A5103007271- Chronic Lymphocytic Leukemia Research
- Thyroid Disorders and Treatments
- Phagocytosis and Immune Regulation
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Dermatology and Skin Diseases
- Atherosclerosis and Cardiovascular Diseases
- Peptidase Inhibition and Analysis
- Thyroid Cancer Diagnosis and Treatment
- Immune cells in cancer
- Mass Spectrometry Techniques and Applications
- Liver physiology and pathology
- Corporate Finance and Governance
- Dermatological diseases and infestations
- Cell death mechanisms and regulation
- Medicinal plant effects and applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Research on Leishmaniasis Studies
- Contact Dermatitis and Allergies
- Tuberculosis Research and Epidemiology
- Receptor Mechanisms and Signaling
- Skin Protection and Aging
- Parathyroid Disorders and Treatments
- Calcium signaling and nucleotide metabolism
- Psoriasis: Treatment and Pathogenesis
Xiamen University
2005-2024
Children's Hospital of Zhejiang University
2024
Jiangsu University
2024
Wuhan No.1 Hospital
2020-2023
The University of Texas MD Anderson Cancer Center
2020-2022
University College London
2021
Xiamen Medical College
2019-2020
Fudan University
2019
Eye & ENT Hospital of Fudan University
2019
Obstetrics and Gynecology Hospital of Fudan University
2017
Dermatitis is an important global health problem that not only affects social interaction and physical mental but also causes economic burden. Health problems or distress caused by dermatitis may be easily overlooked, relevant epidemiological data are limited. Therefore, a better understanding of the burden necessary for developing intervention strategies.All on dermatitis, including atopic (AD), contact (CD) seborrhoeic (SD), were obtained from Global Burden Disease 2019 (GBD2019) database....
Abstract Purpose: Survival of CLL cells due to the presence Bcl-2 and Mcl-1 has been established. Direct inhibition by venetoclax indirect targeting with transcription inhibitors have successful approaches for CLL. AMG-176 is a selective direct antagonist Mcl-1, which shown efficacy in several hematologic malignancies; however, its effect on elusive. We evaluated biological molecular effects primary cells. Experimental Design: Using samples from patients (n = 74) CLL, we tested normal...
Background: NLRP3 inflammasome is an inflammatory mediator. The expression of associated with the development various tumors and closely related to prognosis tumors. However, role in laryngeal squamous cell carcinoma (LSCC) remains unclear. This study aim investigate influence NLPR3 LSCC, especially level LSCC after surgery a Chinese population. Methods: We used quantitative real-time PCR immunohistochemical (IHC) staining calculate mRNA (20 patients, fresh tissue) protein (104 paraffin...
Background Tuberculosis (TB) always runs in the forefront of global burden when it comes to infectious diseases. Tuberculosis, which can lead impairment quality life, financial hardship, discrimination, marginalization, and social barriers, is a major public health problem. The assessment TB trend provide crucial information for policy decision planning, help countries world achieve goal sustainable development ending epidemic 2030. Methods All data are from Global Burden Disease 2019 (GBD...
Abstract Studies have demonstrated that comorbidities, especially cardiovascular and endocrine diseases, correlated with poorer clinical outcomes. However, the impact of digestive system diseases has not been issued. The aim this study is to determine laryngopharyngeal reflux disease (LPRD) on hospitalized patients coronavirus 2019 (COVID‐19). We extracted data regarding 95 in Wuhan Jinyintan Hospital, Wuhan, China, between 26 January 21 February 2020. Reflux Symptom Index (RSI) was used...
B-cell receptor (BCR) signaling pathway and Bcl-2 family prosurvival proteins, specifically Mcl-1, are functional in the pathobiology of chronic lymphocytic leukemia (CLL). A pivotal apical molecule BCR is Bruton's tyrosine kinase (BTK). Together, BTK, Bcl-2, Mcl-1 participate maintenance, migration, proliferation, survival CLL cells. Several ongoing published clinical trials reported high rates remission, namely, undetectable measurable residual disease (u-MRD) status with combined BTK...
