A5108048871- Liver Disease and Transplantation
- Ion channel regulation and function
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Spine and Intervertebral Disc Pathology
- Pluripotent Stem Cells Research
- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Corrosion Behavior and Inhibition
- Organ Transplantation Techniques and Outcomes
- Glioma Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Neuroscience and Neuropharmacology Research
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Geotechnical Engineering and Soil Mechanics
- Bone Tissue Engineering Materials
- Quantum Chromodynamics and Particle Interactions
- Hydrogen embrittlement and corrosion behaviors in metals
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
Tongji Hospital
2013-2025
Wenzhou Medical University
2009-2025
Nanjing Medical University
2022-2025
Jiangsu Province Hospital
2022-2025
Xuzhou Medical College
2025
Huazhong University of Science and Technology
2015-2025
First Affiliated Hospital of Wenzhou Medical University
2009-2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Jinan University
2025
China-Japan Friendship Hospital
2025
OBJECTIVE To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve function during the course of streptozotocin (STZ)-induced diabetic nephropathy. RESEARCH DESIGN AND METHODS Diabetes was induced in Nrf2+/+ Nrf2−/− mice by STZ injection. Sulforaphane (SF) or cinnamic aldehyde (CA) administered weeks after injection metabolic indices structure were assessed (18 weeks). Markers diabetes including blood glucose,...
Combining whole exome sequencing, transcriptome profiling, and T cell repertoire analysis, we investigate the spatial features of surgically-removed biopsies from multiple loci in tumor masses 15 patients with non-small lung cancer (NSCLC). This revealed that immune microenvironment has high heterogeneity such intratumoral regional variation is as large inter-personal variation. While local total mutational burden (TMB) associated T-cell clonal expansion, anti-tumor cytotoxicity does not...
Prior randomized trials have generally shown harm or no benefit of stenting added to medical therapy for patients with symptomatic severe intracranial atherosclerotic stenosis, but it remains uncertain as whether refined patient selection and more experienced surgeons might result in improved outcomes.To compare plus vs alone stenosis.Multicenter, open-label, randomized, outcome assessor-blinded trial conducted at 8 centers China. A total 380 transient ischemic attack nondisabling,...
Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem leading factor undermines intrinsic repair and aggravates IDD. Previous research has separately studied effect of oxygen concentration mechanical loading in However, how these two factors synergistically influence remains unclear. Therefore, we established vitro vivo models to study mechanisms by which hypoxia interacted with...
Previous randomized clinical trials did not demonstrate the superiority of endovascular stenting over aggressive medical management for patients with symptomatic intracranial atherosclerotic stenosis (sICAS). However, balloon angioplasty has been investigated in a trial.
Abstract Hyperuricemia is common in China and the relevance of hyperuricemia cardiovascular disease (CVD) risk has been highlighted, but to date there rarely nation-wide study China. Here, we aim estimate current prevalence evaluate associations between factors (CRFs) clustering a large sample adults including plurality ethnic minorities. Generally, nationally representative 22983 aged ≥18 years was recruited from 2007 2011. Questionnaire data information on anthropometric characteristics,...
Abstract In Alzheimer’s disease (AD), sensome receptor dysfunction impairs microglial danger-associated molecular pattern (DAMP) clearance and exacerbates pathology. Although extrinsic signals, including interleukin-33 (IL-33), can restore DAMP clearance, it remains largely unclear how the is regulated interacts with during phagocytic clearance. Here, we show that IL-33 induces VCAM1 in microglia, which promotes chemotaxis toward amyloid-beta (Aβ) plaque-associated ApoE, leads to Aβ We...
Nucleus pulposus stem cells (NPSCs) senescence plays a critical role in the progression of intervertebral disc degeneration (IDD). Stem cell-derived extracellular vesicles (EV) alleviate cellular senescence. Whereas, underlying mechanism remains unclear. Low stability largely limited administration EV vivo. RGD, an arginine-glycine-aspartic acid tripeptide, strongly binds integrins expressed on membranes, allowing RGD to anchor and prolong their bioavailability. An RGD-complexed nucleus...
Abstract Intervertebral disc degeneration (IDD) is an age‐related disease and responsible for low back pain. Oxidative stress‐induced cell death plays a fundamental role in IDD pathogenesis. Cuproptosis recently discovered form of programmed dependent on copper availability. Whether cuproptosis involved progression remains unknown. Herein, we established vitro vivo models to investigate the mechanisms by which oxidative stress interacts with sensitivity nucleus pulposus cells (NPCs). We...
Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for managing portal hypertension in cirrhotic patients, but the impact of post-TIPS overt hepatic encephalopathy (OHE) on survival remains controversial. While its effect short-term well-documented, long-term implications remain unclear. This study aims to investigate OHE mortality patients variceal bleeding, focusing timing and predictive value beyond first year post-TIPS. A multicenter, retrospective cohort...
<h3>BACKGROUND AND PURPOSE:</h3> On the basis of high 1-month stroke and/or death (14.7%) rates associated with stent placement in Stenting versus Aggressive Medical Management for Preventing Recurrent Stroke Intracranial Stenosis trial, modifications patient selection and procedural aspects intracranial have been recommended. We performed a multicenter prospective single-arm trial to determine whether such would result lower periprocedural death. <h3>MATERIALS METHODS:</h3> The study...
Lung cancer is the most commonly diagnosed and accounts for cancer-related mortalities worldwide. The high expression of programmed death ligand 1 (PD-L1) an important factor that promotes immune escape lung cancer, thus aggravates chemotherapy resistance poor prognosis. Therefore, understanding regulatory mechanism PD-L1 in critical tumor immunotherapy. Enhancer Zeste homolog2 (EZH2), epigenetic molecule with histone methyltransferase activity, formation immunosuppressive microenvironment....
Abstract Exogenous stem cell therapy and endogenous repair has shown great potential in intervertebral disc regeneration. However, limited nutrients accumulation of lactate largely impair the survival regenerative capacity implanted cells nucleus pulposus (NPCs). Herein, an injectable hydrogel microsphere (LMGDNPs) have been developed by immersing oxidase (LOX)‐manganese dioxide (MnO 2 ) nanozyme (LM) into glucose‐enriched decellularized microspheres (GDNPs) through a microfluidic system....
BackgroundThe E1A-associated protein p300 (p300) has emerged as a promising target for cancer therapy due to its crucial role in promoting oncogenic signaling pathways various cancers, including prostate cancer. This need is particularly significant While androgen deprivation (ADT) demonstrated efficacy cancer, long-term use can eventually lead the development of castration-resistant (CRPC) and neuroendocrine (NEPC). Notably, been identified an important co-activator receptor (AR),...
ABSTRACT Nanopore sequencing, a third-generation sequencing technology, has revolutionized the gene industry with its advantages of long reads, fast speed, real-time and analysis, potential in detecting base modifications. This technology allows researchers to sequence longer DNA fragments single read, providing more comprehensive genomic information compared previous methods. operates on electrical signals generated by nanopore embedded membrane separating two electrolyte-filled chambers....