A5100620929- Neuropeptides and Animal Physiology
- Gastrointestinal motility and disorders
- Nerve injury and regeneration
- Mesenchymal stem cell research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Gastroesophageal reflux and treatments
- Heart Rate Variability and Autonomic Control
- Tissue Engineering and Regenerative Medicine
- Healthcare professionals’ stress and burnout
- Retinal Diseases and Treatments
- Chinese history and philosophy
- Receptor Mechanisms and Signaling
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Translation Studies and Practices
- Traditional Chinese Medicine Studies
- Digital Media and Visual Art
- Neurogenesis and neuroplasticity mechanisms
- Phytochemical Studies and Bioactivities
- Ocular Surface and Contact Lens
- Human Health and Disease
- Phytochemical and Pharmacological Studies
- Vitamin K Research Studies
- Traditional Chinese Medicine Analysis
- Nursing education and management
Guangdong Provincial People's Hospital
2024-2025
Ningxia Medical University
2015-2024
Xiang Yang No.1 People's Hospital
2024
Hubei University of Medicine
2024
Second Affiliated Hospital of Guangzhou Medical University
2022-2024
Guangzhou Medical University
2022-2024
Xian Yang Central Hospital
2023
He Eye Hospital
2023
The First People’s Hospital of Lianyungang
2022
Bengbu Medical College
2022
Abstract Small cell lung cancer (SCLC) is characterized by a high relapse rate, drug tolerance, and limited treatment choices. Chimeric antigen receptor (CAR)-modified NK cells represent promising immunotherapeutic modality for treatment. However, their potential applications have not been explored in SCLC. Delta-like ligand 3 (DLL3) has reported to be overexpressed SCLC may rational target CAR immunotherapy. In this study, we developed DLL3-specific NK-92 the of A coculture DLL3+ lines with...
There are not enough nurses around the world, and there even fewer male nurses. It has been easy for men to become because of stereotypes about roles women in workplace, which lead prejudice discrimination. This study explored how self-esteem nursing students affects their professional identity an environment where social exist. also examined differences relevant variables different sociodemographic characteristics research subjects a Chinese context.By purposive snowball sampling, 464 were...
The important effects of variability some physiological/biological characteristics (such as LDL cholesterol, blood pressure) on cardiovascular outcomes have been elucidated, while the role insulin is undefined. To investigate associations long-term fasting during young adulthood before onset diabetes with subsequent in middle age. We included 3,983 CARDIA (Coronary Artery Risk Development Study Young Adults) participants aged 18 to 30 years at least three measurements. Intra-individual was...
Background:The application of chimeric antigen receptor (CAR) NK cells in solid tumors is hindered by lack tumor-specific targets and inefficient CAR-NK cell efficacy.Claudin-6 (CLDN6) has been reported to be overexpressed ovarian cancer may an attractive target for immunotherapy.However, the feasibility using anti-CLDN6 treat remains explored.Methods: CLDN6 expression primary human cancer, normal tissues lines were detected immunohistochemistry western blot.Two types third-generation CAR...
The aim of this study was to elucidate the preventive and therapeutic effects underlying mechanisms Huoxue Huatan Decoction (HXHT) on myocardial ischemia/reperfusion (I/R) injury in hyperlipidemic rats. An I/R model established Wistar After 4–8 weeks HXHT treatment, physical signs rats were observed. Lipid metabolism, enzyme spectrum, cardiac function, histomorphology, mitochondrial biosynthesis investigated by a biochemical method, ultrasonography, electron microscopy, pathological...
Abstract Peripheral nerve gaps often lead to interrupted innervation, manifesting as severe sensory and motor dysfunctions. The repairs of the injuries have not achieved satisfactory curative effects in clinic. transplantation bone marrow stromal cells (BMSCs)‐laden acellular xenografts (ANX) has been proven more effective than allografting. Besides, granulocyte colony‐stimulating factor (G‐CSF) can inhibit inflammation apoptosis, thus is conducive microenvironmental improvement axonal...
The distribution and activity of endomorphins (EMs), which are endogenous μ-opioid receptor (MOR) ligands in the gastrointestinal tract (GI), yet to be elucidated. current study aimed shed light on this topic. EM2 was expressed enteric neurons myenteric plexus mid-colon. Of EM2-immunoreactive (EM2-IR) neurons, 53 ± 4.6%, 26 4.5%, 2.8% 49 4.2% displayed immunopositive staining for choline acetyl transferase (ChAT), substance P (SP), vasoactive intestinal peptide (VIP) nitric oxide synthetase...
