A5101397713- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Bioactive Compounds and Antitumor Agents
- Hippo pathway signaling and YAP/TAZ
- Cutaneous lymphoproliferative disorders research
- Protein Tyrosine Phosphatases
- Lymphoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Bone Metabolism and Diseases
- PI3K/AKT/mTOR signaling in cancer
- Scientific Research and Studies
- Signaling Pathways in Disease
- Psoriasis: Treatment and Pathogenesis
- Hedgehog Signaling Pathway Studies
- Sulfur-Based Synthesis Techniques
- Cancer and Skin Lesions
- Alkaloids: synthesis and pharmacology
- Cholesterol and Lipid Metabolism
- Lipid metabolism and biosynthesis
- Hypertrophic osteoarthropathy and related conditions
- Hair Growth and Disorders
- Circular RNAs in diseases
- Biochemical Analysis and Sensing Techniques
- Skin Protection and Aging
Peking University First Hospital
2006-2025
Peking University
2006-2025
National Clinical Research Center for Digestive Diseases
2021-2024
Chengdu Medical College
2012-2024
National Medical Products Administration
2022
Qingdao Eighth People's Hospital
2020
Chengdu Institute of Biology
2012
Abstract Cutaneous T cell lymphoma (CTCL) represents a heterogeneous group of non-Hodgkin distinguished by the presence clonal malignant cells. The heterogeneity cells and complex tumor microenvironment remain poorly characterized. With single-cell RNA analysis bulk whole-exome sequencing on 19 skin lesions from 15 CTCL patients, we decipher intra-tumor inter-lesion diversity patients propose multi-step evolution model. We further establish subtyping scheme based molecular features their...
Abstract Background: Topical finasteride is a novel treatment for men with an androgenetic alopecia (AGA). This study aimed to evaluate the efficacy and safety of topical spray solution in Chinese AGA. Methods: randomized, double-blind, placebo-controlled, phase III trial enrolled 270 individuals AGA from 16 sites across China between December 2021 March 2023. The participants were randomized at ratio 2:1 receive either or placebo once daily 24 weeks. primary endpoint was change baseline...
Objective: To obtain potential skin whitening agents from traditional Chinese herbs, we tested changes of melanin content in melanocyte cell lines after treatment with extracts 90 herbs. Methods: Mouse were used. Depigmentation activity the herb first screened Mel-Ab cells, and then re-evaluated melan-a cells co-culture SP-1 cells. Melanin viability two indications for evaluation. Tyrosinase expression synthesis related enzymes treated also tested. Results: Nine proved to have depigmentation...
Calophyline A (1), a novel unprecedented rearranged monoterpenoid indole alkaloid, along with new natural product N-methyl aspidodasycarpine (2) and six known analogues, was isolated from the trunk barks of Winchia calophylla. The structure compound 1 elucidated on basis spectroscopic data then confirmed by single-crystal X-ray crystallographic analysis. hypothetical biogenetic pathway for proposed. All compounds were evaluated their in vitro cytotoxicity against small panel human cancer cell lines.
Toll-like receptor 3 (TLR3) is a sensor of endogenous cell necrosis during the process acute inflammation. Interleukin (IL)-1 antagonist (IL-1Ra) an anti-inflammatory cytokine and can negatively regulate pathogenesis However, whether how activation TLR3 IL-1Ra expression has not been clarified. Here, we show that poly(I:C) induces in primarily cultured human fibroblast-like synoviocytes other types cells. Induction by was dependent on TLR3, but independent melanoma...
Taurine upregulated gene 1 (TUG1) has been recognized as a novel oncogenic gene. The current study was established to explore the function and regulatory mechanism of TUG1 in hepatocellular carcinoma (HCC).Quantitative real-time polymerase chain reaction (qRT-PCR) used detect expression TUG1, miR-29c-3p, COL1A1 tissues cell lines. MTT assay, wound-healing transwell assay were utilized for detection viability, migration invasion, respectively. interactions between miR-29c-3p TUG1/COL1A1...
