A5043751229- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Antibiotic Resistance in Bacteria
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Circular RNAs in diseases
- Syphilis Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- T-cell and Retrovirus Studies
- Vibrio bacteria research studies
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- Liver physiology and pathology
- Mesenchymal stem cell research
- Pneumonia and Respiratory Infections
- Nanoplatforms for cancer theranostics
- Cutaneous lymphoproliferative disorders research
- Cancer Immunotherapy and Biomarkers
- Reproductive System and Pregnancy
- Pancreatic function and diabetes
Fox Chase Cancer Center
2019-2023
Harvard Stem Cell Institute
2022
Harvard University
2015-2022
Soochow University
2021
China Medical University
2010-2020
Shandong Provincial Hospital
2020
Anhui Medical University
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Sun Yat-sen University Cancer Center
2013-2019
First Hospital of China Medical University
2009-2019
Macrophages (Mphi) are prominent components of solid tumors and exhibit distinct phenotypes in different microenvironments. We have recently found that can alter the normal developmental process Mphi to trigger transient activation monocytes peritumoral stroma. showed a fraction monocytes/Mphi stroma, but not cancer nests, expresses surface PD-L1 (also termed B7-H1) molecules from patients with hepatocellular carcinoma (HCC). Monocytes activated by strongly express proteins kinetics similar...
Hepatocellular carcinoma (HCC) is a highly vascularized tumor with frequent intrahepatic metastasis. Active angiogenesis and metastasis are responsible for rapid recurrence poor survival of HCC. We previously found that microRNA-29b (miR-29b) down-regulation was significantly associated recurrence-free HCC patients. Therefore, the role miR-29b in angiogenesis, invasion, further investigated this study using vitro capillary tube formation transwell assays, vivo subcutaneous orthotopic...
Abstract Epstein–Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection epithelial cells remain elusive. glycoprotein (gB) the critical fusion protein for both cells, determines susceptibility non-B cells. Here we show that neuropilin 1 (NRP1) directly interacts with gB 23–431 . Either knockdown NRP1 or pretreatment soluble suppresses infection. Upregulation by overexpression EGF treatment enhances...
Tim-3, a member of the novel Tim (T cell immunoglobulin and mucin domain) family, has been reported to negatively regulate immune responses against viral infection had implications for autoimmune disease. However, nature role Tim-3+ CD4 T cells in human tumors remain largely unknown. In present study, we characterized 100 specimens from hepatocellular, cervical, colorectal ovarian carcinoma patients. Compared with peripheral blood nontumor-infiltrating lymphocytes, lymphocytes isolated...
Background and aims Hepatocyte nuclear factor 4α (HNF4α) is a central transcriptional regulator of hepatocyte differentiation function. The aim this study was to evaluate the effect HNF4α on attenuation hepatic fibrosis. Methods adenoviruses carrying gene or containing siRNA targeting were injected through tail vein two distinct fibrosis models either induced by dimethylnitrosamine bile duct ligation in rats. Moreover, HNF4α, epithelial–mesenchymal transition (EMT)-related fibrotic markers...
Although the alterations of lipid profile in lung cancer have been documented, prognostic value serum HDL-C level and its correlation with inflammation NSCLC remain unknown.Levels preoperative concentrations (including HDL-C, LDL-C, TC, TG) inflammatory biomarker C-reactive protein (CRP) were retrospectively analyzed 228 patients 300 healthy controls. The levels these two populations compared. Univariate multivariate cox hazards analyses performed to investigate NSCLC. between CRP also...
Background: Many studies have shown the prognostic value of inflammation based factors in different cancers.This work aimed to explore pretreatment C-reactive protein/albumin (CRP/Alb) ratio patients with cervical cancer, and compared other inflammatory factors, such as neutrophil/lymphocyte ratio(NLR), Glasgow score (mGPS), index (PI), platelet/lymphocyte (PLR), nutritional (PNI), clinicopathological parameter squamous cell carcinoma antigen (SCC-Ag).Methods: This study was a retrospective...
Transcription factor Sp1 is multifaceted, with the ability to function as an oncogene or a tumor suppressor, depending on cellular context. We previously reported that required for transcriptional activation of key oncogenes in nasopharyngeal carcinoma (NPC), including B-lymphoma mouse Moloney leukemia virus insertion region 1 (Bmi1) and centromere protein H (CENPH), but role its underlying mechanisms NPC remained largely unexplored. The objective this study was investigate verify clinical...
T cell suppression in sepsis is a well-known phenomenon; however, the underlying mechanisms are not fully understood. Previous studies have shown that stimulation up-regulates mitochondrial adenosine triphosphate (ATP) production to fuel purinergic signaling necessary for adequate responses. Here we show basal ATP production, release, and of P2X1 receptors represent standby mechanism antigen recognition. Inhibition this process impairs vigilance ability cells trigger activation, up-regulate...
Sepsis remains an unresolved clinical problem. Therapeutic strategies focusing on inhibition of neutrophils (polymorphonuclear neutrophils) have failed, which indicates that a more detailed understanding the underlying pathophysiology sepsis is required. Polymorphonuclear neutrophil activation and chemotaxis require cellular adenosine triphosphate release via pannexin-1 channels fuel autocrine feedback purinergic receptors. In current study, we examined roles endogenous systemic...
Abstract Wound healing is a high energy demanding process that needs good coordination of the mitochondria with glycolysis in characteristic highly hypoxic environment. In diabetes, hyperglycemia impairs adaptive responses to hypoxia profound negative effects on different cellular compartments wound healing. miR-210 hypoxia-induced microRNA regulates metabolism and processes important for Here, we show blunted hypoxia-dependent induction both vitro human mouse diabetic wounds. The impaired...
Damage in COVID-19 results from both the SARS-CoV-2 virus and its triggered overactive host immune responses. Therapeutic agents that focus solely on reducing viral load or hyperinflammation fail to provide satisfying outcomes all cases. Although cellular factors have been extensively profiled identify potential anti-COVID-19 targets, new drugs with significant efficacy remain be developed. Here, we report potent preclinical of ALD-R491, a vimentin-targeting small molecule compound, treating...
Hemostatic alterations occur during the development of cancer. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker that increased in patients with various solid tumours. The aim this study was to evaluate hemostatic status nasopharyngeal carcinoma (NPC) by assessing plasma levels investigate its value as prognostic marker.We retrospectively analysed 717 carcinoma, we applied Cox regression log-rank tests assess association disease-free survival (DFS), distant...
Preoperative serum lactate dehydrogenase (LDH) has been used as a prognostic indicator for patients with hepatocellular carcinoma (HCC) treated sorafenib or undergoing transcatheter arterial chemoembolization, but its significance in predicting survival of HCC who received curative resection remains undefined. A total 683 histopathologically confirmed were enrolled this study. The preoperative LDH was determined by Kaplan-Meier analysis and Cox proportional hazards regression model....
Prunella vulgaris L. (P. vulgaris) has traditionally been used to treat swelling and inflammation of the thyroid gland. This study aimed evaluate effects P. on experimental autoimmune thyroiditis (EAT) explore roles indoleamine 2,3-dioxygenase 1 (IDO1) regulatory T cells (Tregs) in these vulgaris-mediated effects. The main bioactive compounds were analysed by high-performance liquid chromatography. An EAT model was established immunization Lewis rats with thyroglobulin via subcutaneous...