A5009236084- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Digestive system and related health
- Eosinophilic Esophagitis
- Veterinary medicine and infectious diseases
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
- Gut microbiota and health
- Wnt/β-catenin signaling in development and cancer
- Caveolin-1 and cellular processes
- Plant Stress Responses and Tolerance
- Bone and Dental Protein Studies
- Cancer-related gene regulation
- Signaling Pathways in Disease
- DNA Repair Mechanisms
- Peptidase Inhibition and Analysis
- Aortic Disease and Treatment Approaches
- Gastroesophageal reflux and treatments
- Garlic and Onion Studies
- Plant Molecular Biology Research
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
China Medical University
2016-2025
First Hospital of China Medical University
2011-2025
Liaoning Cancer Hospital & Institute
2017-2024
Dalian University of Technology
2024
Shanghai First People's Hospital
2016-2019
Shanghai Jiao Tong University
2019
Yibin University
2015-2018
National Clinical Research Center for Digestive Diseases
2018
Purdue University West Lafayette
2015-2016
Emory University
2013
Significance We identified transgenic plants that are extremely resistant to drought from a large-scale screening of overexpressing the pyrabactin resistance 1-like (PYL) family abscisic acid (ABA) receptors. explored how these resist by examining both short-term responses, such as stomatal closure, and long-term senescence. The physiological roles ABA-induced senescence under stress conditions underlying molecular mechanism unclear. Here, we found ABA induces activating ABA-responsive...
The link between microbiota and gastric cancer (GC) has attracted widespread attention. However, the phylogenetic profiles of niche-specific in tumor microenvironment is still unclear. Here, mucosa-associated microorganisms from 62 pairs matched GC tissues adjacent non-cancerous were characterized by 16S rRNA gene sequencing. Functional predicted using PICRUSt, a co-occurrence network was constructed to analyze interactions among microbiota. Results demonstrated that cancerous established...
Objectives: We aimed to assess a serological biopsy using five stomach-specific circulating biomarkers—pepsinogen I (PGI), PGII, PGI/II ratio, anti-Helicobacter pylori (H. pylori)antibody, and gastrin-17 (G-17)—for identifying high-risk individuals predicting risk of developing gastric cancer (GC). Methods: Among 12,112 participants with prospective follow-up from an ongoing population-based screening program both serology gastroscopy in China, we conducted multi-phase study involving...
H. pylori exhibits antibiotic resistance with regional differences. In this paper, we explored of to five antibiotics in an area a high risk gastric cancer. rates metronidazole, levofloxacin, clarithromycin, amoxicillin, and tetracycline were 78.0, 56.0, 31.0, 9.0, 15.0%, respectively. Double, triple, quadruple, quintuple 23, 20, 6, 4%, The clarithromycin multidrug significantly higher males than females (clarithromycin: 44.4% vs 15.2%, respectively, P = 0.002; multidrug: 75.5% 37.2%,...
Helicobacter pylori (H. pylori) antibiotic resistance poses a global health threat. Accurate identification of resistant strains is essential for the control infection. In present study, our goal to leverage whole-genome data H. develop practical and interpretable machine learning (ML) models comprehensive assessment. A total 296 isolates with genome-wide were downloaded from Bacterial Viral Bioinformatics Resource Center (BV-BRC) National Biotechnology Information (NCBI) databases. By...
Summary The C‐ REPEAT ‐ BINDING FACTOR ( CBF ) pathway has important roles in plant responses to cold stress. How the genes themselves are activated after acclimation remains poorly understood. In this study, we characterized tolerance of null mutant RNA DIRECTED DNA METHYLATION 4 RDM ), which encodes a protein that associates with polymerases Pol V and II , is required for ‐directed methylation (Rd DM Arabidopsis . results showed dysfunction reduced tolerance, as evidenced by decreased...
Abstract Background Gastric intestinal metaplasia (GIM) represents an important precancerous lesion in intestinal-type gastric cancer, triggered by persistent Helicobacter pylori ( H. ) infection. In a previous study, we unveiled SlyD as novel virulence factor of , establishing its role GIM induction through TPT1. However, the underlying mechanism remains undetermined. Methods epithelial cells were stimulated with 26695, inactivated mutant (ΔSlyD), and purified HpSlyD protein, respectively....
<title>Abstract</title> <bold>Background</bold> Neoadjuvant chemotherapy (NCT) is a cornerstone treatment for locally advanced gastric cancer (LAGC), yet patient responses vary significantly. This study aimed to develop and validate general clinical model predict NCT efficacy in LAGC patients. <bold>Methods</bold> A systematic review meta-analysis were performed identify independent features associated with efficacy. Using <italic>β</italic> coefficients, risk score-based predictive was...
