A5100691206- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Wound Healing and Treatments
- Orthopaedic implants and arthroplasty
- Nanoplatforms for cancer theranostics
- biodegradable polymer synthesis and properties
- Dental materials and restorations
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Biodiesel Production and Applications
- Biological and pharmacological studies of plants
- GaN-based semiconductor devices and materials
- Nerve injury and regeneration
- Industrial Technology and Control Systems
- Polymer composites and self-healing
- Advanced biosensing and bioanalysis techniques
- Dental Implant Techniques and Outcomes
- Metal and Thin Film Mechanics
- Semiconductor materials and devices
- Biosensors and Analytical Detection
- Postharvest Quality and Shelf Life Management
- Immune Response and Inflammation
- Edible Oils Quality and Analysis
- Tannin, Tannase and Anticancer Activities
- Planarian Biology and Electrostimulation
Kunming Medical University
2018-2024
Shenyang Agricultural University
2011-2024
Guangdong Province Women and Children Hospital
2024
Southwest Minzu University
2024
Shanghai East Hospital
2023
Hohhot Minzu College
2022
Henan Agricultural University
2021
Case Western Reserve University
2020
Cornell University
2020
Hebei University of Technology
2020
Abstract Pathogenic infection inevitably provokes chronic inflammation and stalls the normal orchestrated course of wound‐healing cascades. However, current antibacterial therapies focus on inherent bactericidal functions biomaterials. To take full advantage microenvironment (IME) peculiarities, an IME‐activated nanocatalytic membrane consisting electrospun poly (lactic‐co‐glycolic acid) (PLGA) scaffolds, MXene/Ag 2 S bio‐heterojunctions (MX/AS bio‐HJs), lactate oxidase (LOx) for cutaneous...
Wound healing is a highly orchestrated process involving variety of cells, including immune cells. Developing immunomodulatory biomaterials for regenerative engineering applications, such as bone regeneration, an appealing strategy. Herein, inspired by the effects gastrodin (a bioactive component in traditional Chinese herbal medicine), series new gastrodin-comprising biodegradable polyurethane (gastrodin-PU) and nano-hydroxyapatite (n-HA) (gastrodin-PU/n-HA) composites were developed. RAW...
The development of functional materials for osteoporosis is ultimately required bone remodeling. However, grafts were accompanied by increasing pro-inflammatory cytokines that impaired formation. In this work, nano-hydroxyapatite (n-HA)/resveratrol (Res)/chitosan (CS) composite microspheres designed to create a beneficial microenvironment and help improve the osteogenesis local sustained release Res. Study in vitro confirmed feasibility n-HA/Res/CS controlled Res release. Notably, had...
To improve the mechanical properties of bone tissue and achieve desired regeneration for orthopedic surgery, newly designed hydroxyapatite/polyurethane (HA/PU) porous scaffolds were developed via in situ polymerization. The results showed that molecular modification PU soft segments by glyceride castor oil (GCO) can increase scaffold compressive strength 48% elastic modulus 96%. When nano-HA (n-HA) particles incorporated into GCO-PU matrix, further increased 49 74%, from 2.91 to 4.34 MPa 95...
As a chronic metabolic disease, diabetes mellitus (DM) creates hyperglycemic micromilieu around implants, resulting inthe high complication and failure rate of implantation because mitochondrial dysfunction in hyperglycemia. To address the daunting issue, authors innovatively devised developed mitochondria-targeted orthopedic implants consisted nutrient element coatings polyetheretherketone (PEEK). Dual elements, modality ZnO Sr(OH)2 , are assembled onto sulfonated PEEK surface...
Abstract Infection and malignant tumors are the most common diseases in people's daily life, which seriously threaten human health. Because of frequent extensive administration antibiotics chemodrugs, prevalence multidrug‐resistant bacteria tumor cells makes conventional therapies less effective even invalid. To overcome repugnant dilemma, herein authors devise develop a hollow Cu 2− X S nano‐homojunction (nano‐HJ) platform for eradication both upon tissue‐penetrable near‐infrared (NIR)...
Abstract For quick disinfection treatment, phototherapy, including photothermal therapy and photodynamic therapy, has emerged as a promising alternative to conventional methods. However, the bactericidal effect of which only works upon light, is short‐lived. The remaining bacteria in situ may repopulate when irradiation light withdrawn. To address this refractory concern, an antibacterial fibrous membrane consisting electrospun poly (polycaprolactone) scaffolds polydopamine (pDA) coated...
