A5056959473- Oral microbiology and periodontitis research
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic and phenotypic traits in livestock
- Dental materials and restorations
- Genomics and Phylogenetic Studies
- Dental Health and Care Utilization
- Bone and Dental Protein Studies
- Reproductive biology and impacts on aquatic species
- Fish Biology and Ecology Studies
- Endodontics and Root Canal Treatments
- Genetic diversity and population structure
- Infective Endocarditis Diagnosis and Management
- Fish Ecology and Management Studies
- Nanoplatforms for cancer theranostics
- Animal Genetics and Reproduction
- Geoscience and Mining Technology
- Geomechanics and Mining Engineering
- Identification and Quantification in Food
- Dental Radiography and Imaging
- Corneal Surgery and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Wound Healing and Treatments
- Oral Health Pathology and Treatment
Chinese Academy of Fishery Sciences
2016-2025
Sichuan University
2016-2025
State Key Laboratory of Oral Diseases
2016-2025
Stomatology Hospital
2025
Qingdao National Laboratory for Marine Science and Technology
2016-2023
Laoshan Laboratory
2023
Ministry of Agriculture and Rural Affairs
2018-2023
China Academy of Building Research
2023
Marine Biology Institute of Shandong Province
2021-2022
University of Pennsylvania
2019
Abstract Chinese tongue sole is a marine fish with ZW sex determination. Genome sequencing suggested that the Z-linked dmrt1 putative male determination gene, but direct genetic evidence still lacking. Here we show TALEN of efficiently induced mutations this gene. The ZZ mutant developed ovary-like testis, and spermatogenesis was disrupted. female-related genes foxl2 cyp19a1a were significantly increased in gonad mutant. Conversely, male-related Sox9a Amh decreased. deficient grew much...
Abstract Pathogenic infection inevitably provokes chronic inflammation and stalls the normal orchestrated course of wound‐healing cascades. However, current antibacterial therapies focus on inherent bactericidal functions biomaterials. To take full advantage microenvironment (IME) peculiarities, an IME‐activated nanocatalytic membrane consisting electrospun poly (lactic‐co‐glycolic acid) (PLGA) scaffolds, MXene/Ag 2 S bio‐heterojunctions (MX/AS bio‐HJs), lactate oxidase (LOx) for cutaneous...
Abstract For quick disinfection treatment, phototherapy, including photothermal therapy and photodynamic therapy, has emerged as a promising alternative to conventional methods. However, the bactericidal effect of which only works upon light, is short‐lived. The remaining bacteria in situ may repopulate when irradiation light withdrawn. To address this refractory concern, an antibacterial fibrous membrane consisting electrospun poly (polycaprolactone) scaffolds polydopamine (pDA) coated...
The integrity of collagen matrix structure is a prerequisite for effectively inducing biomimetic remineralization. Repeated low pH stimulation activates metalloproteinases (MMPs) in dental caries. Activated MMPs cause the breakdown fibrils. Collagen stabilization major obstacle to clinical application remineralization templates. Here, galardin-loaded poly(amido amine) (PAMAM)-NGV (PAMAM-NGV@galardin, PNG) constructed induce and dentin simultaneously, order combat early caries dentin. PAMAM...
Peptides containing 8 repeats of aspartate-serine-serine (8DSS) have been shown to promote the nucleation calcium phosphate from solution into human enamel. Here we tested ability 8DSS remineralization demineralized enamel in an vitro model artificial early caries. Initial caries lesions were created bovine blocks, which then subjected 12 d pH cycling presence 25 µM 8DSS, 1 g/L NaF (positive control) or buffer alone (negative control). Absorption was verified by X-ray photoelectron...
The cariogenic pathogen Streptococcus mutans effectively utilizes dietary sucrose for the synthesis of exopolysaccharide, which act as a scaffold its biofilm, thus contributing to pathogenicity, environmental stress tolerance, and antimicrobial resistance. two-component system VicRK S. regulates group virulence genes that are associated with biofilm matrix synthesis. Knockout vicX affects formation, oxidative transformation mutans. However, little is known regarding vicX-modulated structural...
To investigate oral health status in the residents of Sichuan Province, southwest China, a cross-sectional study was performed using latest Oral Health Survey Basic Methods recommended by World Organization. A multistage stratified random cluster-sampling method used to enroll participants from following three groups: children aged 3–5 years, adolescents 12 and people 65–74 years. In these groups, mean numbers teeth that were affected caries 3.28, 0.86 5.13, respectively, resulting...
Root canal calcification is considered a great challenge during root treatment. Although the application of ultrasonic instruments and dental operating microscope (DOM) has advantages, dealing with calcified canals still suffers risk failure because limited information about location, length, direction obliteration on periapical radiographs. In this work, cone-beam computed tomography- (CBCT-) aided method aimed at solving complicated in which conventional approaches could not work was...
