A5101771419- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Circular RNAs in diseases
- Gut microbiota and health
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Gastrointestinal motility and disorders
- Pancreatic and Hepatic Oncology Research
- Ultrasound Imaging and Elastography
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Hepatitis C virus research
- Probiotics and Fermented Foods
- Travel-related health issues
- Pancreatitis Pathology and Treatment
- Liver Diseases and Immunity
- Gastroesophageal reflux and treatments
- Metastasis and carcinoma case studies
- Aldose Reductase and Taurine
- Nutrition and Health in Aging
- Pancreatic function and diabetes
- Heparin-Induced Thrombocytopenia and Thrombosis
Fujian Medical University
2012-2025
Shanghai Changzheng Hospital
2014-2025
Union Hospital
2025
Fujian Provincial Hospital
2024
Fuzhou University
2024
Yancheng Teachers University
2024
Institute of Geographic Sciences and Natural Resources Research
2022
Chinese Academy of Sciences
2022
University of Chinese Academy of Sciences
2022
Zhangzhou Municipal Hospital of Fujian Province
2021
Background and aims Hepatocyte nuclear factor 4α (HNF4α) is a central transcriptional regulator of hepatocyte differentiation function. The aim this study was to evaluate the effect HNF4α on attenuation hepatic fibrosis. Methods adenoviruses carrying gene or containing siRNA targeting were injected through tail vein two distinct fibrosis models either induced by dimethylnitrosamine bile duct ligation in rats. Moreover, HNF4α, epithelial–mesenchymal transition (EMT)-related fibrotic markers...
Background MicroRNA-21 (miR-21) plays an important role in the pathogenesis and progression of liver fibrosis. Here, we determined serum hepatic content miR-21 patients with cirrhosis rats dimethylnitrosamine-induced examined effects on SPRY2 HNF4α modulating ERK1 signaling stellate cells (HSCs) epithelial-mesenchymal transition (EMT) hepatocytes. Methods Quantitative RT-PCR was used to determine expression SPRY2, other genes. Immunoblotting assay carried out examine relevant proteins....
Sulforaphane is a common antioxidant selectively abundant in cruciferous plants, which exhibits effective anti-cancer actions control of tumorigenesis or progression various cancers. A recent study has shown that sulforaphane attenuates the EGFR signaling pathway non-small cell lung cancer (NSCLC), suggesting its potential anti-metastatic effects. In this we assessed involvement and miR-616-5p epithelial-mesenchymal transition (EMT) NSCLC metastasis. suppressed proliferation human lines...
This study aimed to investigate whether driving pressure-guided ventilation can reduce postoperative pulmonary complications in patients who have undergone heart transplantation. Patients underwent orthotopic transplantation were divided into two groups according the perioperative strategy: (1) conventional lung-protective (group C) and (2) D). The primary outcome was occurrence of within 30 days surgery. Univariate multivariate logistic regression analyses performed evaluate independent...
Background Liver cirrhosis seriously harms human health and fibrosis is the essential pathological process of cirrhosis. Recently, circular RNAs (circRNAs) were found to play critical roles in liver fibrosis, but key circRNAs precise mechanisms remained unclear. This study aimed investigate effect circ_0098181 fibrogenesis explore its mechanism. Methods RNA sequencing was conducted identify circRNA signatures cirrhotic tissues. Hepatic stellate cells (HSCs) (including primary rat HSCs, LX2,...
Aims: The effect of ursodeoxycholic acid (UDCA) treatment on survival and liver histological progression primary sclerosing cholangitis (PSC) remains uncertain. aim the present study was to evaluate safety UDCA in PSC. Methods: Electronic databases including Medline, Embase, Cochrane controlled trials register, Web Science PubMed (updated January 2009) manual bibliographical searches were carried out. A meta‐analysis all randomized (RCT) comparing with placebo or no Results: Eight RCT 465...
