A5116130598- Esophageal Cancer Research and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Gut microbiota and health
- Medical Imaging and Pathology Studies
- Cancer-related molecular mechanisms research
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Neonatal Respiratory Health Research
- Helicobacter pylori-related gastroenterology studies
- Pulmonary Hypertension Research and Treatments
- Acute Myocardial Infarction Research
- Eosinophilic Esophagitis
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Liver Disease and Transplantation
- Prostate Cancer Treatment and Research
Yancheng Central Blood Station
2025
Guangzhou University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Peking University
2011-2025
Peking University People's Hospital
2011-2025
Nankai University
2019-2025
Changzhou University
2024-2025
Henan Normal University
2009-2024
Shanghai Pulmonary Hospital
2022-2024
Inflammatory bowel disease (IBD) is defined as an immune dysregulation with poor prognosis. Various therapies based on gut microbe modulation have been proposed. In this study, we aim to explore the therapeutic effect of B. adolescentis IBD, well and microecology mechanism in IBD. The fecal level was decreased IBD patients compared normal people our cohort GMrepo database. To further clarify role induced chronic colitis three cycles dextran sulfate sodium (DSS). We found gavage exhibited...
The androgen receptor (AR) is required for castration-resistant prostate cancer (CRPC) progression, but the function and disease relevance of AR-bound enhancers remain unclear. Here, we identify a group AR-regulated enhancer RNAs (e.g., PSA eRNA) that are upregulated in CRPC cells, patient-derived xenografts (PDXs), patient tissues. eRNA binds to CYCLIN T1, activates P-TEFb, promotes cis trans target gene transcription by increasing serine-2 phosphorylation RNA polymerase II (Pol II-Ser2p)....
Alterations in gut microbiota are postulated to be an etiologic factor the pathogenesis of irritable bowel syndrome (IBS). To determine whether IBS patients China exhibited differences their microbial composition, fecal samples were collected from diarrhea-predominant (IBS-D) and healthy controls evaluated by 16S ribosomal RNA gene sequence quantitative real-time PCR. A mouse model postinfectious (PI-IBS) was established altered associated with increased visceral hypersensitivity. The...
Abstract Background Matrix metalloproteinases (MMPs) play important roles in remodeling the extracellular matrix and pathogenesis of idiopathic pulmonary fibrosis (IPF). MMP19, which is an MMP, was significantly upregulated hyperplastic alveolar epithelial cells IPF lung tissues promoted epithelial-mesenchymal transition (EMT). Recent studies have demonstrated that endothelial-to-mesenchymal (E(nd)MT) contributes to fibrosis. However, role MMP19 vascular injury repair E(nd)MT remains...
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal, and aging-associated interstitial lung disease with poor prognosis limited treatment options, while the pathogenesis remains elusive. In this study, we found that expression of nuclear receptor subfamily 2 group F member (NR2F2), steroid thyroid hormone superfamily receptors, was reduced in both IPF bleomycin-induced fibrotic lungs, markedly senescent epithelial cells. Inhibition NR2F2 increased senescence markers...
Oxidative stress plays a critical role in the development of cardiac remodeling and heart failure. Lutein, predominant nonvitamin A carotenoid, has been shown to have profound effects on oxidative stress. However, effect lutein angiotensin II (Ang II)-induced failure remains unknown. The aim this study was determine whether is involved elucidate underlying molecular mechanisms. In vitro experiments with isolated neonatal rat cardiomyocytes (NRCMs) fibroblasts (CFs) revealed that...
The heterogeneity of idiopathic pulmonary fibrosis (IPF) limits its diagnosis and treatment. association between the pathophysiological features serum protein signatures IPF currently remains unclear. present study analyzed specific proteins patterns associated with clinical parameters based on a proteomic dataset by data-independent acquisition using MS. Differentiated in sera distinguished patients into three subgroups signal pathways overall survival. Aging-associated weighted gene...
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal interstitial lung disease without an effective cure. Herein, we explore the role of 3,5,3′-triiodothyronine (T3) administration on alveolar regeneration and at single-cell level. T3 supplementation significantly altered gene expression in fibrotic tissues. Immune cells were rapidly recruited into after injury; there much more M2 macrophages than M1 lungs bleomycin-treated mice; increased slightly, whereas reduced treatment. enhanced...
