A5102929420- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Gastric Cancer Management and Outcomes
- NF-κB Signaling Pathways
- Esophageal Cancer Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Screening and Detection
Shenyang Center for Disease Control and Prevention
2022
First Hospital of China Medical University
2021
China Medical University
2021
Shandong University
2018-2019
Shandong Center for Disease Control and Prevention
2018-2019
Shandong Provincial Hospital
2018-2019
Carvedilol has been identified as a promising agent for the treatment of liver fibrosis. Meanwhile, autophagy and apoptosis have reported to play key roles in activation hepatic stellate cells (HSCs), which can contribute progression However, effects carvedilol on HSCs remain unclear. Our study aimed detect these identify underlying mechanisms by mediates HSC apoptosis. For this purpose, LX-2 cell line was used study, were exposed various concentrations specific times. First, we found that...
To investigate the effect of carvedilol on liver fibrosis and hepatic sinusoidal capillarization in mice with carbon tetrachloride (CCl4)-induced fibrosis.A mouse model was induced by intraperitoneal CCl4 injection for 8 weeks. The were divided into five experimental groups: normal group, oil CCl4+carvedilol (5 mg/kg/d) (10 group. extent evaluated histopathological staining, changes fenestrations sinus endothelial cells observed scanning electron microscope (SEM). expression α-smooth muscle...
To investigate the effect of metformin on activated hepatic stellate cells (HSCs) and possible signaling pathways involved.A fibrotic mouse model was generated by intraperitoneal injection carbon tetrachloride (CCl4) subsequent treatment with or without metformin. The level fibrosis detected hematoxylin-eosin staining, Sirius Red immunohistochemistry. HSC cell line LX-2 used for in vitro studies. proliferation (CCK8 assay), motility (scratch test Transwell contraction (collagen gel...
Carvedilol is a nonselective beta-blocker used to reduce portal hypertension. This study investigated the effects and potential mechanisms of carvedilol in angiotensin II- (Ang II-) induced hepatic stellate cell (HSC) proliferation contraction.The effect on HSC was measured by Cell Counting Kit-8 (CCK-8). cycle progression apoptosis HSCs were determined flow cytometry. A collagen gel assay confirm contraction. The extent liver fibrosis mice evaluated hematoxylin-eosin (H&E) Sirius Red...
Background Interleukin 20 receptor A (IL20RA) has been shown to play a role in the establishment and progression of multiple tumors. However, expression this protein colorectal cancer (CRC) its correlation with clinicopathological parameters CRC have remained unclear. Methods total 323 paraffin sections including tissues adjacent normal after surgery were collected. IL20RA was detected by immunohistochemical staining. The difference mRNA between also explored Oncomine GEO databases. In...
The strategy for upper gastrointestinal cancer (UGC) screening has not yet been determined, especially in northeast China.The sample was from an ongoing prospective population-based cohort screening.This study belonged to the Chinese Urban Cancer Screening Program. analysis based on recruitment of participants aged 40-74 Northeast China 2016 2017. Totally, 39 369 eligible were recruited, 8772 evaluated be at high risk UGC, 1957 underwent endoscopy.χ2 test and multifactor logistic regression...