therapeutic options. The discovery microRNAs created a new milestone in research. miR-377 located chromosome region 14q32, which frequently deleted esophageal squamous cell carcinoma (ESCC), but biological functions, clinical significance implication ESCC are largely unknown. In this study, we found that expression was significantly downregulated tumor tissue serum patients ESCC. Both levels were...
Esophageal squamous cell carcinoma (ESCC), the major histologic subtype of esophageal cancer, is a devastating disease characterized by distinctly high incidences and mortality rates. However, there remains limited understanding molecular events leading to development progression disease, which are paramount importance defining biomarkers for diagnosis, prognosis, personalized treatment. By high-throughout transcriptome sequence profiling nontumor ESCC clinical samples, we identified subset...
Abstract Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG between tumour and corresponding non-tumour tissues oesophageal squamous cell carcinoma (OSCC), we find that Integrin α7 ( ITGA7 ) is characterized as a potential cancer (CSC) marker. Clinical data show high frequency of + cells OSCC significantly poor differentiation, lymph node metastasis worse prognosis. Functional studies...
The current study reveals the clinicopathological association of PD-L1 in Hong Kong esophageal squamous cell carcinoma (ESCC) patients and differential regulation by standard first-line chemotherapy ESCC. Immunohistochemical analysis tissue microarray data from 84 ESCC shows that was expressed 21% tumors. Positive staining significantly associated with later disease stage (stages III IV) (P value = .0379) lymph node metastasis .0466) cohort. Furthermore, expression induced lines after...
Objective To analyze the clinicopathologic features of a large cohort patients with insular or anaplastic carcinomas treated at single institution. Summary Background Data Insular and thyroid, although uncommon, have more aggressive clinical behavior than well-differentiated thyroid. In literature, incidence these not been fully characterized. Methods The authors reclassified 740 primary thyroid diagnosed between January 1, 1954, December 30, 1998, to select those that met histologic...
To study the outcome and prognostic indicators of diffuse proliferative glomerulonephritis (DPGN) in patients with systemic lupus erythematosus (SLE) treated sequential oral cyclophosphamide (CYC) azathioprine (AZA).SLE biopsy-proven DPGN CYC AZA were studied. Those who achieved renal remission at 12 months identified, clinical predictors complete evaluated by regression analysis. All followed up until a relapse nephritis or doubling serum creatinine level occurred. The timing risk factors...
ADAMTS metalloprotease family member ADAMTS9 maps to 3p14.2 and shows significant associations with the aerodigestive tract cancers esophageal squamous cell carcinoma (ESCC) nasopharyngeal (NPC). However, functional impact of on cancer development has not been explored. In this study, we evaluated hypothesized antiangiogenic tumor-suppressive functions in ESCC NPC, stringent tumorigenicity Matrigel plug angiogenesis assays. activation suppressed tumor formation nude mice. Conversely,...
Abstract Local interactions between cancer cells and stroma can produce systemic effects on distant organs to govern progression. Here we show that IGF2 secreted by inhibitor of differentiation (Id1)-overexpressing oesophageal instigates VEGFR1-positive bone marrow in the tumour macroenvironment form pre-metastatic niches at sites increasing VEGF secretion from cancer-associated fibroblasts. Cancer are then attracted metastatic site via CXCL5/CXCR2 axis. Bone transplanted nude mice bearing...
Abstract Expression of microRNA genes is profoundly altered in cancer but their role the development androgen-independent prostate has received limited attention as yet. In this study, we report a functional impact cells for overexpression miR-616, which occurred consistently that were (AI) versus androgen-dependent (AD). miR-616 was confirmed malignant tissues opposed to benign specimens. Stable LNCaP by lentiviral-based approach stimulated AI cell proliferation vitro whereas concomitantly...
Frequent tumor relapse in hepatocellular carcinoma (HCC) has been commonly attributed to the presence of residual cancer stem cells (CSCs) after conventional treatments. We have previously identified and characterized CD133 mark a specific CSC subset HCC. In present study, we found endogenous secretory annexin A3 (ANXA3) play pivotal roles promoting cell-like features CD133+ liver CSCs through dysregulated JNK pathway. Blockade ANXA3 with an anti-ANXA3 monoclonal antibody vitro as well human...
Abstract Suppressive effects of DUSP6 in tumorigenesis and EMT‐associated properties were observed. Dual‐specificity phosphatase (DUSP6) is a MAP kinase (MKP) negatively regulating the activity ERK, one major molecular switches MAPK signaling cascade propagating responses during malignancies. The impact EMT its contribution to tumor dissemination has not yet been characterized. Due differences microenvironments affecting cell cancer progression, may play varying roles development. We sought...