A5103156745- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare and Venom Research
- Anesthesia and Pain Management
- Cerebral Palsy and Movement Disorders
- Nerve Injury and Rehabilitation
- Intensive Care Unit Cognitive Disorders
- Botulinum Toxin and Related Neurological Disorders
- Music Therapy and Health
- Anesthesia and Sedative Agents
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Inflammasome and immune disorders
- Nausea and vomiting management
- Neuroscience and Neuropharmacology Research
- Cardiac, Anesthesia and Surgical Outcomes
- RNA modifications and cancer
- S100 Proteins and Annexins
- Neurological Complications and Syndromes
Wenzhou Medical University
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Shanghai Children's Hospital
2018-2024
Shanghai Jiao Tong University
2018-2024
National Geological Archives of China
2024
China Geological Survey
2024
Zhejiang Provincial People's Hospital
2015-2023
Nanjing University of Chinese Medicine
2023
People’s Hospital of Wenshan Prefecture
2020
Wenzhou City People's Hospital
2018-2020
Objectives: To determine the occurrence rate, outcomes, and characteristics of severe sepsis in surgical intensive care units multiple medical centers within China to assess cost resource use China. Design Setting: Prospective, observational study unit patients at ten university hospitals six provinces Patients: All adult admissions studied from December 1, 2004, November 30, 2005. Interventions: None. Measurements Main Results: The criteria were based on American College Chest...
Astrocytes are critical in synapse development, and their dysfunction crucial developmental stages leads to serious neurodevelopmental diseases, including seizures epilepsy. Immune challenges not only affect brain but also promote seizure generation epileptogenesis, implying immune activation is one of the key factors linking epilepsy abnormal development. In this study, we report that activating astrocytes by systemic lipopolysaccharide (LPS) second postnatal week promotes excitatory...
Background: Although N 6 -methyladenosine (m A) plays a very important role in different biological processes, its function the brain has not been fully explored. Thus, we investigated roles of RNA demethylases Alkbh5/Fto cerebral ischemia-reperfusion injury. Methods: We used rat model and primary neuronal cell culture to study m A cortex ischemic penumbra after Alkbh5-shRNA Lv-Fto ( vitro) regulate expression their regulation Results: found that levels increased consecutive increase Alkbh5...
Cerebral ischemic stroke (IS) is still a difficult problem to be solved; energy metabolism failure one of the main factors causing mitochondrion dysfunction and oxidation stress damage within pathogenesis cerebral ischemia, which produces considerable reactive oxygen species (ROS) opens blood-brain barrier. Dichloroacetic acid (DCA) can inhibit pyruvate dehydrogenase kinase (PDK). Moreover, DCA has been indicated with capability increasing mitochondrial uptake promoting glucose in course...
Previous studies have demonstrated that cardiomyocyte apoptosis, ferroptosis, and inflammation participate in the progress of sepsis-induced cardiomyopathy (SIC). Although Islet cell autoantigen 69 (ICA69) is an imperative molecule could regulate immune response numerous illnesses, its function cardiovascular disease, particularly SIC, still elusive. We confirmed LPS significantly enhanced expression ICA69 wild-type (WT) mice, macrophages, cardiomyocytes. The knockout...
ABSTRACT The NACHT, LRR, and PYD domains‐containing protein 3 (NLRP3) inflammasome plays an important role in a variety of diseases. However, the NLRP3 human intervertebral disc (IVD) degeneration remains unknown. In present study, we assessed expression levels its downstream targets caspase‐1 IL‐1β 45 degenerate seven nondegenerate IVD samples. correlation between scores NLRP3, caspase‐1, were also analyzed. mRNA three molecules (NLRP3, IL‐1β) higher IVDs group than controls (nondegenerate...
Neuroinflammation mediated by microglial pyroptosis is an important pathogenic mechanism of septic encephalopathy (SAE). It has been reported that TRIM45 associated with tumours and inflammatory diseases. However, the role in SAE relationship between are unknown. In this study, we found played regulating molecular mechanism.SAE was induced intraperitoneal injection LPS WT AAV-shTRIM45 mice. BV2 cells were treated LPS/ATP vitro. Cognitive function assessed Morris water maze. Nissl staining...
Inflammatory and immune responses, as well melatonin secretion, are affected by circadian regulation. Abnormal rhythm of release has been reported to be associated with the later stages sepsis; however, its role in early sepsis is unclear. We studied 11 septic non-septic patients our intensive care unit (ICU). Peripheral blood was drawn at 4-h intervals on first day, beginning 2:00 p.m., over a total period 24 h. Plasma levels melatonin, tumor necrosis factor α (TNF-α) interleukin 6 (IL-6)...
To evaluate whether ferroptosis is involved in hyperoxic acute lung injury (HALI) and its mechanisms through the HALI model.HE staining was used to assess pathology after establishment of neonatal rat model. ELISA detect ROS, GPX4, GSH expression. Prussian blue Western Blot were iron deposition expression ferroptosis-related proteins, respectively.The group showed pathological changes with larger fewer alveoli thicker alveolar septa HE staining. detected significant tissue group. GSH, GSS,...
The treatment options for sepsis-associated encephalopathy caused by systemic inflammation are still not sufficient. Protein kinase C interaction protein 1 (PICK1) has attracted much attention because of its important physiological functions in many tissues. However, role remains elusive. Our study results revealed that the expression levels PICK1 mice with lipopolysaccharide-induced were significantly changed, but deficiency led to excessive activation microglia and Toll-like receptor...
Electroacupuncture (EA) is commonly used to treat cerebrovascular diseases. This study aimed clarify the mechanisms of action treatments cerebral ischemic stroke from perspective gut microecology. We a mouse model and cell cultures investigate effects EA on intestinal microflora in mice models middle artery occlusion (MCAO) underlying antioxidant activities metabolites. Fecal microbiota transplantation (FMT) was validate roles microbiota. Metabolomic analysis performed characterize metabolic...
Abstract Introduction Fungal infection is increasingly common in critical illness with severe sepsis, but the influence of invasive fungal (IFI) on sepsis not well understood. The aim this study was to investigate impact that IFI has outcomes critically ill surgical patients China by means matched cohort analysis; we also evaluated epidemiologic characteristics population. Methods Records for all admissions 10 university hospital intensive care units (ICUs) from December 2004 November 2005...
Sepsis is a systemic inflammatory reaction caused by infection. Multiple organ failure ultimately leads to high morbidity and mortality. Unfortunately, therapies against these responses have been unsuccessful due the insufficient underlying pathophysiological evidence. Protein interacting with C-kinase 1 (PICK1) has received considerable attention because of its important physiological functions in many tissues. However, role sepsis-induced acute lung injury (ALI) unclear. In this study, we...
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine that ubiquitously distributed in the central and peripheral nervous systems. Moreover, its phosphorylated (P-CaMKII) involved memory, mood, pain regulation anterior cingulate cortex (ACC). Electroacupuncture (EA) traditional Chinese therapeutic technique can effectively treat chronic inflammatory pain. However, CaMKII-GluA1 role EA analgesia ACC remains unclear. This study investigated of P-CaMKII...