A5100692583- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Diet and metabolism studies
- Nitric Oxide and Endothelin Effects
- Dermatology and Skin Diseases
- Blood Pressure and Hypertension Studies
- Cannabis and Cannabinoid Research
- Body Contouring and Surgery
- Antioxidants, Aging, Portulaca oleracea
- Respiratory and Cough-Related Research
- Infant Health and Development
- Antiplatelet Therapy and Cardiovascular Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Dietary Effects on Health
- Circadian rhythm and melatonin
- Respiratory Support and Mechanisms
- Cardiovascular Function and Risk Factors
- Glaucoma and retinal disorders
- Neuroendocrine Tumor Research Advances
- Gut microbiota and health
- Vasculitis and related conditions
- Diet, Metabolism, and Disease
- Eicosanoids and Hypertension Pharmacology
- Sodium Intake and Health
University of Michigan
2020-2024
Ningxia Medical University
2023
Nanjing Medical University
2022
Zhejiang University
2014-2021
Sir Run Run Shaw Hospital
2017-2021
Beijing National Laboratory for Molecular Sciences
2020
Chinese Academy of Sciences
2020
Peking University
2020
Peking University Third Hospital
2020
Tianjin University of Science and Technology
2020
Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) are carbohydrates thought to contribute the symptoms of IBS. A diet in high FODMAPs (HFM) induces gastrointestinal patients with irritable bowel syndrome (IBS), a low (LFM) improves up 60% However, mechanism by which affect IBS is unclear. We showed that mice fed on HFM have mast cell activation colonic barrier loss. Using cell-deficient without reconstitution, we HFM-mediated loss dependent TLR4-dependent...
AIMTo determine whether fructo-oligosaccharide (FOS) affects visceral sensitivity, inflammation, and production of intestinal short-chain fatty acids (SCFA) in an irritable bowel syndrome (IBS) mouse model. METHODSMice were randomly assigned to daily oral gavage saline solution with or without FOS (8 g/kg body weight) for 14 d.Mice further receive either one-hour water avoidance stress (WAS) sham-
We have investigated the effects of endothelin-1 (ET1) on phospholipid hydrolysis and 3H-arachidonic acid (AA) release prostaglandin synthesis in rabbit iris sphincter smooth muscle. ET1 actions are concentration- time dependent with an EC50 for AA 1 nM ti value 1.5 min. identified metabolites released by ET1, employing HPLC, as both cyclooxygenase lipoxygenase products. The appears to derive mainly from phosphoinositides through phospholipase A2, rather than C activation. A key role A2...
Aging is an important risk factor for neurodegenerative diseases. The activation of α7 nicotinic acetylcholine receptor (α7nAChR) involved in inflammation and cognition, but the specific role it plays aging remains unknown. This study aimed to investigate anti-aging effect α7nAChR on rats BV2 cells induced by D-galactose, as well its potential mechanism. D-galactose increase SA-β-Gal positive cells, expression p16 p21 vivo vitro. selective agonist PNU282987 decreased levels pro-inflammatory...
Proton pump inhibitors (PPIs) are the mainstay of therapy for gastroesophageal reflux disease (GERD) but up to 60% patients have inadequate response therapy. Acid sensing ion channels (ASICs) play important roles in nociception. This study aimed investigate whether increased expression ASICs results neuronal hyperexcitability GERD. Esophageal biopsies were taken from GERD and healthy subjects compare ASIC1 3. Next, gene protein 3 esophageal mucosa dorsal root ganglia (DRG) neurons measured...
Reliable country-specific incidence and cost data on diabetes-related complications are essential inputs for the projections of economic burden diabetes. The aim this study was to provide patient-level estimates managing treating in patients newly diagnosed with type 2 diabetes mellitus (T2DM) China. Patients T2DM Tianjin Urban Employee Basic Medical Insurance Claims database between 2008 2015 were identified followed up. cumulative descriptive costs certain macrovascular microvascular...
Increased use of multislice computed tomography (CT) scans has revealed that minute pulmonary meningothelial-like nodules (MPMNs) showed as ground-glass (GGNs) are frequent in patients. However, little is known about the incidence and fate nodules. By using a cross-sectional design, this study compared CT signs pathological results MPMNs, further used to explain formation mechanism MPMNs improve clinical understanding disease.The clinicopathological data 93 cases diagnosed Jiangsu Province...
Health and Social risks related to marijuana alcohol are a serious problem in the United States. This research tried introduce OLS regression order figure out correlation between use of cannabis, trend before after legalization which is factor that has not been researched previous literature alcohol, while lot controls were added model. It finds there higher likelihood for users co-use but people tend consume less if legal. may be because booster effect cannabis on alcohol. These results...
Background: Surgical decompression after acute spinal cord injury has become the consensus of orthopaedic surgeons.However, choice surgical time window been one most controversial topics in orthopaedics.Objective: We apply an online electrochemical system (OECS) for continuously monitoring ascorbate rats' to determine extent which levels were influenced by contusion or sustained compression.Methods: Adult Sprague-Dawley rats (n=10) instrumented concentration recording and received T11 drop...
Renal medullary endothelin B receptors (ET ) mediate sodium excretion and blood pressure (BP) control. Several animal models of hypertension including the Dahl salt sensitive (DS) rat on a high diet have impaired renal system. Our lab has recently reported that DS becomes hypertensive normal salt, high‐caloric diet. Thus we hypothesized ET function is dysfunctional in rats fed The diuretic natriuretic response to intramedullary infusion agonist sarafotoxin 6c (S6c) was determined either (14%...
Background: Human intestinal flora is affected by the exogenous microenvironment. This study aims to figure out effect of cigarette and alcohol drinking on gut microbiota in health adults.Methods: 170 subjects were enrolled divided into four groups including none smokers drinkers (group A), B), C), D). Fecal samples collected sequenced 16S rRNA analyze microbial composition KEGG predicted functional pathways. Short chain fatty acids (SCFAs) levels feces determined gas...
INTRODUCTION: A diet high in FODMAPs (HFM) induces symptoms patients with irritable bowel syndrome (IBS) and a low (LFM) improves up to 60% of IBS patients. Studies report increased colonic mast cell abundance activation subset However, the role cells pathophysiology related symptom-generation has not been well studied. METHODS: C57Bl/6 mice deficient W-sash c-kit mutant (KitW/W-v) were randomized HFM or regular chow (RC) daily for 2 weeks. Ex vivo epithelial barrier function was assessed...