A5021210237- Dental materials and restorations
- Dental Erosion and Treatment
- Bone Tissue Engineering Materials
- Bone and Dental Protein Studies
- Oral microbiology and periodontitis research
- Nanoplatforms for cancer theranostics
- Dental Implant Techniques and Outcomes
- Dendrimers and Hyperbranched Polymers
- Endodontics and Root Canal Treatments
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- MXene and MAX Phase Materials
- Periodontal Regeneration and Treatments
- Dental Research and COVID-19
- Antimicrobial Peptides and Activities
- Legionella and Acanthamoeba research
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Bacterial Infections and Vaccines
- Oral and gingival health research
- Dental Trauma and Treatments
- Orthopedic Infections and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Forensic Toxicology and Drug Analysis
- HIV/AIDS oral health manifestations
Sichuan University
2016-2025
State Key Laboratory of Oral Diseases
2016-2025
Stomatology Hospital
2017-2025
University of Maryland, Baltimore
2016-2022
National Clinical Research
2022
Chengdu University
2015-2019
University of Dental Medicine
2015
Dalian Medical University
2012-2013
Chongqing Medical University
2012-2013
Second Affiliated Hospital of Chongqing Medical University
2012-2013
Abstract Pathogenic infection inevitably provokes chronic inflammation and stalls the normal orchestrated course of wound‐healing cascades. However, current antibacterial therapies focus on inherent bactericidal functions biomaterials. To take full advantage microenvironment (IME) peculiarities, an IME‐activated nanocatalytic membrane consisting electrospun poly (lactic‐co‐glycolic acid) (PLGA) scaffolds, MXene/Ag 2 S bio‐heterojunctions (MX/AS bio‐HJs), lactate oxidase (LOx) for cutaneous...
Abstract For quick disinfection treatment, phototherapy, including photothermal therapy and photodynamic therapy, has emerged as a promising alternative to conventional methods. However, the bactericidal effect of which only works upon light, is short‐lived. The remaining bacteria in situ may repopulate when irradiation light withdrawn. To address this refractory concern, an antibacterial fibrous membrane consisting electrospun poly (polycaprolactone) scaffolds polydopamine (pDA) coated...
The integrity of collagen matrix structure is a prerequisite for effectively inducing biomimetic remineralization. Repeated low pH stimulation activates metalloproteinases (MMPs) in dental caries. Activated MMPs cause the breakdown fibrils. Collagen stabilization major obstacle to clinical application remineralization templates. Here, galardin-loaded poly(amido amine) (PAMAM)-NGV (PAMAM-NGV@galardin, PNG) constructed induce and dentin simultaneously, order combat early caries dentin. PAMAM...
Phototherapy, such as photothermal therapy (PTT) and photodynamic (PDT) has been a powerful strategy to combat bacterial infection. However, the compact cell membranes of pathogenic bacteria, especially drug-resistant significantly diminish efficiency heat conduction impede entrance reactive oxygen species (ROS) into cells, resulting in unsatisfactory sterilization. Enlightened by membrane feature competent herein MXene/CaO
Abstract Chronic infectious bone destruction diseases, such as periodontitis, pose a significant global health challenge. Repairing the loss caused by these chronic infections remains challenging. In addition to pathogen removal, regulating host immunity is imperative. The retention of neutrophil extracellular traps (NETs) in niches found be barrier inflammation resolution. However, whether ruining existing NETs within local lesions can contribute resolve and repair understudied. Herein,...
Abstract Dynamic therapy utilizes reactive oxygen species (ROS) to antibacterial and enhance the innate immune system treat bacterial infections. If ROS levels are too low, elimination of pathogens enhancement immunity cannot be achieved. However, excess accumulation may impact intracellular glutathione (GSH) levels, hindering T cell maturation establishment memory. Herein, a multifunctional nanofiber membrane is designed, consisting polymer scaffold, MXene/CeO 2 bio‐heterojunctions (MX@Ce...
The remineralization of demineralized dentin with biomimetic templates is great interest in the fields material science and stomatology. Amine‐terminated PAMAM dendrimer (PAMAM‐NH 2 ), which possesses a highly ordered architecture many calcium coordination sites, may be desirable template for inducing remineralization. In this study, effect third generation PAMAM‐NH (G3‐PAMAM‐NH ) on investigated. Demineralized samples are treated G3‐PAMAM‐NH solution (1 mg · mL −1 then immersed artificial...
Poly(amidoamine) (PAMAM) dendrimers, known as artificial proteins, have unique and well-defined molecular size structure. It has previously been used to mimic protein-crystal interaction during biomineralization. In this study, generation 4.5 (4.5G) PAMAM with carboxylic acid (PAMAM-COOH) was synthesized utilized remineralize the surface of etched enamel in vitro. Using confocal laser scanning microscopy, Fourier transform infrared spectroscopy, X-ray diffraction analysis electron microscopy...
Dentin phosphoprotein (DPP) plays an extremely important role in the biomineralization of human tooth. The repetitive nucleotide sequence aspartate-serine-serine (DSS) is fundamental unit within DPP, and peptides containing 8 repeats DSS (8DSS) have been shown to possess ability induce remineralization demineralized enamel. In this work, we coated 8DSS peptide on completely dentin evaluate effect coating remineralization. Human samples were with 37% phosphoric acid for 2 min, then (1 mg...
Abstract Tooth enamel is prone to be attacked by injurious factors, leading a de/remineralization imbalance. To repair demineralized and prevent pulp inflammation caused biofilm accumulation, measures are needed promote remineralization inhibit bacterial adhesion on the tooth surface. An innovative material, poly (aspartic acid)-polyethylene glycol (PASP-PEG), was designed synthesized construct mineralizing anti-adhesive surface that could applied enamel. A cytotoxicity assay revealed low of...
Photodynamic therapy (PDT) acts as a powerful weapon against infectious diseases for its enormous antimicrobial activity that quickly elicits storms of reactive oxygen species (ROS). Nevertheless, redundant ROS during treatment inevitably bring detriments in revascularization. To address this dilemma, an innovative P-N bio-heterojunction (bio-HJ) material consisting p-type copper sulfide (p-CuS), n-type bismuth (n-Bi2 S3 ), and lactate oxidase (LOx) effective recalcitrant wounds by promoting...