A5063787759- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Aquaculture disease management and microbiota
- T-cell and B-cell Immunology
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Reproductive biology and impacts on aquatic species
- Molecular Biology Techniques and Applications
- Animal Genetics and Reproduction
- Wildlife Ecology and Conservation
- Lymphoma Diagnosis and Treatment
- Plant Virus Research Studies
- Genetic and phenotypic traits in livestock
- Sperm and Testicular Function
- Hepatitis B Virus Studies
- Chronic Lymphocytic Leukemia Research
- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- Animal Behavior and Reproduction
- RNA Interference and Gene Delivery
- Geological and Geophysical Studies
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Animal Virus Infections Studies
- Hippo pathway signaling and YAP/TAZ
- Identification and Quantification in Food
Beijing Normal University
2024-2025
Southwest Minzu University
2022-2024
Nanjing Medical University
2024
Chongqing Public Health Medical Center
2024
Luoyang Normal University
2023-2024
Shenzhen University
2024
Qingdao Agricultural University
2021-2024
Qinghai Tibetan Hospital
2023
Chengdu University of Traditional Chinese Medicine
2023
Chongqing Medical University
2012-2023
Songlin Chen and colleagues sequenced the whole genomes of a male (ZZ) female (ZW) Chinese half-smooth tongue sole, Cynoglossus semilaevis. Their analysis provides insights into structure evolution sex chromosomes adaptation to benthic lifestyle this flatfish. Genetic determination by W Z has developed independently in different groups organisms. To better understand plasticity sex-determination mechanisms, we sole (Cynoglossus semilaevis). In addition lifestyle, find that these fish are...
Abstract Chinese tongue sole is a marine fish with ZW sex determination. Genome sequencing suggested that the Z-linked dmrt1 putative male determination gene, but direct genetic evidence still lacking. Here we show TALEN of efficiently induced mutations this gene. The ZZ mutant developed ovary-like testis, and spermatogenesis was disrupted. female-related genes foxl2 cyp19a1a were significantly increased in gonad mutant. Conversely, male-related Sox9a Amh decreased. deficient grew much...
Crocodilians are diving reptiles that can hold their breath under water for long periods of time and crepuscular animals with excellent sensory abilities. They comprise a sister lineage birds have no sex chromosome. Here we report the genome sequence endangered Chinese alligator (Alligator sinensis) describe its unique features. The next-generation sequencing generated 314 Gb raw sequence, yielding size 2.3 Gb. A total 22 200 genes were predicted in Alligator sinensis using de novo,...
Summary. The expression of apoptosis‐related genes BCL2 , BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real‐time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia (ALL, n = 16), myeloid (AML, 27), chronic (CML, 12), mantle cell lymphoma (MCL, 19) lymphoid (CLL, 32). BAX were overexpressed in all patient groups. BCL2L1 underexpressed CLL CML, but not AML, ALL MCL. MCL1 levels significantly higher CD13 CD33‐positive ALL,...
Neural network architecture determines its functional output. However, the detailed mechanisms are not well characterized. In this study, we focused on neural architectures of male and hermaphrodite C. elegans association with sexually dimorphic behaviors. We applied graph theory computational neuroscience methods to systematically discern features these two networks. Our findings revealed that a small percentage sexual-specific neurons exerted dominance throughout entire net-work,...
Neural network architecture determines its functional output. However, the detailed mechanisms are not well characterized. In this study, we focused on neural architectures of male and hermaphrodite C. elegans association with sexually dimorphic behaviors. We applied graph theory computational neuroscience methods to systematically discern features these two networks. Our findings revealed that a small percentage sexual-specific neurons exerted dominance throughout entire net-work,...
Genetic variation plays a significant role in maintaining the evolutionary potential of species. Comparing patterns adaptive and neutral diversity extant populations is useful for understanding local adaptations In this study, we determined fine-scale genetic structure 6 giant panda (Ailuropoda melanoleuca) using mtDNA DNA fingerprints, then overlaid variations functional Aime-MHC class II genes (DRA, DRB3, DQA1, DQA2, DQB1, DQB2) on framework. We found that: (1) analysis fingerprint-based...
