A5016309719- Hepatitis B Virus Studies
- Hepatitis C virus research
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- Cancer Cells and Metastasis
- Genetic diversity and population structure
- Hepatocellular Carcinoma Treatment and Prognosis
- Identification and Quantification in Food
- Invertebrate Taxonomy and Ecology
- Metabolomics and Mass Spectrometry Studies
- Polar Research and Ecology
- Fish Biology and Ecology Studies
- Microbial Community Ecology and Physiology
- Aquaculture disease management and microbiota
- Study of Mite Species
- Ecology and Conservation Studies
- Molecular Biology Techniques and Applications
- Evolution and Genetic Dynamics
- Viral-associated cancers and disorders
- Fern and Epiphyte Biology
- Single-cell and spatial transcriptomics
- Speech and dialogue systems
- Actinomycetales infections and treatment
Nanjing Agricultural University
2024
Berry Oncology (China)
2020-2024
Yantai University
2023-2024
Nanjing Forestry University
2019-2023
Chengdu University of Technology
2023
State Forestry and Grassland Administration
2023
Yangzhou University
2022
Dalian Medical University
2016-2019
Liver cirrhosis (LC) is the highest risk factor for hepatocellular carcinoma (HCC) development worldwide. The efficacy of guideline-recommended surveillance methods patients with LC remains unpromising.
The a posteriori speech presence probability (SPP) is the fundamental component of noise power spectral density (PSD) estimation, which can contribute to enhancement and recognition systems. Most existing SPP estimators estimate accurately from background noise. Nevertheless, numerous challenges persist, including difficulty estimating non-stationary with statistics-based methods high latency associated deep learning-based approaches. This paper presents an improved estimation approach based...
Abstract Purpose: Intratumoral hepatitis B virus (HBV) integrations and mutations are related to hepatocellular carcinoma (HCC) progression. Circulating cell-free DNA (cfDNA) has shown itself as a powerful noninvasive biomarker for cancer. However, the HBV integration mutation landscape on cfDNA remains unclear. Experimental Design: A cSMART (Circulating Single-Molecule Amplification Resequencing Technology)-based method (SIM) was developed simultaneously investigate landscapes with...
The round-tailed paradise fish (Macropodus ocellatus) is important to the local ecosystem and economy. Other species in genus Macropodus are undergoing population declines, indicating that M. ocellatus might also be declining. Therefore, status of ocellatus, related standing-water stability sustainable utilization fishery resources, requires attention. In this study, we assessed spatial pattern genetic structure 10 localities from China. Sequencing Cytb (1135 bp) D-loop (668 yielded 26...
The liquid biopsy is being integrated into cancer diagnostics and surveillance. However, critical questions still remain, such as how to precisely evaluate mutation burden interpret the corresponding clinical implications. Herein, we evaluated role of peripheral blood cell‐free DNA (cfDNA) in characterizing dynamic alterations 48 driver genes from cervical patients. We performed targeted deep sequencing on 93 plasma cfDNA 57 patients this developed an algorithm, allele fraction deviation...
Food fraud is widespread in the aquatic food market, hence fast and non-destructive methods of identification fish flesh are needed. In this study, multispectral imaging (MSI) was used to screen slices from 20 edible species commonly found sea around Yantai, China, by combining based on mitochondrial COI gene. We that nCDA images transformed MSI data showed significant differences splices species. then employed eight models compare their prediction performances hold-out method with 70%...
Motivation: DNA methylation is an important epigenetic modification that has essential role in gene regulation, cell differentiation and cancer development. Bisulfite sequencing a widely used technique to obtain genome-wide profiles, one of the key tasks analyzing bisulfite data detect differentially methylated regions (DMRs) among samples under different treatment conditions. Although numerous tools have been proposed single CpG site (DMC) between samples, methods for direct DMR detection,...