Peripheral nerve regeneration and functional recovery remain a major clinical challenge. Nerve guidance conduit (NGC) that can regulate biological behavior of Schwann cells (SCs) facilitate axonal through microenvironmental remodeling is beneficial for recovery. Gastrodin, main constituent Chinese traditional herbal medicine, has been known to display several pharmacological properties, especially antioxidative, anti‐inflammatory regeneration. Herein, polyurethane (PU) NGCs modified by...
Antibacterial chemodynamic therapy (aCDT) has captured considerable attention in the treatment of pathogen-induced infections due to its potential inactivate bacteria through germicidal reactive oxygen species (ROS). However, lifespan ROS generated by CDT is too short achieve efficacy complete sterilization; thus, residual inevitably reproduce and cause super-infections. To address this concern, we devise an innovative bimetal, metal-organic framework (BMOF) domino micro-reactor (BMOF-DMR),...
Abstract Clinically, bacteria‐induced contagion and insufficient osseointegrative property inevitably elicit the failure of orthopedic implants. Herein, a heterostructured coating consisting simvastatin (SIM)‐laden metal–organic frameworks polydopamine nanolayers is created on porous bioinert polyetheretherketone implant. The significantly promotes cytocompatibility osteogenic differentiation through multimodal osteogenicity mechanisms zinc ion (Zn 2+ ) therapy, SIM drug surface...
Vascular grafts must avoid negative inflammatory responses and thrombogenesis to prohibit fibrotic deposition immediately upon implantation promote the regeneration of small diameter blood vessels (<6 mm inner diameter). Here, polyurethane (PU) elastomers incorporating anti-coagulative anti-inflammatory Gastrodin were fabricated. The films had inter-connected pores with porosities equal or greater than 86% pore sizes ranging from 250 400 μm. Incorporation into PU resulted in desirable...
Currently MI repair approaches always exhibit low efficiency and do not match the clinical requirements. To provide an advanced engineering platform, injectable hydrogel was developed to release OSM continuously localized in lesion.
The bone tissue engineering primarily focuses on three-dimensional co-culture systems, which physical and biological properties resemble the cell matrix of actual tissues. complex dialogue between bone-forming endothelial cells (ECs) in a tissue-engineered construct will directly regulate angiogenesis regeneration. purpose this study was to investigate whether osteogenic angiogenic derived by mesenchymal stem (MSCs) could affect activities new formation.Mesenchymal were dually induced...
Solving the issue of infection associated with implanted bone substitutes is one modern challenges biomedical engineering field. The purpose this study was to develop a novel porous scaffold sufficient antibacterial activity for repair or regeneration. Porous nanohydroxyapatite/polyurethane (n-HA/PU) composite scaffolds containing different amounts silver phosphate particles were prepared through in situ foaming method. Subsequently, their physicochemical properties, abilities, and...
Toll-like receptor 3 (TLR3) is a sensor of endogenous cell necrosis during the process acute inflammation. Interleukin (IL)-1 antagonist (IL-1Ra) an anti-inflammatory cytokine and can negatively regulate pathogenesis However, whether how activation TLR3 IL-1Ra expression has not been clarified. Here, we show that poly(I:C) induces in primarily cultured human fibroblast-like synoviocytes other types cells. Induction by was dependent on TLR3, but independent melanoma...
The n-HA/CS microspheres exhibit good properties while supporting cell growth, thus acting as a promising injectable matrix for bone tissue engineering.
The extracellular matrix provides cells with a support structure and an attachment site in actual substrate. Its biochemical surface properties play important role have significant impact on cell attachment, proliferation, migration, differentiation, gene expression. Leveraging the hydrophilicity neuroprotective of gastrodin, gastrodin/polyurethane (PU) elastomer was developed utilizing situ polymerization salt-leaching methods. results showed that gastrodin/PU film had good flexibility...
Against the backdrop of Ministry Education's promotion new agricultural science construction and interdisciplinary integration, a comprehensive chemistry experiment to enhance practical skills students in preparing biomass functional materials detecting pesticide residues was designed. Natural loofah utilized as precursor synthesizing nitrogen-doped magnetic porous carbon materials, which were then applied solid-phase extraction (MSPE) technique. Subsequently, high performance liquid...