Yanhang Gao
A5101779345- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug-Induced Hepatotoxicity and Protection
- Alcohol Consumption and Health Effects
- Cancer Genomics and Diagnostics
- Liver Diseases and Immunity
- HIV/AIDS drug development and treatment
- interferon and immune responses
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Plant-derived Lignans Synthesis and Bioactivity
- Oral and gingival health research
- Pneumocystis jirovecii pneumonia detection and treatment
- Drug Transport and Resistance Mechanisms
- Antifungal resistance and susceptibility
- Substance Abuse Treatment and Outcomes
- Heart Failure Treatment and Management
- IgG4-Related and Inflammatory Diseases
- Parathyroid Disorders and Treatments
- Pancreatic and Hepatic Oncology Research
First Hospital of Jilin University
2012-2024
Jilin University
2014-2024
Liaoning Cancer Hospital & Institute
2024
Dalian University of Technology
2024
National Institute of Diabetes and Digestive and Kidney Diseases
2023
ProQuest (United States)
2023
Background The interleukin-28B gene (IL28B) locus has been associated with host resistance to hepatitis C virus (HCV) infection and response PEG-IFN/RBV treatment in western populations. This study was determine whether this variant is also spontaneous clearance of HCV infection, IL-28B protein production Chinese patients. Methods We genotyped IL28B genetic variations (rs12980275, rs8103142, rs8099917 rs12979860) by pyrosequencing DNA samples from cohorts consisting 529 subjects persistent...
Liver cirrhosis (LC) is the highest risk factor for hepatocellular carcinoma (HCC) development worldwide. The efficacy of guideline-recommended surveillance methods patients with LC remains unpromising.
The diagnosis of hepatocellular carcinoma (HCC) often experiences latency, ultimately leading to unfavorable patient outcomes due delayed therapeutic interventions. Our study is designed develop and validate a model that employs triple-phase computerized tomography (CT)-based deep learning radiomics clinical variables for early warning HCC in patients with cirrhosis.
Definitions and descriptions of acute-on-chronic liver failure (ACLF) vary between Western Eastern types, alcoholism hepatitis B virus (HBV) are, respectively, the main etiologies. To determine whether there are unified diagnostic criteria common treatment programs for different etiologies ACLF, a multicenter prospective cohort with same inclusion disease indicators as those used in European Consortium Acute-on-Chronic Liver Failure Cirrhosis Study is urgently needed Asia, where prevalence...
Purpose Acute-on-chronic liver failure (ACLF) is a clinical syndrome with high short-term mortality, unclear mechanism and controversial diagnosis criteria. The Chinese Acute-on-Chronic Liver Failure (CATCH-LIFE) study has been conducted in China to fill the gaps. In first phase (the CATCH-LIFE investigation cohort), 2600 patients were continuously recruited from 14 national nationwide centres 12 different provinces of 2015–2016, series important results obtained. To validate preliminary...
Background and Aims: Acute-on-chronic liver failure (ACLF) is a highly dynamic syndrome. The objective of this study was to delineate the clinical course patients with HBV-ACLF develop model estimate temporal evolution disease severity. Methods: We enrolled eligible from 2 large, multicenter prospective cohorts. ACLF grade, organ failures, outcomes were assessed at multiple time points (days 1/4/7/14/21/28). Probabilities for transitions between these states death within 28 days calculated...
Hepatitis B virus (HBV) reactivation is a serious condition and has been extensively described in chemotherapeutic immunosuppressive population. However, little known about HBV immunocompetent patients with chronic hepatitis (CHB). In this study, we evaluated the prevalence clinical significance of CHB acute exacerbations. Patients were screened from two prospective multicenter observational cohorts (CATCH-LIFE cohort). A total 1,020 previous antiviral treatment history included to assess...
Abstract Background & Aims Current guidelines on the management of bacterascites are limited. This multicentre, retrospective study investigated clinical features and outcomes cirrhosis patients with bacterascites. Methods Two series were evaluated. The first included 418 ascites‐positive cultures at 11 hospitals during 2012‐2018. Clinical characteristics recorded. second 208 sterile ascites from a prospective cohort (NCT02457637). cirrhotic or without investigated. Results In series,...