It was the aim of present study to characterize modulatory effect muscarinic agonists on overflow norepinephrine and neuropeptide Y (NPY) from in situ perfused guinea pig heart, induced by electrical stimulation left stellate ganglion (6 Hz, 5 V, 1 min). The oxotremorine (0.01-1 microM) carbachol (0.1-10 reduced NPY a concentration-dependent manner approximately 30% control. inhibitory antagonized unspecific antagonist atropine (1 but not nicotinic hexamethonium (100 microM). M2-specific...
Using immunoelectron microscopy and a color image analyzer, we quantified the kinetics of synthesis, secretion reabsorption thyroglobulin (Tg) in rat thyroid follicular epithelium under thyrotropin (TSH) stimulation. Seven week-old male Wistar rats were injected intravenously with 2IU TSH. Thyroid glands removed at 5, 30min, 1 3 hr after injection, fixed immediately 1% glutaraldehyde 4% paraformaldehyde, post-fixed osmium tetroxide embedded LR-White. Immunostaining was performed anti-rat Tg...
This study aimed to investigate the association between central sensitivity thyroid hormones and all-cause mortality in euthyroid patients with chronic kidney disease (CKD). Data on function indicators for CKD were extracted from NHANES database (2007–2012). Central sensitivities mainly evaluated by Thyroid Feedback Quantile-based Index (TFQI). The Kaplan–Meier method, Cox proportional hazards regression model subgroup analysis performed explore potential associations hormone mortality. A...
Objective: The present study aimed to explore the correlation of protein kinase D 1 with prognosis in bortezomib-treated multiple myeloma patients and further investigate effect knockdown on drug sensitivity bortezomib cells. Methods: Totally, 104 de novo symptomatic treated bortezomib-based regimens 30 healthy controls were recruited. Bone marrow mononuclear cells–derived plasma cells collected from before initial treatment bone donation, respectively, then protein/messenger RNA expressions...
Objective: To investigate the clinical and biological characteristics of familial platelet disorder (FPD) with germline Runt-related transcription factor (RUNX) 1 mutations. Methods: Patients diagnosed myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) RUNX1 mutations from February 2016 to December 2021 in Wuhan No.1 Hospital underwent pedigree analysis were screened for gene (somatic germline). FPD enrolled evaluated terms evolution. Bioinformatics was used assess pathogenicity...
目的 探讨继发性白血病（SL）患者的临床特点、治疗及预后。 方法 回顾性分析2012年1月至2016年12月武汉市第一医院诊治的15例初诊SL患者的临床特点、染色体核型及分子学突变、治疗经过及转归。 结果 15例SL患者中，男性9例，女性6例，中位年龄62岁（40~77岁）；急性淋巴细胞白血病（ALL）1例，急性非淋巴细胞白血病14例（包括急性早幼粒细胞白血病1例）；10例患者至少检测到1种预后相关基因突变，检出率较高的基因突变为FLT3-ITD 5例，DNMT3A...
Background: Dermatitis is an important global health problem that not only affects social interaction and physical mental but also causes economic burden. Health problems or distress caused by dermatitis may be easily overlooked, relevant epidemiological data are limited. Therefore, a better understanding of the burden necessary for developing intervention strategies.Methods: All on dermatitis, including atopic dermatitis(AD), contact dermatitis(CD) seborrhoeic dermatitis(SD), were obtained...
Abstract Background Traditional eating habits in Eastern Europe are associated with higher risk of all-cause and cardiovascular disease mortality. However, it is unclear whether this pattern related to socio-economic characteristics individuals. The aim analysis was examine the socioeconomic determinants traditional diet European populations. Methods Data available from baseline survey Health, Alcohol Psychosocial Factors study, including 21,752 eligible subjects Russia, Poland Czech...