A5068589036- Psoriasis: Treatment and Pathogenesis
- RNA Research and Splicing
- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Traumatic Brain Injury and Neurovascular Disturbances
- Dermatology and Skin Diseases
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Cutaneous lymphoproliferative disorders research
- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Antibiotics Pharmacokinetics and Efficacy
- Ultrasound and Hyperthermia Applications
- Circular RNAs in diseases
- Immune Response and Inflammation
- Traumatic Brain Injury Research
- RNA Interference and Gene Delivery
- Musculoskeletal synovial abnormalities and treatments
- Heat Transfer Mechanisms
- Ultrasound Imaging and Elastography
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
Wenzhou Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
Shenyang Pharmaceutical University
2025
Peking University
2019-2024
Hunan Cancer Hospital
2020-2024
Central South University
2020-2024
Peking University First Hospital
2019-2024
Beijing Sport University
2024
Chengde Medical University
2022-2023
First Hospital of Qinhuangdao
2022-2023
Abstract Psoriasis is the most common skin disease in adults. Current experimental and clinical evidences suggested infiltrating immune cells could target local thus induce psoriatic phenotype. However, recent studies indicated existence of a potential feedback signaling loop from resident to cells. Here, we deconstructed full-thickness human skins both healthy donors patients with psoriasis vulgaris at single cell transcriptional level, further built neural-network classifier evaluate...
Background: Although peptides are widely used in the clinical treatment of various diseases due to their strong biological activity, they usually require frequent injections owing poor vivo half-life. Therefore, there is a need for sustained peptide formulations. Methods: In this study, liraglutide (Lir) and biocompatible multivesicular liposomes (MVLs) were utilized as model drug sustained-release carriers, respectively. The release rate Lir-MVLs was controlled by changing ratio SPC DEPC...
Abstract Background The clinicopathological and survival profiles across primary sites in acral melanoma (AM) are still controversial unclear. Methods This is a multi-center retrospective study. Clinicopathological data of AM patients diagnosed between 1 January 2000 31 December 2017 from 6 large tertiary hospitals China were extracted. Chi square tests used to compare basic characteristics sole, palm nail bed. Melanoma-specific (MSS) differences based on compared by log-rank multivariate...
This study designs to investigate the role and potential mechanism of lncNRA HOTTIP in OS progression vitro vivo. HOTTIP, PTBP1, KHSRP expression levels were tested through qRT-PCR western blot tissues or cell lines. Cell proliferation was examined via CCK-8 colony formation. cycle apoptosis analyzed flow cytometry analysis. The invasive migratory abilities cells evaluated by transwell wound-healing assays. localization determined subcellular fractionation assay. RNA pull down...
To the Editor: Psoriasis is a common chronic immune-mediated systemic inflammatory disease[1] characterized by irritating skin erythema, reduced quality of life, and associated diseases including cardiovascular disease, diabetes, metabolic syndrome. In 2017, 0.5% China's population was diagnosed with psoriasis.[2] improve overall diagnosis treatment level psoriasis in China, National Clinical Research Center for Skin Immune Disease launched national collaborative project called Standardized...
Ulceration is regarded as an adverse prognostic factor and used together with tumour thickness to subcategorize patients cutaneous melanoma. However, the impact of ulceration in acral melanoma (AM) controversial.To assess AM variability across different Breslow thicknesses clinical stages.A multicentre retrospective study diagnosed between January 2000 December 2017. Differences melanoma-specific survival (MSS) without were assessed using multivariable Cox proportional hazards model log-rank...
BackgroundEvidence for the prognostic importance of tumor thickness in acral melanoma (AM) patients is limited.ObjectiveThe objective study was to determine impact Breslow AM.MethodsThis multicenter enrolled diagnosed with localized AM between January 1, 2000 and December 31, 2017. Melanoma-specific survival (MSS) different strata (T1-T4: ≤1, >1-2, >2-4, >4 mm, respectively) estimated by Kaplan-Meier method. Comparisons were performed log-rank test multivariable Cox regression.ResultsA total...
Melanoma is a human skin malignant tumor with high invasion and poor prognosis. The limited understanding of genomic alterations in melanomas China impedes the diagnosis therapeutic strategy selection. We conducted comprehensive profiling from 39 primary metastatic formalin-fixed paraffin-embedded (FFPE) samples 27 patients based on an NGS panel 223 genes. No significant difference gene was found between metastasis melanomas. status germline mutation, CNV, somatic mutation our cohort quite...