Objective: This study mainly focused on revealing ceRNA network in gastric cancer (GC) with Hp infection after comparing GC without and exploring the biological function prognostic relevance of related molecules. Methods: The RNA expression profile data patients or were extracted from TCGA GDC portal, including 20 cases 168 infection. Differentially expressed lncRNAs, miRNAs mRNAs unveiled by package edgeR R, lncRNA-miRNA-mRNA was constructed integrating miRNA target information mRNAs. Gene...
Serum pepsinogen II (sPGII) is underutilized and considered an inconspicuous biomarker in clinical practice. We refocused on this neglected but novel conducted the present study, aiming to elucidate normal level of sPGII healthy Chinese patients investigate utility for gastric disease screening.In 2008-2009, a total 2022 participants from northern China were selected enrolled study. Helicobacter pylori (H. pylori)-immunoglobulin G measured with ELISA.sPGII showed value 6.6 microg/L 466...
Effectively managing precancerous lesions is crucial to reducing the gastric cancer (GC) burden. We evaluated associations of temporal changes in multiple serological markers (pepsinogen I [PGI], PGII, PGI/II ratio, gastrin-17 and anti-Helicobacter pylori IgG) with risk for progression lesions. From 1997 2011, repeated esophagogastroduodenoscopies mucosal biopsies blood sample collections were conducted on 2,039 participants (5,070 person-visits) Zhuanghe Gastric Diseases Screening Program,...
Objective:The microsatellite status and tumor immune microenvironment have a remarkable influence on immunotherapy.This study was performed to investigate programmed cell death protein 1/programmed ligand 1 (PD1/PDL1) expression their correlations with CD8+ T cell/CD68+ macrophage (CD68+ M) densities in gastric cancer (GC) at different statuses.Methods: The of MLH1, PMS2, MSH2, MSH6 detected via immunohistochemistry (IHC) determine the 215 GC samples obtained from surgical...
Objective. Clinical implications of serum anti-Helicobacter pylori immunoglobulin G (IgG) titer were unclear. This study investigated the associations anti-H. IgG with grade histological gastritis, mucosal bacterial density and levels biomarkers, including pepsinogen (PG) I, PGII, PGI/II ratio gastrin-17. Material methods. Study participants from a screening program in northern China. Serum measurements available for 5922 patients superficial gastritis. biomarkers measured using ELISA,...
Subclass III members of the sucrose non-fermenting-1-related protein kinase 2 (SnRK2) play essential roles in both ABA signaling and abiotic stress responses plants by phosphorylating downstream ABA-responsive element (ABRE)-binding proteins (AREB/ABFs). This comprehensive study investigated function new candidate genes, namely SmSnRK2.3, SmSnRK2.6, SmAREB1, with a view to breeding novel varieties Salvia miltiorrhiza improved tolerance stresses more content bioactive ingredients. Exogenous...
Gastric cancer (GC) development trends have identified multiple processes ranging from inflammation to carcinogenesis, however, key pathogenic mechanisms remain unclear. Tissue microenvironment (TME) cells are critical for the progression of malignant tumors. Here, we generated a dynamic transcriptome map various TME during multi-disease stages using single-cell sequencing analysis. We observed set transition markers related cell carcinogenic evolution, and delineated landmark trajectories...
AIM:To explore the essential characteristics of serum pepsinogen (PG) levels in Chinese people, by analyzing population-based data on PG Ⅰ and Ⅱ PGⅠ/Ⅱ ratio, their influencing factors from North China. METHODS:A total 6990 subjects, who underwent a gastric cancer screening China 1997 to 2002, were collected this study.Serum measured enzyme-linked immunosorbent assay (ELISA).H pylori status was determined histological examination H -IgG ELISA.The cut-off point calculated using receiving...
Glutathione S-transferase P1 (GSTP1) is a critical enzyme in the phase II detoxification pathway. One of common functional polymorphisms GSTP1 A→G at nucleotide 313, which results an amino acid substitution (Ile105Val) substrate binding site and reduced catalytic activity. We evaluated interaction between Val allele Helicobacter pylori infection, smoking alcohol consumption, increasing risk gastric cancer among Chinese population. Information on potential factors blood specimens were...
Background and aim. Fasting serum gastrin-17 (FsG17) is considered as a noninvasive biomarker reflecting the structure functional status of gastric mucosa, but its clinical utility remains unclear. This study aimed to evaluate FsG17 comprehensively: establish ranges cut-off points levels in different diseases, identify their influencing factors, investigate accuracy for identifying diseased stomach. Methods. The included 4064 participants from Northern China between 2008 2013. Helicobacter...