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease characterized by excessive deposition of fibrotic connective tissue in the lungs. Emerging evidence suggests that metabolic alterations, particularly glycolysis reprogramming, play crucial role pathogenesis IPF. Lactate, once considered waste product, now recognized as signaling molecule involved various cellular processes. In context IPF, lactate has been shown to promote fibroblast activation, myofibroblast...
This study aims to investigate whether the Dietary Inflammatory Index (DII) is associated with non-alcoholic fatty liver disease (NAFLD) and advanced hepatic fibrosis (AHF) among non-institutionalized adults in United States.Utilizing data from National Health Nutrition Examination Survey (NHANES) 2005 2016, a total of 10,052 aged ≥18 years were included analysis. We used multivariable analysis, controlling for demographic variables, evaluate association between DII NAFLD AHF, restricted...
Several biomarkers are used in confirming the diagnosis of cognitive disorders. This study evaluates whether level these markers after heart surgery correlates with development dysfunction, which is a frequent complication cardiac interventions. Concentrations amyloid-β peptide, tau, and S100β cerebro-spinal fluid were assessed, as well functions evaluated before coronary artery bypass grafting, utilizing immuno-assays psychometric tests, respectively. A drastic rise was observed one week...
This study was undertaken to discover novel biomarkers for the noninvasive early diagnosis of nonalcoholic fatty liver disease (NAFLD). A methionine and choline deficient (MCD) diet used represent different stages NAFLD in male C57BL/6 mice. 1H NMR spectroscopy principal components analysis (PCA) were investigate time-related biochemical changes mice sera induced by MCD diet. Many serum metabolites' concentrations changed between control MCD-fed Hierarchical cluster (HCA) artificial neural...
MicroRNAs (miRNAs) play key roles in cancer development and progression. In the present study, we investigated role of miR-145 progression hepatocellular carcinoma (HCC). Ten HCC cell lines samples from 96 patients with were analyzed for expression by quantitative real-time polymerase chain reaction (qRT-PCR). Overexpression was established transfecting mimics into HepG2 QGY-7703 cells. Cell proliferation migration assessed viability assay transwell assay. Western blot to verify ROCK1 as a...
Abstract Non‐small‐cell lung cancer (NSCLC) is the most common malignancy along with high mortality rate worldwide. Recently, nucleolar and spindle‐associated protein 1 (NUSAP1) has been reported to be involved in malignant progression of several cancers. However, NSCLC, biological function NUSAP1 its molecular mechanism have not reported. Here, our findings indicated that messenger RNA expression level was remarkably upregulated NSCLC tissues compared adjacent normal tissues. We also found...
Abstract Fusion genes (FGs) are important genetic abnormalities in acute leukemias, but their variety and occurrence leukemias remain to be systematically described. Whole transcriptome sequencing (WTS) provides a powerful tool for analyzing FGs. Here we report the FG map revealed by WTS consecutive cohort of 1000 leukemia cases single center, including 539 myeloid (AML), 437 lymphoblastic (ALL), 24 mixed-phenotype (MPAL) patients. Bioinformatic analysis identified 792 high-confidence...
Double-agent intravenous chemotherapy concurrent with radiotherapy is the standard of care for patients inoperable esophageal cancer. However, tend to tolerate less well age and comorbidities. It essential find a better treatment modality that improves survival outcomes without reducing quality life.To evaluate effectiveness simultaneous integrated boost (SIB-RT) consolidated oral S-1 aged 70 years older squamous cell carcinoma (ESCC).This multicenter, phase III randomized clinical trial was...
We carried out a detailed exposure assessment of benzene and toluene in two shoe factories Tianjin, China. Our goal was to identify workers with broad range exposures, for an epidemiologic study relating early biologic effects.A comprehensive survey program initiated. Over period 16 months, 2783 personal solvent samples were collected workplaces from 250 workers. Mixed-effects models used factors affecting exposure. Principal component analyses (PCA) subsequent regression on the scores...