A5010215889- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Infant Health and Development
- Gastroesophageal reflux and treatments
- Congenital gastrointestinal and neural anomalies
- Eosinophilic Esophagitis
- Digestive system and related health
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Celiac Disease Research and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Dermatology and Skin Diseases
- Colorectal Cancer Screening and Detection
- Whipple's Disease and Interleukins
- Protein Tyrosine Phosphatases
- Myasthenia Gravis and Thymoma
- Trypanosoma species research and implications
- Phagocytosis and Immune Regulation
- Ferroptosis and cancer prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Bioactive Compounds and Antitumor Agents
- Venous Thromboembolism Diagnosis and Management
- Lysosomal Storage Disorders Research
- COVID-19 and healthcare impacts
Sir Run Run Shaw Hospital
2016-2025
Zhejiang University
2016-2025
Mianyang Central Hospital
2025
University of Electronic Science and Technology of China
2025
Shanxi Provincial Children's Hospital
2024
Health First
2024
Cancer Hospital of Chinese Academy of Medical Sciences
2021
University of Chinese Academy of Sciences
2021
Zhejiang Cancer Hospital
2021
Southern Medical University
2021
Alterations in gut microbiota are postulated to be an etiologic factor the pathogenesis of irritable bowel syndrome (IBS). To determine whether IBS patients China exhibited differences their microbial composition, fecal samples were collected from diarrhea-predominant (IBS-D) and healthy controls evaluated by 16S ribosomal RNA gene sequence quantitative real-time PCR. A mouse model postinfectious (PI-IBS) was established altered associated with increased visceral hypersensitivity. The...
Abstract Functional dyspepsia (FD) is a functional gastrointestinal disorder diagnosed by symptom-based criteria. It has been said that duodenal immune activation plays role in the pathogenesis of FD. The primary aims study were to compare total number eosinophil and evaluate degranulation rate, degranulated mast cell between patients with FD healthy subjects. We enrolled 96 24 controls at Sir Run Shaw Hospital. was comparable second portion duodenum (D2) bulb (D1) (all P > 0.05)....
INTRODUCTION: Slow colon transit and visceral hypersensitivity are recognized as major pathophysiological mechanisms in irritable bowel syndrome with constipation (IBS-C). However, there is a lack of therapies targeting both abdominal pain colonic motility. This study was designed to investigate the long-term effects possible transcutaneous electrical acustimulation (TEA) patients IBS-C. METHODS: Fifty-two IBS-C were randomized into 2 groups: daily TEA for 4 weeks (n = 26) sham-TEA 26). The...
AIMTo determine whether fructo-oligosaccharide (FOS) affects visceral sensitivity, inflammation, and production of intestinal short-chain fatty acids (SCFA) in an irritable bowel syndrome (IBS) mouse model. METHODSMice were randomly assigned to daily oral gavage saline solution with or without FOS (8 g/kg body weight) for 14 d.Mice further receive either one-hour water avoidance stress (WAS) sham-
Objective: To describe the epidemiological characteristics of bladder cancer in 2015 and temporal trends China. Methods: From 501 registries China, we collected data new cases, deaths populations 2015. After qualified, sex-specific, area-specific, age-specific overall incidence/mortality rates (including age-standardized by Chinese standard population world population) estimated cases were calculated. Annual Percent Change (APC)/Average (AAPC) fitted from Log-line model was applied to...
Abstract Background Alterations in intestinal permeability regulated by tight junctions (TJs) are associated with immune activation and visceral hypersensitivity irritable bowel syndrome ( IBS ). Myosin light chain kinase MLCK ) is an important mediator of epithelial TJ. The aim this study to investigate the role pathogenesis using a post infectious PI ‐ mouse model. Methods Trichinella spiralis‐ infected model was used. Urine lactulose/mannitol ratio measured assess permeability. Western...
The impact of marital status on survival among patients with esophageal cancer has not been evaluated in the U.S. population depth. aim study was to investigate diagnosed cancer. Surveillance, Epidemiology, and End Results (SEER) database utilized identify between 1973 2013. Cox regression analysis performed evaluate for association both cancer-specific overall survival. Of 69,139 cancer, 35,863 (52%) had adenocarcinoma 21,573 (31%) distant SEER stage. At time diagnosis, 39,805 (57%) were...
Dietary factors and immune dysfunction may induce symptoms in patients with functional dyspepsia (FD). The aim of the study was to evaluate whether gluten consumption impacts symptom onset FD for possible histologic alterations duodenum FD.We prospectively enrolled 101 newly diagnosed 31 asymptomatic controls. Specific patterns were evaluated by self-reported questionnaires. Tight junction protein (claudin-1) expression presence intraepithelial lymphocyte (IEL) infiltration bulb (D1) second...
Small intestinal bacterial overgrowth (SIBO) has been implicated in the pathogenesis of irritable bowel syndrome (IBS). Psychosocial factors and low-grade colonic mucosal immune activation have suggested to play important roles pathophysiology IBS. In total, 94 patients with IBS 13 healthy volunteers underwent a 10 g lactulose hydrogen breath test (HBT) concurrent<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mrow><mml:mi...
Abstract Background: Traditional treatment of functional dyspepsia (FD) is unsatisfactory in a subgroup patients with FD, and the potential role antidepressant medications also has not been definitely clarified. To provide more evidence for future optimal practice recommendations, we reviewed 1-year clinical database agents applied outpatients FD. Methods: Clinical presentations, course, outcomes were determined by chart review referring to gastrointestinal disorders specialist clinic. One...
Intestinal dysmotility and immune activation are likely involved in the pathogenesis of small intestinal bacteria overgrowth (SIBO) irritable bowel syndrome (IBS). We aimed at investigating role interstitial cells Cajal (ICC) inflammation development SIBO using a post-infectious IBS (PI-IBS) mouse model.NIH mice were randomly infected with Trichinella spiralis. Visceral sensitivity stool pattern assessed 8-weeks post-infection (PI). counts from jejunum ileum measured by quantitative...