Emerging evidence has revealed the importance of long non-coding RNAs (lncRNAs) in carcinogenesis. The aim this work was to investigate roles lncRNA growth arrest specific 5 (GAS5) osteosarcoma (OS) progression.Real-time quantitative polymerase chain reaction (RT-qPCR) performed explore GAS5, microRNA-663a (miR-663a), and ras homolog family member B (RHOB) expression levels OS tissues cells. Moreover, cell counting kit-8 assay, wound-healing transwell invasion assay were conducted biological...
Psoriasis is a common disease in dermatology, but its etiology and pathogenesis have not been fully elucidated. In recent years, researchers found that HOX transcript antisense RNA (HOTAIR) plays an important role biological processes as long-chain noncoding (lncRNA). The goal of this study was to investigate the association between HOTAIR polymorphisms psoriasis Chinese Han population by screening key candidate single-nucleotide polymorphism (SNPs) sites HOTAIR. A total 269 patients...
Under the condition of weakly cemented soft rock in Western China, surrounding deformation gob-side entry is obvious, especially under influence fault, and problem control becomes increasingly prominent. To solve this issue, paper firstly studied obtained evolution law ground pressure appearance fault area, then put forward concept area entry, a targeted relief + increase preload passive reinforcement parallel to roadway strengthening scheme, carried out field applications. The results show...
To facilitate unobtrusive and continuous sleep monitoring promote intelligent quality assessment, we present a dataset that includes multiple nights of ballistocardiogram (BCG) data collected using piezoelectric film sensors from 32 subjects in their regular environments. Besides, the referenced heart rate respiratory are also recorded by reference to validate accuracy cardiac components extracted BCG signals. The serves as foundation for research on vital sign based signals, offering...
Helicobacter pylori (H. pylori) infection is a well-known risk factor for gastric cancer. Toll-like receptor 9 (TLR9) plays an important role in many cancers and immunity to H. infection. Thus, the present study aimed evaluate influence of on TLR9 explore its roles cancer.TLR9 expression MKN45 cells, which were cocultured with or without DNA, was detected using quantitative reverse transcription-polymerase chain reaction Western blot assays. Then, knocked down through RNA interference...
Abstract Background The aim of this study was to evaluate the influence patient body mass index (BMI) and estimated creatinine clearance (CrCl) on serum vancomycin concentrations define a possible optimal dosage regimen in overweight patients based data obtained during therapeutic drug monitoring. Methods This retrospective used collected from January 2017 2019. Adult ( n = 204) received treatment at dose 1000 mg every 12 h underwent Data included disease category, sex, age, height, weight,...
Psoriasis is a complex, chronic autoimmune disorder predominantly affecting the skin. Accumulating evidence underscores critical role of localized cellular inflammation in development and persistence psoriatic skin lesions, involving cell types such as keratinocytes, mesenchymal cells, Schwann cells. However, underlying mechanisms remain largely unexplored. Long non-coding RNAs (lncRNAs), known to regulate gene expression across various processes, have been particularly implicated immune...
Surgical resection and reconstruction for low-grade bone sarcoma in the metaphysis of distal femur remain challenging. We hypothesized that 3D printing osteotomy guide plate could assist to accurately resect tumor lesion save joint function.From January 2017 August 2019, five patients diagnosed with were treated hemicortical using plate. Autologous graft was inactivated a high-temperature water bath re-implanted situ fixed screw. Patients followed up from 17 33 months. The Musculoskeletal...
Recent advances in the management of bone tumors have led to a significant increase survival rates patients with malignant tumors. Thus, limb salvage surgery has gained importance for preserving function However, presents unique difficulties terms biomechanics and obtaining soft-tissue cover, such as when ankle is involved primary tumor. We report case chondrosarcoma distal tibia treated wide en bloc resection arthrodesis reconstruction defect using distraction osteogenesis, which offers an...
Background . Abnormal apoptosis of keratinocytes is one the pathological changes psoriasis. Caspases (CASPs) are central engines apoptosis. Studies to date have shown that some SNPs alter expression related genes and lead in disease risk. However, no studies investigated associations between gene polymorphisms risk psoriasis Han population northeast China. Therefore, we conducted a case-control study explore this question northeastern Methods 540 patients with PsV 612 healthy age-...
Ixekizumab is a monoclonal antibody targeting interleukin-17A that has shown significant improvement in alleviating psoriasis. However, data sparse on the efficacy of ixekizumab psoriasis patients China. To investigate Chinese patients. Patients with moderate-to-severe were retrospectively investigated from April 2020 to October 2020. A total 16 treated 80 mg every two weeks after 160-mg loading dose. Efficacy was assessed using Psoriasis Activity and Severity Index (PASI), static...