Acute-on-chronic liver failure (ACLF) patients are susceptible to invasive fungal infections. We evaluated the prognosis and antifungal options in ACLF with pulmonary aspergillosis (IPA).ACLF IPA from 15 hospitals were retrospectively screened 2011 2018, 383 without lung infections included a prospective cohort (NCT02457637). Demographic, laboratory, clinical data, 28-day outcomes documented two cohorts.ACLF probable (n = 145) had greater mortality (33.6% vs. 15.7%, p < 0.001) than those...
Background and Objective: An increase in the international normalized ratio (INR) is associated with increased mortality patients cirrhosis other chronic liver diseases, while little known about quantitative relationship. This study aimed to investigate relationship between INR short-term prognosis among hospitalized or advanced fibrosis evaluate role of as a risk factor for transplant (LT)-free these patients. Patients Methods: prospectively analyzed multicenter cohorts established by...
The relationship between anemia and the outcome of patients with cirrhosis is not completely clear. Therefore, we performed this large-scale epidemiological study to investigate prevalence severity in acute decompensation or liver injury how impacts short-term long-term outcomes.
Acute decompensation (AD) of cirrhosis is associated with high short-term mortality, mainly due to the development acute-on-chronic liver failure (ACLF). Thus, there a need for biomarkers early and accurate identification AD patients risk ACLF mortality. Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) released from activated innate immune cells correlated various inflammatory processes.
This study investigated multidrug-resistant (MDR) pathogens and antibiotic strategies of culture-positive spontaneous ascitic infection (SAI) in patients with acute decompensated cirrhosis.We retrospectively analyzed 432 cirrhotic SAI from 11 teaching hospitals China (January 2012 to May 2018). A Cox proportional hazards model analysis was conducted identify independent predictors 28-day mortality.A total 455 strains were isolated culture samples. Gram-negative bacteria (GNB), gram-positive...
Importance: Hepatic encephalopathy is a severe complication, and its contribution to clinical adverse outcomes in patients with acute-on-chronic liver diseases from the East unclear. Objective: We aimed investigate impact of hepatic on characteristics prospective multicenter cohorts diseases. Design: conducted cohort study two cohorts. Setting: China. Participants: Acute-on-chronic disease various etiologies. Exposure: The diagnosis severity were assessed using West Haven scale. Main Outcome...
Background: Patients with cirrhosis have an increased risk of short-term mortality, however, few studies quantify the association between neutrophil-to-lymphocyte ratio (NLR) and 90-day transplant-free mortality in cirrhotic patients. Methods: We prospectively analyzed 3,970 patients chronic liver diseases from two multicenter cohorts China (January 2015 to December 2016 July 2018 January 2019). Restricted cubic splines (RCS) were used analyze relation NLR all-causes cirrhosis. Results: A...
Background and aims: Hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) is a complicated syndrome with extremely high short-term mortality. Whether plasma exchange (PE) improves HBV-ACLF outcomes remains controversial. Here, PE-based non-bioartificial support system (NB-ALSS) effects on patient were investigated. Materials methods: patients from Chinese Acute-on-chronic Liver Failure (CATCH-LIFE) cohort receiving standard medical therapy (SMT) alone or NB-ALSS in addition...
To evaluate the inhibitory effect of vitamin D3 analogue calcipotriol (Cal) on fibrosis pancreatic stellate cells (PSCs) induced by TGF-β1 and rationality Cal use in alcoholic chronic pancreatitis (ACP). Double-labeling immunofluorescence was used for identification VDR+PSCs pancreas healthy controls (HC) ACP patients. Van Gieson staining examination collagen fibers. RT-qPCR Western Blot determining mRNAs proteins VDR, COL1A1 or vitro PSCs. ELISA LC-MS/MS detection serum 25(OH)D3. The PSC...