Abstract Chronic infectious bone destruction diseases, such as periodontitis, pose a significant global health challenge. Repairing the loss caused by these chronic infections remains challenging. In addition to pathogen removal, regulating host immunity is imperative. The retention of neutrophil extracellular traps (NETs) in niches found be barrier inflammation resolution. However, whether ruining existing NETs within local lesions can contribute resolve and repair understudied. Herein,...
Abstract Dynamic therapy utilizes reactive oxygen species (ROS) to antibacterial and enhance the innate immune system treat bacterial infections. If ROS levels are too low, elimination of pathogens enhancement immunity cannot be achieved. However, excess accumulation may impact intracellular glutathione (GSH) levels, hindering T cell maturation establishment memory. Herein, a multifunctional nanofiber membrane is designed, consisting polymer scaffold, MXene/CeO 2 bio‐heterojunctions (MX@Ce...
Existing coal filling mining technologies face significant challenges of controlled surface subsidence, efficient utilization waste rock in mines, and a shortage adequate materials. This study introduces an innovative cut-and-fill method designed to strategically partition the goaf into cutting zones. In zone, situ materials are employed construct column supports adjacent thereby achieving subsidence. approach is integrated with long-wall operations implemented using advanced, comprehensive...
Introduction: Dental caries is a non-communicable disease caused by dysbiosis of dental biofilm. S. mutans considered the major pathogen. The orphan response regulator GcrR negatively regulates exopolysaccharides (EPSs) synthesis in mutans. We aimed to investigate effect on cariogenicity oral biofilms. A multispecies biofilm model was constructed, including mutans, sanguinis, and gordonii. Methods: morphology biofilms detected through scanning electron microscopy (SEM), structure observed...
Dental caries is a biofilm-dependent disease that largely relies on the ability of Streptococcus mutans to synthesize exopolysaccharides. Although rnc gene suggested be involved in virulence mechanisms many other bacteria, information regarding it S. very limited. Here, we demonstrated deletion or overexpression significantly positively regulated exopolysaccharide synthesis and further altered biofilm formation. Meanwhile, cariogenecity was decreased by specific pathogen-free (SPF) rat...
Abstract Background Edwardsiella tarda causes acute symptoms with ascites in Japanese flounder ( Paralichthys olivaceus ) and is a major problem for China’s aquaculture sector. Genomic selection (GS) has been widely adopted breeding industries because it shortens generation intervals results the of individuals that have great potential high accuracy. Based on an artificial challenge test re-sequenced data 1099 flounders, aims this study were to estimate genetic parameters resistance E....
In present study, a 10-month feeding trial was carried out to investigate effects of dietary Lactobacillus plantarum and Bacillus subtilis supplementation singly on growth performance, innate immune response, antioxidant capacity digestive enzyme activity olive flounder under commercial production environment. Two experimental groups fed basal diet with L. (5.0 × 107 CFU/g diet) B. (1.0 108 respectively, control group without probiotics supplement. At harvest, serum parameters, liver indices...
Abstract Complete skin reconstruction is a hierarchical, physiological assembly process involving healing of the epidermis, dermis, vasculature, nerves, and cutaneous appendages. To date, few works have reported complete regeneration, particularly lacking vascular structures hair follicles after full defects. In this study, hydrogel derived from secretion Andrias davidianus (SSAD) that features adhesiveness was used as bioactive scaffold to load micronized amnion (MA). The SSAD found promote...
Photodynamic therapy (PDT) acts as a powerful weapon against infectious diseases for its enormous antimicrobial activity that quickly elicits storms of reactive oxygen species (ROS). Nevertheless, redundant ROS during treatment inevitably bring detriments in revascularization. To address this dilemma, an innovative P-N bio-heterojunction (bio-HJ) material consisting p-type copper sulfide (p-CuS), n-type bismuth (n-Bi2 S3 ), and lactate oxidase (LOx) effective recalcitrant wounds by promoting...
The cariogenic pathogen Streptococcus mutans effectively utilizes dietary sucrose for the synthesis of exopolysaccharides (EPS), which act as a scaffold its biofilm and thus contribute to pathogenicity. Dextranase (Dex), is type glucanase, participates in degradation water-soluble glucan (WSG); however, structural features EPS regulated by dexAgene have received limited attention. Our recent studies reported novel protocols fractionate analyzed characteristics glucans from S biofilms. In...
The aim of the current study was to explore factors influencing dental caries among 3–5-year-old children in Sichuan Province and interrelationship between these using structural equation modelling (SEM). A cross-sectional conducted 2746 Province. Examination on all a questionnaire answered by children's caregiver. SEM alternative models were constructed interpret intricate relationships socio-economic status (SES), caregiver's oral health knowledge, attitudes, behaviours caries. results...
Single nucleotide polymorphism (SNP) arrays are a powerful genotyping tool used in genetic research and genomic breeding programs. Japanese flounder (Paralichthys olivaceus) is an economically-important aquaculture flatfish many countries. However, the lack of high-efficient tools has impeded programs for flounder. We developed 50K SNP array, "Yuxin No. 1," report its utility selection (GS) disease resistance to bacterial pathogens. screened more than 42.2 million SNPs from whole-genome...