Abstract Background Breast cancer stem cells (BCSCs) are considered responsible for relapse and drug resistance. Understanding the identity of BCSCs may open new avenues in breast therapy. Although several discoveries have been made on BCSC characterization, factors critical to origination largely unclear. This study aimed determine whether genomic mutations contribute acquisition stem‐like phenotype investigate genetic transcriptional features BCSCs. Methods We detected potential...
A new protocol has been developed for vinyl sulfide synthesis promoted by an alkoxy base under metal-free conditions. In this reaction, aryl and alkenyl sulfonium triflates with diverse functionalities are converted into sulfides excellent reactivity. This transformation features mild safe reaction conditions that avoid catalyst, transition metal, high-pressure gas, high temperature without compromising efficiency.
Cell-free DNA (cfDNA) is emerging as a potential biomarker for the detection of ovarian cancer (OC). Recently, we reported method based upon cfDNA whole-genome sequencing data including nucleosome distribution (nucleosome footprinting NF), terminal signature sequence (motif), fragmentation (fragment), and copy number variation (CNV).In present study, explored whether multiomics early screening technology in can be applied cancer.Fifty-nine patients with OC 100 healthy controls were included...
Abstract Background Exploring the association of diet and indoor outdoor environments on gut microbiome red-crowned cranes. We investigated profile 24 fecal samples collected from nine cranes day 1 to 35. Differences in composition were compared across environments. Results A total 2,883 operational taxonomic units (OTUs) detected, with 438 species-specific OTUs 106 common microbiomes four groups. The abundance Dietzia Clostridium XI increased significantly when initially fed live mealworms....
The relationship between CpG content and DNA methylation has attracted considerable interest in recent years. Direct or indirect methods have been developed to investigate their regulatory functions based on various hypotheses, large cohort studies, meta-analyses. However, all of these analyses were performed at units blocks and, thus, the influence finer genome structure neglected. Herein, we present a novel algorithm base-pair resolution systematically contents methylation. By introducing...
The complete mitochondrial genome of Lumbricus rubellus was analyzed by next-generation sequencing. mitogenome 15,464 bp in length, comprising 13 protein-coding genes (PCGs), 22 transfer RNAs, 2 ribosomal and a non-coding region. phylogenetic analysis PCGs within the class Oligochaeta suggested that L. placed as sister to terrestris same genus. results obtained here can contribute earthworms.
Abstract Introduction Targeted therapies are based on specific gene alterations. Various specimen types have been used to determine alterations, however, no systemic comparisons yet made. Herein, we assessed alterations in selected cancer‐associated genes across varying sample sites lung cancer patients. Materials and Methods deep sequencing for 48 tumor‐related was applied 153 samples from 55 patients obtained six sources: Formalin‐fixed paraffin‐embedded (FFPE) tumor tissues, pleural...
Abstract Investigation of spontaneous mutations by next-generation sequencing technology has attracted extensive attention lately due to the fundamental roles in evolution and pathological processes. However, these studies only focused on accumulated through many generations during long-term (possibly be years of) culturing, but not freshly generated that occur at very low frequencies. In this study, we established a molecularly barcoded deep strategy detect abundant genomes bacteria cell...
The complete mitogenome of a lorikeet, Trichoglossus rubritorquis (Psittaciformes, Loriidae), was determined first in the genus Trichoglossus. assembled 17,915 bp and composed 13 protein-coding genes, 22 tRNAs, two rRNAs control regions. Nucleotide composition T. 30.20% A, 33.30% C, 14.04% G, 22.46% T, with an A + T bias 52.66%. ML tree based on genes indicated that, Melopsittacus undulatus family Psittacidae closest related species to rubritorquis. This result suggested that lorikeets might...
The first complete mitogenome of Hong Kong paradise fish (Macropodus hongkongensis) was determined in this study. assembled is 16,494 bp and consisted 13 protein-coding genes, 22 tRNAs, 2 rRNAs, a control region. Nucleotide composition the 30.6% A, 24.8% C, 14.8% G, 29.8% T, with an A + T bias 60.4%. maximum-likelihood tree based on genes showed that M. erythropterus closest related species to hongkongensis.