Abstract Figla is a germ-cell-specific transcription factor associated with ovary development and differentiation. In vertebrates, one transcriptional form of commonly found. However, besides the common this gene (named Figla_tv1 ), new Figla_tv2 ) was identified in half-smooth tongue sole ( Cynoglossus semilaevis ). The full-length cDNA 1057 bp long 591-bp open reading frame encoding predicted 196 amino acid protein, while encoded 125 protein. expression various tissues detected by qRT-PCR....
Abstract Gsdf is a key gene for testicular differentiation in teleost. However, little known about the function of Chinese tongue sole ( Cynoglossus semilaevis ). In this study, we obtained full-length CS - ), and functional characterization revealed its potential participation during germ cell testes. transcription was predominantly detected gonads, while levels testes were significantly higher than those ovaries. During different developmental stages male mRNA level upregulated at 86 dph,...
Wnt4 gene plays a role in developmental processes mammals. However, little is known regarding its function teleosts. We cloned and characterized the full-length half-smooth tongue sole (Cynoglossus semilaevis) wnt4a (CS-wnt4a). CS-wnt4a cDNA was 1746 bp length encoding 353aa. expression level highest testis gradually increased developing gonads until 1 year of age. In situ hybridization revealed that stage II oocytes sperm adult ovary testis, respectively. significantly up-regulated after...
The round-tailed paradise fish (Macropodus ocellatus) is important to the local ecosystem and economy. Other species in genus Macropodus are undergoing population declines, indicating that M. ocellatus might also be declining. Therefore, status of ocellatus, related standing-water stability sustainable utilization fishery resources, requires attention. In this study, we assessed spatial pattern genetic structure 10 localities from China. Sequencing Cytb (1135 bp) D-loop (668 yielded 26...
Abstract Background The biodiversity crisis and increasing impact of wildlife disease on animal human health provides impetus for studying immune genes in wildlife. Despite the recent boom genomes species, are poorly annotated nonmodel species owing to their high level polymorphism complex genomic organisation. Our research over past decade a half Tasmanian devils koalas highlights importance genomics accurate annotations investigate Given this, we have increasingly been asked minimum levels...
Summary. Mantle cell lymphoma (MCL) is a non‐Hodgkin's of B‐cell lineage. The blastoid variant MCL, characterized by high mitotic rate, clinically more aggressive than common MCL. We used the cDNA array technology to examine gene expression profiles both and data was analysed regression analysis, principal component analysis naive Bayes' classifier. Eight genes were identified as differentially deregulated between two groups. Oncogenes CMYC , BCL2 PIM1 upregulated frequently in This implied...
The Major Histocompatibility Complex (MHC) is a hyper-polymorphic genomic region, which forms part of the vertebrate adaptive immune system and crucial for intra- extra-cellular pathogen recognition (MHC-I MHC-IIA/B, respectively). Although recent advancements in high-throughput sequencing methods sparked research on MHC non-model species, evolutionary history gene structure still poorly understood birds. Here, to explore macroevolutionary patterns avian architecture, we retrieved contigs...
Evaluating patterns of genetic variation is important to identify conservation units (i.e., evolutionarily significant [ESUs], management [MUs], and adaptive [AUs]) in endangered species. While neutral markers could be used infer population history, their application the estimation limited. The capacity adapt various environments vital for long-term survival Hence, analysis loci, such as major histocompatibility complex (MHC) genes, critical genetics studies. Here, we investigated 4...
Invertebrates greatly support the growth, development, and reproduction of insectivorous birds. However, influence human activity (e.g., pesticide use, deforestation, urbanization) inevitably leads to a decrease in global arthropods. The diversity variation invertebrate diet food composition birds, especially species living rapidly changing environments, such as Tibetan Plateau. little is known seasonal response environmental changes. Here, we characterized pre- post-breeding black-necked crane (