Abstract Background & Aims Epithelial‐mesenchymal transition ( EMT ) process and extracellular signal‐regulated kinase 1 ERK 1) signalling pathway play pivotal roles in hepatic stellate cell HSC activation, which is associated with the altered expression patterns of micro RNA s (mi s). miR‐155 considered a typical multifunctional mi to regulate many biological processes. However, little attention has been given contributions simultaneous regulation during activation. Methods Differential...
MicroRNA-21 (miR-21) has emerged as a critical regulatory molecule and an important serum marker in hepatic fibrogenesis. The aim of the present study was to investigate role inhibiting miR-21 on fibrosis treatment. Serum levels 60 healthy individuals 180 patients with different stages liver cirrhosis were examined, normal or cirrhotic human tissues (n=10 each) also detected. An adenoviral vector (Ad-TuD-21) carrying sponging ToughDecoy (TuD)-RNA sequence against constructed reduce...
Abstract Extracellular signal-regulated kinase 1 (ERK1) is a critical part of the mitogen-activated protein signal transduction pathway, which involved in hepatic fibrosis. However, effect down-regulation ERK1 on fibrosis has not been reported. Here, we induced rats with dimethylnitrosamine administration or bile duct ligation. An adenovirus carrying small interfering RNA targeting (AdshERK1) was constructed to determine its fibrosis, as evaluated by histological and immunohistochemical...
Abstract Studies have demonstrated that comorbidities, especially cardiovascular and endocrine diseases, correlated with poorer clinical outcomes. However, the impact of digestive system diseases has not been issued. The aim this study is to determine laryngopharyngeal reflux disease (LPRD) on hospitalized patients coronavirus 2019 (COVID‐19). We extracted data regarding 95 in Wuhan Jinyintan Hospital, Wuhan, China, between 26 January 21 February 2020. Reflux Symptom Index (RSI) was used...
Abstract Differentiation of stem cells is tightly regulated by the microenvironment which mainly composed nonparenchymal cells. Herein, we investigated effect hepatic stellate (HSCs) in different states on mesenchymal (MSCs) differentiation. Rat HSCs were isolated and stayed quiescent within 5 days. Primary activated being vitro cultured for 7 days or cocultured with Kupffer MSCs states. Expression lineage markers was analyzed RT‐PCR immunofluorescence. Glycogen deposition detected periodic...
After decades of increase, lung cancer has become the leading cause death among women. The mortality rate from is ascending at a relatively steady rate, which greatly affected health female population and serious issue. A case-control study 226 cases 269 controls was conducted 2006 to 2010 in Fujian Province. structured questionnaire used gather information on demographic characteristics as well dietary environmental factors. Odds ratios 95% confidence intervals were estimated by using...
The general transcription factor IIF (TFIIF) assembled in the initiation complex, and RAP30 of TFIIF, have been shown to associate with RNA polymerase II (pol II), although it remains unclear which pol subunit is responsible for interaction. We examined whether TFIIF interacts 5 (RPB5), exposed domain binds transcriptional regulatory factors such as hepatitis B virus X protein a novel protein, RPB5-mediating protein. results demonstrated that RPB5 directly vitro using purified recombinant...
The hepatitis C virus (HCV) nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRP), a central catalytic enzyme for HCV replication. To further understand the structure and functions of NS5B, we introduced series 27 clustered 19 point substitution mutations within outside well-known motifs conserved among RdRP by alanine scanning investigated effects these mutants on enzymatic activity NS5B. Surprisingly, most (22 mutants) do not affect at all, indicating that side chains...
Abstract: Purpose: To investigate the effect of combinational delivery urokinase‐type plasminogen activator (uPA) and hepatocyte growth factor (HGF) genes on hepatic fibrosis. Methods: Replication‐deficient adenoviral vectors expressing either human HGF (AdHGF) or uPA (AduPA) were generated. gene was transferred into primary cultured hepatocytes to stellate cell (HSC) biological character cells. Combinational adenoviruses infused fibrosis rats. Serum markers as well histological...