A5100731568- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal and GI Pathology
- Hepatitis Viruses Studies and Epidemiology
- Gastroesophageal reflux and treatments
- Allergic Rhinitis and Sensitization
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Innovations in Medical Education
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Medical Research and Treatments
- Lung Cancer Treatments and Mutations
- Platelet Disorders and Treatments
- Vascular Anomalies and Treatments
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Asthma and respiratory diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lung Cancer Research Studies
Shandong Provincial Hospital
2016-2025
Shandong University
2016-2025
Shandong First Medical University
2020-2025
Army Medical University
2022-2024
Xinqiao Hospital
2023-2024
Creative Commons
2022
Qilu Hospital of Shandong University
2003-2022
Shandong Center for Disease Control and Prevention
2017-2018
Shenyang Center for Disease Control and Prevention
2017
Qiqihar Medical University
2017
Objectives Early placement of transjugular intrahepatic portosystemic shunt (TIPS) has been shown to improve survival in high-risk patients (Child-Pugh B plus active bleeding at endoscopy or Child-Pugh C 10–13) with cirrhosis and acute variceal (AVB). However, early TIPS criteria may overestimate the mortality risk a significant proportion patients, benefit conferred by such questioned. Alternative have proposed refine used identify candidates for TIPS. Nevertheless, true provided (or not)...
Extracellular adenosine triphosphate (ATP) functions as a novel danger signal that boosts antitumor immunity and can also directly kill tumor cells. We have previously reported chronic exposure of cells to ATP provokes P2X7-mediated cell death, by yet incompletely defined molecular mechanisms.Here, we show acute results in rapid cytotoxic effects impacting several aspects growth/survival, leading inhibition growth vitro vivo. Using agonist antagonist studies together with generation P2X7...
Carvedilol has been identified as a promising agent for the treatment of liver fibrosis. Meanwhile, autophagy and apoptosis have reported to play key roles in activation hepatic stellate cells (HSCs), which can contribute progression However, effects carvedilol on HSCs remain unclear. Our study aimed detect these identify underlying mechanisms by mediates HSC apoptosis. For this purpose, LX-2 cell line was used study, were exposed various concentrations specific times. First, we found that...
Abstract: The treatment of chronic idiopathic thrombocytopenic purpura (ITP) is difficult in those unresponsive to corticosteroids and/or splenectomy. We attempted induce durable response 21 patients with refractory ITP by applying mycophenolate mofetil (MMF) (1.5–2.0 g/d), a novel immunosuppressive agent. Overall rate was 62% (13 21), including 24% (five 21) complete (CR), 29% (six partial (PR), and 10% (two minor (MR). rates for non‐splenectomized splenectomized were 64% (nine 14) 57%...
To report the long-term effect of stent placement in 115 patients with Budd-Chiari syndrome (BCS).One hundred and fifteen BCS were treated by percutaneous placement. One two had IVC placement, 30 HV 17 them underwent both stent. All procedures performed guidance ultrasound.The successful rates placing 94% (96/102) 87% (26/30), respectively. Ninety-seven 112 stents (90 stents, 22 stents) followed up. 96.7% (87/90) 90.9% (20/22) remained patent during follow up periods (mean 49 months, 45...
Summary We investigated a genetic pathway in root hair development Arabidopsis thaliana , involving the receptor‐like kinase FERONIA ( FER ), two guanine nucleotide exchange factors for ROP s (Rop GEF 4 and Rop 10), small GTP ase Rho of plants s). Loss‐ gain‐of‐function analyses demonstrated distinct roles 10 such that is only important elongation, while mainly contributes to initiation. Domain dissection by truncation domain‐swapping experiments indicated their functional distinctions were...
To investigate the effect of carvedilol on liver fibrosis and hepatic sinusoidal capillarization in mice with carbon tetrachloride (CCl4)-induced fibrosis.A mouse model was induced by intraperitoneal CCl4 injection for 8 weeks. The were divided into five experimental groups: normal group, oil CCl4+carvedilol (5 mg/kg/d) (10 group. extent evaluated histopathological staining, changes fenestrations sinus endothelial cells observed scanning electron microscope (SEM). expression α-smooth muscle...
