A5100455142- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Lipid metabolism and biosynthesis
- Bone fractures and treatments
- Liver Disease Diagnosis and Treatment
- Climate Change and Health Impacts
- Cancer, Hypoxia, and Metabolism
- Cholesterol and Lipid Metabolism
- Fungal Infections and Studies
- Thermoregulation and physiological responses
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
- RNA Research and Splicing
- Nonmelanoma Skin Cancer Studies
- Antifungal resistance and susceptibility
- Wound Healing and Treatments
- Diagnosis and Treatment of Venous Diseases
- Cutaneous lymphoproliferative disorders research
- Cancer-related gene regulation
- Dermatology and Skin Diseases
- Hepatitis B Virus Studies
- Body Composition Measurement Techniques
- Dermatologic Treatments and Research
- Lung Cancer Treatments and Mutations
First Affiliated Hospital of Nanchang University
2023-2025
Nanchang University
2023-2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2025
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2025
Chengdu University of Traditional Chinese Medicine
2025
Jena University Hospital
2025
The First People's Hospital of Xiaoshan District, Hangzhou
2019-2024
Wenzhou Medical University
2018-2024
Peking University First Hospital
2008-2024
Peking University
2009-2024
Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin mucous membrane injury, which may cause acute chronic dermatitis, secondary infection aggravation of underlying diseases. This is a consensus Chinese experts on protective measures advice hand-cleaning- medical-glove-related hand protection, mask- goggles-related face UV-related eye nasal oral mucosa outer ear, hair protection. It necessary strictly follow standards wearing equipment specification...
Abstract c-Myc is regarded as a transcription factor, but the basis for its function remains unclear. Here, we define long noncoding RNA (lncRNA)/protein complex that mediates transcriptional activation by in breast cancer cells. Among 388 target genes human MCF-7 cells, found their promoters could be occupied oncoprotein HBXIP. We confirmed HBXIP expression correlated with of cyclin A, eIF4E, and LDHA. RNAi-mediated silencing abolished c-Myc–mediated upregulation these genes....
Objective Clinical sepsis-associated biomarkers were utilized in a cecal ligation and puncture (CLP) septic mouse model to provide reference for investigating pathophysiological mechanisms evaluating novel therapeutic interventions sepsis. Methods Sepsis mice was induced by CLP, clinical evaluated (survival rate, blood physiological biochemical indices, cytokines, hepatorenal function parameters, coagulation). Results The mortality rate >70%. body temperature, pressure, heart decreased...
Abstract Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin distinguished by the presence clonal malignant cells. The heterogeneity cells and complex tumor microenvironment remain poorly characterized. With single-cell RNA analysis bulk whole-exome sequencing on 19 skin lesions from 15 CTCL patients, we decipher intra-tumor inter-lesion diversity patients propose multi-step evolution model. We further establish subtyping scheme based molecular features their...
There is an urgent need to address the effective diagnosis of multiple diseases across various medical institutions while ensuring privacy data in IoT environments. This requires model have ability zero-shot generalization, which can not be satisfied by existing models. To this issue, we propose a two-stage for image diagnosis, based on decoupling and decorrelating. An adversarial architecture built using gradient reversal discriminator improve model's robustness. further mixed correlation...
In order to construct a more universal model for understanding the genetic requirements bacterial AsIII oxidation, an in silico examination of available sequences GenBank was assessed and revealed 21 conserved 5-71 kb arsenic islands within phylogenetically diverse genomes. The included oxidase structural genes aioBA, ars operons (e.g., arsRCB) which code resistance, pho, pst, phn known be part classical phosphate stress response that encode functions associated with regulating acquiring...
Abstract Background The clinicopathological and survival profiles across primary sites in acral melanoma (AM) are still controversial unclear. Methods This is a multi-center retrospective study. Clinicopathological data of AM patients diagnosed between 1 January 2000 31 December 2017 from 6 large tertiary hospitals China were extracted. Chi square tests used to compare basic characteristics sole, palm nail bed. Melanoma-specific (MSS) differences based on compared by log-rank multivariate...
Objectives: Dendrobium officinale polysaccharide (DOP) is the main active ingredient in a valuable traditional Chinese medicine, which exerts several pharmacological activities including hepatoprotection and hypoglycemic effects. However, effects of DOP on obesity-associated insulin resistance (IR) lipid metabolism remain unknown. This study aimed to investigate role IR abnormal obese mice. Methods: models were established using 3T3-L1 adipocytes, C2C12 myocytes, primary cultured hepatocytes...
The gut microbiota is a dynamic and highly diverse microbial ecosystem that affects many aspects of the host’s physiology. An improved understanding could lead to better strategies for diagnosis therapy cryptococcal meningitis (CM), but impact Cryptococcus infection anti-fungal treatment on has rarely been studied. We characterized diversity composition in CM patients at healthy controls (HCs) using metagenomic sequencing determined effects drugs. found had distinct bacterial fungal...
Abstract Comprehensive reference genomes are needed for the classification and functional characterization of human skin microbiota. Here, we established microbiome genome (HSMG) protein (HSMP) catalogs by integrating 739 newly sequenced 2,520 published samples, along with two microbial catalogs. The HSMG includes 3547 prokaryotic species, which 1556 (43.87%) unidentified, HSMP contains 39,283,339 nonredundant proteins, 64.8% poorly characterized. Using as a reference, identified distinct...
Introduction Studies have revealed that Tai Chi can enhance cognitive functions among patients with mild impairment (MCI). However, the precise mechanisms underlying this improvement remain elusive. Methods Consequently, we conducted a study involving 54 elderly inpatients MCI residing in combined medical and care facility Chengdu, who were randomly divided into three groups: control group engaging daily living activities, performed exercises addition to walking undertook activities as...
Background: Sepsis is a life-threatening condition characterized by organ dysfunction due to an imbalanced immune response infection, with high mortality. Ferroptosis, iron-dependent cell death process, and cellular senescence, which exacerbates inflammation, have recently been implicated in sepsis pathophysiology. Methods: Weighted gene co-expression network analysis (WGCNA) was used identify ferroptosis- senescence-related modules sepsis. Differentially expressed genes (DEGs) were analyzed...
Cryptococcus neoformans causes cryptococcal meningitis, which is frequent in patients with HIV/AIDS, especially less-developed countries. The incidence of meningitis close to 1 million each year globally.
Background Immune cells play an integral role in the development and progression of non-alcoholic fatty liver disease (NAFLD). This study was to identify immune-cell-related biomarkers for diagnosis treatment NAFLD. Methods findings First, we introduced human transcriptome data from GEO database (GSE48452 GSE126848) performed a weighted gene co-expression network analysis (WGCNA) screen out modules related immune cell infiltration differentially expressed genes (ICR-DEGs) associated with...
Long non-coding RNA (lncRNA) H19 is a hot spot in tumor development, progression and metastasis. This study assessed the association between genetic polymorphisms susceptibility of lung cancer.The case-control was conducted to evaluate four selected single nucleotide (rs217727, rs2107425, rs2735469 rs17658052) gene risk cancer. There were 556 female never smoking cancer patients 395 cancer-free controls. Unconditional logistic regression analysis used analyze associations SNPs risks by...