A5078464222- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Muscle Physiology and Disorders
- Nanoplatforms for cancer theranostics
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Liver Disease and Transplantation
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Immune cells in cancer
- HIV Research and Treatment
- Immunotherapy and Immune Responses
- Advancements in Battery Materials
- interferon and immune responses
- Mitochondrial Function and Pathology
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Aortic Disease and Treatment Approaches
- HIV/AIDS drug development and treatment
- Extracellular vesicles in disease
- Anesthesia and Neurotoxicity Research
- Medical Imaging Techniques and Applications
- Lipid metabolism and biosynthesis
Huadong Hospital
2021-2025
Fudan University
2017-2025
Qingdao University
2011-2025
Affiliated Hospital of Qingdao University
2011-2025
Guangzhou Medical University
2018-2024
Nanjing Second Hospital
2024
Hanzhong People's Hospital
2024
Guangzhou Eighth People's Hospital
2008-2023
Huazhong Agricultural University
2023
Inner Mongolia Medical University
2023
Abstract Induction of tumor cell death is the therapeutic goal for most anticancer drugs. Yet, a mode drug-induced death, known as immunogenic (ICD), can propagate antitumoral immunity to augment efficacy. Currently, molecular hallmark ICD features release damage-associated patterns (DAMPs) by dying cancer cells. Here, we show that gemcitabine, standard chemotherapy various solid tumors, triggers immunostimualtory DAMP (e.g., calreticulin, HSP70, and HMGB1); however, unable induce ICD....
Abstract Activating cGAS‐STING pathway has great potential to achieve effective antitumor immunotherapy. However, mutant p53 (mutp53), a commonly observed genetic alteration in over 50% of human cancer, will impede the therapeutic performance pathway. Herein, multifunctional ZIF‐8@MnO 2 nanoparticles are constructed degrade mutp53 and facilitate The synthesized can release Zn 2+ Mn cancer cells induce oxidative stress cytoplasmic leakage fragmented mitochondrial double‐stranded DNAs...
SnSe displaying a photothermal conversion capability and pyroelectric for efficient treatment of tumors.
Current hepatocellular carcinoma (HCC) risk scores do not reflect changes in HCC resulting from liver disease progression/regression over time. We aimed to develop and validate two novel prediction models using multivariate longitudinal data, with or without cell-free DNA (cfDNA) signatures.A total of 13,728 patients nationwide multicenter prospective observational cohorts, the majority whom had chronic hepatitis B, were enrolled. aMAP score, as one most promising models, was evaluated for...
In recent decades, hybrid imaging techniques that exploit the advantages of multiple technologies have aroused extensive attention due to deficiencies single modes. Along with development photon emission computed tomography-magnetic resonance (SPECT-MRI), it is currently necessary develop a series dual probes can combine outstanding sensitivity SPECT high spatial resolution MRI. Herein, commonly used technetium-99 (99mTc) was labelled on surface manganese oxide-based mesoporous silica...
Nanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide (H2O2). Among them, responsive chemodynamic therapy (CDT) utilized Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) destruction of cells. However, produced ·OH is easily depleted GSH tumors, which would undoubtedly...
Hepatitis B surface antigen (HBsAg) loss is the optimal outcome for patients with chronic hepatitis (CHB) but this rarely occurs currently approved therapies. We aimed to develop and validate a prognostic model HBsAg on treatment using longitudinal data from large, prospectively followed, nationwide cohort.
Abstract Lithium-ion batteries, celebrated for their high voltage, durability, and cleanliness, are the cornerstone of today’s new energy field. Their thermal stability in confined, explosion-proof settings is crucial high-risk industries like military mining, directly impacting worker safety equipment reliability. Insight into runaway triggers progression vital crafting preventive strategies enhancing battery system safety. This research, involving tests on three lithium-ion batteries an...
Objective: This paper investigated that the clinical value of modified first-level reconstruction reinforcement in prevention and treatment pelvic floor dysfunction after laparoscopic total hysterectomy. Methods: A 360 patients undergoing hysterectomy from December 2018 to September 2021 were selected divided into three groups (A, B, C) according POP-Q criteria: is a randomized trial which women with first- second-degree organ prolapse, without prolapse each 3 arms study. According informed...
Summary. The immune mechanism(s) that lead to hepatitis B‐related acute‐on‐chronic liver failure (HB‐ACLF) are poorly understood. Interleukin‐21 is a newly discovered cytokine involved in autoimmune and inflammatory diseases. Its potential role HB‐ACLF remains unknown. serum levels of 12 cytokines measured by cytometric bead arrays the frequency IL‐21‐secreting CD4 + T cells peripheral blood mononuclear (PBMC) intracellular staining were compared moderate chronic B (M‐CHB, n = 20), severe...
The role of NK cells against HIV-1 infections remains to be elucidated in vivo. While humanized mouse models potentially could used directly evaluate human cell responses during infection, improved functional development these hosts is needed. Here, we report the MISTRG-6-15 model, which were quick expand and exhibit degranulation, cytotoxicity, proinflammatory cytokine production nonlymphoid organs upon infection but had reduced functionality lymphoid organs. Although induced impairment...
Abstract The existence of statistical associations between hepatitis B‐related acute‐on‐chronic liver failure and both B virus (HBV) genotype mutations in the basal core promoter (BCP) precore (PC) regions needs to be confirmed. A total 322 patients with a chronic HBV infection, including 77 failure, 109 hepatocellular carcinoma (HCC) 136 (CHB) were enrolled. presence BCP/PC determined by direct sequencing, frequencies compared three patient groups. Overall, 198/322 (61.5%) infected 124/322...
Abstract Adoptive T lymphocyte immunotherapy is one of the most promising methods to treat residual lesions after glioma surgery. However, fate adoptively transferred T‐cells in vivo unclear, hampering understanding this emerging therapy. Thus, it highly desirable develop noninvasive and quantitative tracking these for better identification migratory provide objective evaluation outcomes adoptive T‐cell targeting glioma. In work, ultrasmall 1 MR‐based nanoprobes, NaGdF 4 ‐TAT, as molecular...
Nuclear localization of paramyxovirus proteins is crucial for virus life cycle, including the regulation viral replication and evasion host immunity. We previously showed that a recombinant Newcastle disease (NDV) with nuclear signal mutation in matrix (M) protein results pathotype change attenuates pathogenicity chickens. However, little known about functions NDV M protein. In this study, potential nucleus were investigated. first demonstrate could not only promote cytopathogenicity but...
Summary Background Obesity is typically associated with metabolic dysfunction, but its impact on hepatocellular carcinoma (HCC) remains unclear in patients chronic hepatitis B (CHB). Aim To study the effect of obesity HCC development CHB receiving antiviral therapy. Methods We included from a Chinese multicentre, prospective, observational, treated cohort this study. General was evaluated by body‐mass index (BMI). Central waist circumference, waist‐to‐hip ratio and waist‐to‐height ratio....
Cancer susceptibility candidate 9 (CASC9) is a recently identified lncRNA that acted as tumor promotor in diversified cancer types. However, its role papillary thyroid (PTC) remains unknown. The expression of CASC9 was measured 52 human PTC tissues and cell lines well their controls. proliferation, migration, invasion cells were determined after knockdown or overexpression to evaluate the effect on cells. Also, tumorigenesis confirmed mice xenograft models. Additionally, underlying...