A5100649076- Glycosylation and Glycoproteins Research
- Toxin Mechanisms and Immunotoxins
- Galectins and Cancer Biology
- Medicinal Plant Pharmacodynamics Research
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Polysaccharides and Plant Cell Walls
- Acute Ischemic Stroke Management
- Monoclonal and Polyclonal Antibodies Research
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Pharmacological Effects of Natural Compounds
- Moyamoya disease diagnosis and treatment
- Vehicle emissions and performance
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Plant-based Medicinal Research
- Neurological Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Gut microbiota and health
- Proteoglycans and glycosaminoglycans research
- Traumatic Brain Injury and Neurovascular Disturbances
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Wnt/β-catenin signaling in development and cancer
Jiangsu T-mab BioPharma (China)
2024-2025
Chengdu Third People's Hospital
2024
Southwest Jiaotong University
2024
Hebei GEO University
2024
Tianjin Huanhu Hospital
1999-2023
Bioscience (China)
2023
The University of Tokyo
2023
Yangpu Hospital of Tongji University
2022
Weatherford College
2022
University of Wisconsin–Madison
2022
Prior randomized trials have generally shown harm or no benefit of stenting added to medical therapy for patients with symptomatic severe intracranial atherosclerotic stenosis, but it remains uncertain as whether refined patient selection and more experienced surgeons might result in improved outcomes.To compare plus vs alone stenosis.Multicenter, open-label, randomized, outcome assessor-blinded trial conducted at 8 centers China. A total 380 transient ischemic attack nondisabling,...
Abstract Overexpression of nectin cell adhesion protein 4 correlates with cancer progression and poor prognosis in many human malignancies. Enfortumab vedotin (EV) is the first nectin-4–targeting antibody–drug conjugate (ADC) approved by FDA for treatment urothelial cancer. However, inadequate efficacy has limited progress other solid tumors EV. Furthermore, ocular, pulmonary, hematologic toxic side effects are common nectin-4–targeted therapy, which frequently results dose reduction and/or...
Abstract Introduction: B7-H3, an attractive target for antibody drug conjugate, is overexpressed in multiple tumors. Overexpression of B7-H3 tumor cells frequently correlates with fewer tumor-infiltrating lymphocytes, faster cancer progression, and poor clinical outcome several malignancies. Preliminary evidence revealed PARP inhibitors (PARPi) B7-H3-directed antibody-drug conjugate (ADC) as two practical approaches to overcome chemoresistance solid cancers. Thus, synthetic lethality...
We designed and developed 9MW2821, an anti-Nectin-4 antibody–drug conjugate (ADC) with enzymatically cleavable valine–citrulline linker monomethyl auristatin E (MMAE) as the payload. Four bioanalytical assays for total antibodies, conjugated payload, free payload were then validated comprehensive evaluation of multiple drug forms 9MW2821. Specific sandwich enzyme-linked immunosorbent used to quantify antibodies antibody, showing good drug-to-antibody ratio (DAR) tolerance. Liquid...
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The endovascular coiling of very small ruptured aneurysms with difficult geometry presents a significant treatment challenge because potential dangerous complications, such as intraprocedural ruptures. We report our initial experience the use dual microcatheter technique, combined new hypersoft helical coils, for these lesions. Fourteen maximum diameter ≤3 mm that presented configurations, wide neck or an important branch vessel arising from fundus, were identified using digital subtraction...
Introduction The endovascular coiling of small ruptured aneurysms with difficult geometries presents a significant treatment challenge. We report our initial experience and the technical details dual microcatheter coil embolizations that were applied in these lesions. Method results Eighty-five (<7 mm) exhibited configurations, such as wide neck or an important branch vessel arising from fundus, successfully treated using technique. packing attenuation, adverse events during procedures,...
In this study we attempt to investigate the new role of docosahexaenoic acid (DHA) supplementation on cognitive ability in aged mice. Kunming-line mice were treated with DHA (200, 400 mg/kg body weight/day) for 30 successive days. The was assessed by learning and memory behavioral test; levels capillary gas chromatography; dopamine (DA), norepinephrine (NE), 5-hydroxytryptamine (5-HT) high-performance liquid brain-derived neurotrophic factor (BDNF) nerve growth (NGF) proteins enzyme-linked...
Outsourcing logical regression model to the cloud is highly beneficial, yet it will not only cause privacy issues due confidentiality of data, but also bandwidth and computing burden for cloud. In this paper, we design, implement evaluate a new system that allows secure cloud-edge collaborative logistic (SC-CLRM) based on multi-key fully homomorphic encryption (multi-key FHE). Our significantly shifts processing edge securely trains among multiple parties. We first propose scheme which uses...
Inflammatory bowel diseases (IBDs) are chronic inflammatory intestinal disorders that characterized by thickened colon walls, ulcerations, including two forms of ulcerative colitis (UC) and Crohn's disease (CD). UC CD share some similar clinico-pathological characteristics but their causes opposite. The imbalance in cytokinesis produced Th1 Th2 cells, the subunit CD4+ T plays a key role development IBDs. Although traditional treatment for IBDs is effective to patients, it has numerous...
Aims Soft and small coils are known to be appropriate for the treatment of aneurysms. The purpose this study was determine whether new HyperSoft® helical coil, which is softer smaller than its predecessors, has any effect on packing performance in a matched-pair with an old coil. Materials methods Thirty-six consecutive patients harboring 43 cerebral aneurysms treated HyperSofts were included study. Forty-one identified from our database as matched controls based similar volumes locations....
Postoperative epidural hematoma (POEDH) is a known complication after neurosurgical procedures. Large POEDHs are life-threatening and require emergency evacuation, open surgery the mainstay of treatment. Most hyperdense on computed tomography (CT). We herein report subset requiring which presented with isodense features CT. The presenting symptoms patients were severe headache accompanied by nausea vomiting as well unilateral limb weakness (n = 1) consciousness disorder 4). Glasgow coma...
High-resolution computed tomography (HR-CT) can more effectively discern the relationship between pituitary neoplasms (PNs) and neighboring anatomical structures. Moreover, pathological features facilitate a accurate determination of growth pattern PNs. Consequently, integrating imaging data might enhance our predictive capability regarding patterns PNs aid in formulation surgical plans. We compared HR-CT images 54 patients 52 volunteers. Using ITK-SNAP software, we segmented reconstructed...
Objective: The aim of this study was to conclude the safety and effectiveness hybrid surgery for revascularization chronic occlusion internal carotid artery (COICA). Methods: A total 56 COCIA patients underwent (carotid endarterectomy+carotid stenting) from September 2017 2021 in our department. clinical material radiology data (preoperation postoperation) were retrospectively analyzed COICA. Results: All got successfully (with a successful rate 100%) improved intracranial blood flow....
To explore the feasibility and safety of remote programming technology based on 5G cloud support platform in postoperative follow-up cardiovascular implantable electronic devices(CIED).