To investigate dentists' psychological status and influencing factors in Shaanxi Province during the COVID-19 epidemic assess their perceived wellness.The study was conducted among dentists from China. The basic information collected through network questionnaire star platform. Depression, Anxiety, Stress Scales (DASS-42) Perceived Wellness Survey (PWS) were used to subjects' wellness. Univariate linear regression analysis multivariate performed on of depression, anxiety, stress, t-test...
Animal care and use statement: The animal protocol was designed to minimize pain or discomfort the animals.The animals were acclimatized laboratory conditions (23 ℃, 12 h/12 h light/dark, 50% humidity, ad libitum access food water) for two weeks prior experimentation.All euthanized by barbiturate overdose (intravenous injection, 150 mg/kg pentobarbital sodium) tissue collection.
SUMMARY Although the importance of elevated circulating plasma catecholamines on cardiac structural and functional remodelling hypertension is well documented, it unclear whether catecholamine–b‐adrenoreceptor (bAR)–cAMP system can predict different cardiovascular events. A total 601 identified hypertensive patients with baseline follow‐up levels noradrenaline (NA) adrenaline (Adr), lymphocyte bAR density (B max ) intralymphocyte cAMP in peripheral blood (last examination 60 ± 26 months...
Peripheral nerve defects result in severe denervation presenting sensory and motor functional incapacitation. Currently, a satisfactory therapeutic treatment promoting the repair of injured nerves is not available. As shown our previous study, acellular xenografts (ANX) implanted with bone marrow stromal cells (BMSCs) replaced allografts promoted regeneration. Additionally, granulocyte-colony stimulating factor (G-CSF) has been proven to mobilize supplemental enhance vascularization niche....
Background . Traditional Chinese Medicine is extensively used in China and HuoxueAnshen Recipe (HAR) was formulated according to its method treating CHD accompanied with insomnia clinic. However, there are few studies related the effect of HAR on myocardial injury sleep disorders. Purpose To investigate effects deprivation‐ (SD‐) induced I/R injury. Methods Male Wistar rats receiving a daily gavage or vehicle were exposed SD intervention while control had normal sleep. Then all I/R. Hormone,...
Abstract This study was designed to explore the expression changes of P2Y 1 receptors in distal colonic myenteric layer rats. An opioid induced constipation(OIC) rat model generated by intraperitoneal (i.p) injection loperamide. At 7 days post-treatment, rats were assessed calculating fecal water content and gastrointestinal transit ratio. The immunofluorescence (IF)-based histochemical used observe distribution plexus. Western blotting (WB) performed evaluate proteins layer,...
Abstract Background: Acute myocardial infarction (AMI) is a common cause of mortality in intensive care unit (ICU) patients, which often accompanied by hemodynamic instability. We aimed to develop nomogram integrated parameters predict both short-term and long-term overall survival patients with AMI. Methods: 1606 AMI from the Medical Information Mart for Intensive Care III database were retrospectively enrolled, all whom underwent measurement within 24 h ICU admission. In primary cohort,...
Abstract The differentiation of bone marrow stromal cells (BMSCs) into Schwann‐like (SCLCs) has the potential to promote structural and functional restoration injured axons. However, optimal induction protocol its underlying mechanisms remain unclear. This study aimed compare effectiveness different protocols in promoting rat BMSCs SCLCs explore their mechanisms. were induced using two distinct methods: a composite factor approach (Protocol‐1) conditioned culture medium (Protocol‐2)....
The aim of the present study was to explore expression changes P2Y purinergic receptor 1 (P2Y1) in distal colonic submucosa opioid-induced constipation (OIC) rats and its association with occurrence OIC, an OIC rat model generated by intraperitoneal injection loperamide hydrochloride, a selective agonist µ-opioid receptors (MORs). At 7 days post-treatment, assessed analyzing stool scores calculating gastrointestinal (GI) transit ratio rats. distribution P2Y1-expressing neurons submucosal...
Abstract Background To observe morphologic and functional changes in meibomian glands pediatric patients with without lower eyelid epiblepharon. Methods In this prospective observation study, 55 eyes of 60 controls were included. The following tests performed: margin abnormality by slit-lamp examination, measurement noninvasive keratographic break-up time (NIKBUT), grading absence gland (meibography score) assessed noncontact meibography, (thinning, dilatation distortion), tear production...