To investigate the effect of doxazosin on autophagy and activation hepatic stellate cells (HSCs) in vivo vitro determine underlying mechanism.In vivo, a mouse liver fibrosis model was induced by intraperitoneal injection carbon tetrachloride (CCl4). Doxazosin administered at doses 2.5, 5 10 mg/(kg*day) gavage. After 20 weeks, blood tissues were collected for serological histological analysis, respectively. Blood hematoxylin eosin (HE) staining, Masson's trichrome immunohistochemistry...
Gastric cancer is the second leading cause of cancer-associated mortality and a frequently occurring worldwide. Multiple drug resistance gastric cells leads to poor prognosis. In addition, overexpression anti-apoptotic protein B-cell lymphoma (Bcl)-2 have been demonstrated in various closely associated with Naringenin flavonoid that has antimutagenic anticarcinogenic activities numerous types. present study, naringenin Bcl-2 inhibitor, ABT-737, were used investigate their combinative...
A 53-year-old man with a 10-year history of cirrhosis was admitted for evaluation following eight episodes hepatic encephalopathy in the past 6 months. Enhanced computed tomography (CT) revealed portal vein stenosis and splenorenal shunt (Figure 1A,B). The patient's Child–Pugh score 9, his blood ammonia level 57 μmol/L. Coil embolisation performed upon admission 2). Postoperatively, patient developed severe abdominal pain bloody ascites, likely due to acute pressure elevation (portal not...
Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for managing portal hypertension in cirrhotic patients, but the impact of post-TIPS overt hepatic encephalopathy (OHE) on survival remains controversial. While its effect short-term well-documented, long-term implications remain unclear. This study aims to investigate OHE mortality patients variceal bleeding, focusing timing and predictive value beyond first year post-TIPS. A multicenter, retrospective cohort...
Patients with recurrent or refractory ascites can benefit from transjugular intrahepatic portosystemic shunt (TIPS). However, the value of TIPS for patients large remains unclear. This retrospective multicenter study included who underwent medicine plus large-volume paracentesis (medicine + LVP) between January 2014 and December 2022 at five centers. The primary endpoint was recurrence worsening ascites. secondary endpoints were liver-related death, all-cause hemorrhage, overt hepatic...
Recent data suggest that noninvasive liver fibrosis indexes could be useful for predicting esophageal varices (EV) in cirrhotic patients. However, thus far, the diagnostic efficacy of these portal hypertension (PH) patients has been poorly evaluated.To evaluate diagnosis PH.A total 238 underwent hepatic venous pressure gradient (HVPG) evaluation and relevant serum tests to analyze variables associated with PH grade. Then, performances seven indexes, aspartate aminotransferase...
To investigate the effect of metformin on activated hepatic stellate cells (HSCs) and possible signaling pathways involved.A fibrotic mouse model was generated by intraperitoneal injection carbon tetrachloride (CCl4) subsequent treatment with or without metformin. The level fibrosis detected hematoxylin-eosin staining, Sirius Red immunohistochemistry. HSC cell line LX-2 used for in vitro studies. proliferation (CCK8 assay), motility (scratch test Transwell contraction (collagen gel...
Background and Aims Optimal candidates for early transjugular intrahepatic portosystemic shunt (TIPS) in patients with Child‐Pugh B cirrhosis acute variceal bleeding (AVB) remain unclear. This study aimed to test the hypothesis that risk stratification using Chronic Liver Failure Consortium Acute Decompensation score (CLIF‐C ADs) may be useful identify a subgroup at high of mortality or further benefit from TIPS AVB. Approach Results We analyzed pooled individual data two previous studies...
Abstract Long noncoding RNA (lncRNA) LINC‐PINT expression is inhibited in many types of cancer cells, suggesting its role as a tumor suppressor. However, the functionality gastric and clinical values are unknown. In present study, we found that lncRNA was downregulated, while microRNA‐21 ( miR‐21 ) upregulated tissues than adjacent healthy patients. A significant inverse correlation between levels both tissues. The low level high were correlated with poor prognosis. overexpression casued...