A5100719499- Glycosylation and Glycoproteins Research
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Ubiquitin and proteasome pathways
- Biosimilars and Bioanalytical Methods
- Ovarian cancer diagnosis and treatment
- vaccines and immunoinformatics approaches
- Biopolymer Synthesis and Applications
- Geotechnical Engineering and Soil Mechanics
- Nanofabrication and Lithography Techniques
- Milk Quality and Mastitis in Dairy Cows
- Thyroid Cancer Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Circular RNAs in diseases
- Cardiac tumors and thrombi
- Cavitation Phenomena in Pumps
- NF-κB Signaling Pathways
- Blood disorders and treatments
- Intensive Care Unit Cognitive Disorders
- Lymphatic System and Diseases
- Nutrition, Genetics, and Disease
- Childhood Cancer Survivors' Quality of Life
- Bone Metabolism and Diseases
Air Force Medical University
2004-2023
Xijing Hospital
2003-2023
City of Hope
2023
Tibet University
2021
Lanzhou University of Technology
2019
Hospital of Hebei Province
2011
Shanghai Institute of Materia Medica
2005
Chinese Academy of Sciences
2005
Limitation of 3D construction ability, complex preparation processes and developing customer demands have promoted people to find low-cost, rapid prototyping, simple operation methods produce novel functional devices in the near future. Among various techniques, 3D-printed technology is a promising candidate for fabrication biosensors biomedical detection with wide variety potential applications. This review offers four important printing techniques their The principle process technologies...
Ubiquitin-specific protease 22 (USP22), a novel deubiquitinating enzyme, has been associated with metastasis, therapy resistance, and cell cycle progression. The purpose of this study was to investigate the expression level USP22 in papillary thyroid carcinoma (PTC) samples evaluate its clinical significance PTC patients. examined 30 fresh tissues paired adjacent noncancerous by real-time quantitative RT-PCR. Immunohistochemistry for performed on additional 156 tissues. analyzed. We found...
Volatile anesthetic isoflurane (ISO) has immunomodulatory effects. The fungal component zymosan (ZY) induces inflammation through toll-like receptor 2 or dectin-1 signaling. We investigated the molecular actions of subanesthetic (0.7%) ISO against ZY-induced inflammatory activation in murine Kupffer cells (KCs), which are known as resident macrophages within liver. observed that reduced cyclooxygenase upregulation and prostaglandin E release, determined by western blot radioimmunoassay,...
AIM:To investigate the relation between MUC1 expression, distribution, and prognosis in hepatocellular cholangiocarcinoma (HCC CC) cirrhotic liver tissues, their significance HCC CC diagnosis. METHODS:Expression distribution of were examined by immunohistochemical assay with anti-MUC1 mAb 59 samples 37 CC, 20 10 normal seeking possible associations positive (primary cancer, PLC) cases studied clinical data. RESULTS: Immunohistochemical analysis MUC1expression showed that 96 PLC samples, 68...
Lymphatic metastasis is the predominant cause of low overall survival patients with esophageal squamous cell carcinoma (ESCC), as there are no faithful methods available predicting early metastasis. Recent studies suggest an effect podoplanin expression on metastatic spreading to lymph nodes. The purpose this study was investigate influence lymphatic and tumor cells, find relationship between prognosis ESCC. We evaluated level cells vessel density change mass compared normal tissue from same...
Anesthetic isoflurane (ISO) has immunomodulatory effects. In the present study, we investigated whether a subanesthetic dose of ISO (0.7%) protected against zymosan (ZY) induced inflammatory responses in murine lung and isolated neutrophils. At 1 6 hrs after ZY administration intraperitoneally, was inhaled for hr, 24 later, inflammation injury were assessed. We found that improved survival rate mice mitigated as characterized by histopathology, wet-to-dry weight ratio, protein leakage,...
Many approaches targeting MUC1 for breast tumor immunotherapy have been attempted. However, preclinical trials with showed that is a relatively poor immunogen in human. B7 molecules bind CD28 provide an antigen-nonspecific signal, which, along antigen-specific crucial T-cell activation. In the present study, we constructed novel Bacillus Calmette-Guérin-based cancer vaccine coexpressed four VNTRs (variable-number tandem repeats) of and CD80 (rBCG-MVNTR4-CD80). The aim our study was to...
In this study, we constructed several novel breast cancer vaccines, Bacillus Calmette-Guérin (BCG)-MUC1 variable-number tandem repeats (VNTR) 1/4/8-CSF, that consist of BCG and express 1, 4, 8 the MUC1 human granulocyte-macrophage colony-stimulating factor (GM-CSF). The ability three recombinant vaccines to inhibit growth was observed in (hu)-peripheral blood lymphocyte (PBL)-severe combined immunodeficient (SCID) mice. Prophylactic protective responses were successfully induced tumor...
By identifying the clinicopathological characteristics and prognostic influences of patients with triple-positive breast cancer (TPBC) at Xijing Hospital in China compared those United States, this study aims to construct a nomogram model forecast overall survival rate (OS) TPBC patients. The Surveillance, Epidemiology, End Results (SEER) database was used screen 5769 as training cohort, 191 from were validation cohort. Cox risk-proportional applied select variables constructed based on...
Primary sarcoma of the aorta is extremely rare and accounts for <1% all sarcomas. The present study describes case a 45‑year‑old male who presented with lower limb abdominal pain. Abdominal computed tomography (CT) magnetic resonance (MR) arteriography revealed tumor that extended from infrarenal to aortic bifurcation. external internal iliac arteries were occluded by incursion. Palliative surgery was performed since patient refused radical resection. To improve blood supply limbs, an...
The aim of this study is to establish an orthotopic implantation nude mouse model epithelial ovarian cancer (EOC) and observe its biologic features. A human tumor line SKOV3ipl previously grown subcutaneously was implanted orthotopically as intact tissue into the capsule 64 mice. Every week eight mice were taken randomly, growth pattern extent metastatic disease monitored continuously. Those that died necropsied end date recorded. tumors demonstrated a 100% take rate. Three weeks after grew...
In order to study the spiral gas-liquid mixing loss and noise characteristics of oil-gas transportation screw-axial pump, with pump as research object, based on RNG k–ε psilon internal unsteady flow model simulate parameter change gas liquid delivery information, extract transfer information parameters pressure fluctuation signals, using acoustic software LMS Virtual Lab IBEM indirect boundary element method is used solve helical axial multiphase mixture pumps in dipole source caused by...