Abstract Abnormal activation of fibroblasts plays a crucial role in keloid development. However, the mechanism fibroblast remains to be determined. YAP/TAZ are key molecules Hippo signalling pathway that promote cell proliferation and inhibit apoptosis. Here, we show have higher levels mRNA proteins on primary culture. Targeted knockdown endogenous YAP or TAZ significantly inhibited proliferation, reduced migration, induced apoptosis down‐regulated collagen1a1 production by fibroblasts....
Abstract Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, undergo large-cell transformation (LCT) in late stage, manifesting aggressive behavior, resistance to treatments, and poor prognosis, but mechanisms involved remain unclear. To identify molecular driver LCT, we collected tumor samples from 133 MF patients performed whole-transcriptome sequencing on 49 advanced-stage patients, followed by integrated copy number inference genomic hybridization. Tumors with LCT...
BD750, a novel JAK3/STAT5 inhibitor, can inhibit T cell proliferation. This study aims to evaluate whether BD750 induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune encephalitis (EAE) mice. Following treatment, lipopolysaccharide (LPS)-induced maturation of DCs, allogeneic proliferation, Th1 Th17 functional differentiation, STAT5 AKT activation were determined. The effect tolDC loaded with antigen peptide on the development severity EAE splenic responses...
Immunosuppressive drugs have shown great promise in treating autoimmune diseases recent years. A series of novel oxazole derivatives were screened for their immunosuppressive activity. PO-322 [1H-indole-2,3-dione 3-(1,3-benzoxazol-2-ylhydrazone)] was identified as the most effective these compounds. Here, we investigated mechanism(s) underlying inhibition T-cell proliferation vitro by PO-322, well its effects on delayed-type hypersensitivity (DTH) response and imiquimod-induced dermatitis...
Benzothiazole derivatives are known for various biological activities, and their potency in cancer therapy have received considerable attention recent years. However, the poor water solubility of most benzothiazole has limited clinical application. We developed BD926, a novel water-soluble derivative showed here that it could inhibit proliferation induce apoptosis human Ramos B-lymphoma cells. further BD926 triggered through both mitochondria endoplasmic reticulum pathways. Moreover, caused...
Background: Benzothiazole and its derivatives have been extensive studied due to their versatile biological properties pharmaceutical applications. We recently found that the BMP326 (1-(1,3-benzothiazol-2-yl)-3-(2-methoxyphenyl)-1H-pyrazol-5-ol), a novel benzothiazole derivative, anti-inflammatory in lipopolysaccharide(LPS)-induced RAW264.7 macrophages there were no relevant reports previously. Methods Results: Treatment with BMP326(5, 10 20 μM) can significantly inhibit nitric oxide...
An otherwise healthy 30-year-old man visited the dermatology department for an enlarging bluish-grey nodule on his scalp 6 months.The had developed a skin-colored lump which gradually grown up from two small alopecic plaques since birth (Figure 1A).Dermoscopy showed homogenous bluewhite pigmentation surrounded by white dots and brown-red Figure 1.(A) Bluish-grey atrophic plaque collared hair, with infiltrated firm (arrow).(B) Dermoscopy blue-white pigmentation, dots, area.(C D)...
Abstract: The lipedematous scalp (LS) is characterized by a thickened because of the increased thickness subcutaneous fat layer. When soft and boggy associated with shortened hairs hair loss, it referred to as alopecia (LA). We report case areata LS, which may be misdiagnosed LA. However, histopathologic features showed layer bulb inflammation. Hair regrowth was appreciable after treatment topical steroids, minoxidil, oral compound glycyrrhizin, vitamin D. This aims show that LS coexist,...
Abstract Background: Benzothiazole and its derivatives have been extensive studied due to their versatile biological properties pharmaceutical applications. We recently found that the BMP326 (1-(1,3-benzothiazol-2-yl)-3-(2-methoxyphenyl)-1H-pyrazol-5-ol), a novel benzothiazole derivative, anti-inflammatory in lipopolysaccharide(LPS)-induced RAW264.7 macrophages there were no relevant reports previously. Methods Results: Treatment with BMP326(5, 10 20 μM) can significantly inhibit nitric...