A5101758302- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Selenium in Biological Systems
- RNA modifications and cancer
- DNA Repair Mechanisms
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Meningioma and schwannoma management
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Mass Spectrometry Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- Bladder and Urothelial Cancer Treatments
- Ubiquitin and proteasome pathways
- Renal and related cancers
- Ultrasound and Hyperthermia Applications
- Redox biology and oxidative stress
Huashan Hospital
2015-2025
Fourth Affiliated Hospital of Harbin Medical University
2009-2025
Harbin Medical University
2009-2025
First People's Hospital of Chongqing
2020-2024
Huadong Hospital
2020-2024
Fudan University
2015-2024
Credo Reference (United States)
2024
Jinzhou Medical University
2024
Weatherford College
2024
Institute of Biophysics
2024
BackgroundAbnormal construction of the extracellular matrix (ECM) is intimately linked with carcinogenesis and development solid tumours, especially hepatocellular carcinoma (HCC). As major component ECM, collagen plays a pivotal role in carcinogenesis. P4HA2, essential enzyme during formation, becomes an important target HCC treatment. Here, we tried to decipher whether aspirin (ASA), classic anti-inflammatory drug, could improve prognosis through targeting P4HA2.MethodsWestern blotting,...
Abstract Pituitary neuroendocrine tumor (PitNET) is one of the most common intracranial tumors. Due to its extensive heterogeneity and lack high-quality tissues for biomarker discovery, causative molecular mechanisms are far from being fully defined. Therefore, more studies needed improve current clinicopathological classification system, advanced treatment strategies such as targeted therapy immunotherapy yet be explored. Here, we performed largest integrative genomics, transcriptomics,...
Few effective treatment options exist for stroke beyond the hyperacute period. Radical generation and myeloperoxidase (MPO) have been implicated in stroke. We investigated whether pharmacologic reduction or gene deletion of this highly oxidative enzyme reduces infarct propagation improves outcome transient middle cerebral artery occlusion mouse model (MCAO). Mice were treated with 4-aminobenzoic acid hydrazide (ABAH), a specific irreversible MPO inhibitor. Three regimens used: (1) daily...
Resistance to tamoxifen (TAM) frequently occurs in the treatment of estrogen receptor positive (ER+) breast cancer. Accumulating evidences indicate that transcription factor HOXB13 is great significance TAM resistance. However, regulation TAM-resistant cancer remains largely unexplored. Here, we were interested potential effect HBXIP, an oncoprotein involved acceleration progression, on modulation resistance cancer.The Kaplan-Meier plotter database and GEO dataset used analyze association...
Abstract It is important but challenging to innovate inorganic sonosensitizers with controlled biodegradability and enhanced sonodynamic chemodynamic activities harness remodel the immunosuppressive tumor microenvironment (TME) for awakening robust immune responses against metastatic cancers. Herein rational design defect engineering strategy of a pH‐responsive biodegradable sonozyme system in sulfide nanocages augmented cancer immunotherapy reported. A series highly defective Co 9 S 8‐x...
A monomethylated selenium metabolite, called methylseleninic acid (MSA), has recently been shown to cause global thiol redox modification of proteins. These changes represent a form cellular stress due protein misfolding or unfolding. An accumulation aberrantly folded proteins in the endoplasmic reticulum (ER) triggers defined set transducers correct defects commit cells apoptosis if rescue effort is exhausted. Treatment PC-3 human prostate cancer with MSA was found induce number signature...
Purpose: The study reported here examined the effect of hematoporphyrin monomethyl ether (HMME)-mediated sonodynamic therapy (SDT) on C6 gliomas implanted in rat brains. Methods: Two weeks after inoculation, glioma development was evaluated by measuring tumor volume using a 1.5 T magnetic resonance imager. Rats that had well-developed (usually when diameter reached 3–5 mm) were used to test SDT, ultrasound-alone, and HMME-alone treatments. both administered not intravenous HMME 10 µg/mL...
The relationship between inflammation and neurogenesis in stroke is currently not well understood. Focal ischemia enhances cell proliferation the neurogenic regions, including subventricular zone (SVZ), dentate gyrus, as non-neurogenic striatum, cortex ischemic hemisphere. Myeloperoxidase (MPO) a potent oxidizing enzyme secreted during by activated leukocytes, its enzymatic activity highly elevated after stroke. In this study, we investigated whether inhibition of MPO specific irreversible...
High-mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that plays essential roles in embryonic development and cancer progression. However, the mechanism of HMGA2 regulation remains largely uncharacterized. Here, we demonstrate can be modulated by hepatitis B X-interacting protein (HBXIP), oncogenic transcriptional coactivator, esophageal squamous cell carcinoma (ESCC). expression was positively associated with HBXIP clinical ESCC tissues, their high levels were...
Abstract Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is a sequence-specific RNA-binding protein. We had reported that CPEB3 involved in hepatocellular carcinoma (HCC) progression. However, the underlying mechanisms of HCC remain unclear. In this study, we firstly performed RNA immunoprecipitation to uncover transcriptome-wide CPEB3-bound mRNAs (CPEB3 binder) HCC. Bioinformatic analysis indicates binders are closely related cancer progression, especially metastasis. Further...
Abstract The up-regulation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway is prevalent in many cancers. This phenomenon makes PI3K and Akt fruitful targets for cancer therapy and/or prevention because they are mediators cell survival signaling. Although suppression phospho-Akt by selenium has been reported previously, little information available on whether modulates primarily PI3K-phosphoinositide-dependent kinase 1 (PDK1) side phosphorylation or phosphatase dephosphorylation....
Taxanes are first line drugs for treating prostate cancer recurrence after the failure of anti-androgen therapy. There is a need to make taxanes more effective since they only provide palliative benefit. Exploiting endoplasmic reticulum (ER) stress death signaling enhance drug efficacy has not been delineated. Human PC-3 cells were used as model hormone refractory cancer. Thapsigargin and methylseleninic acid (MSA) examined sensitizers. classic ER inducer. The activity MSA in inducing...
The aim of this study was to the effects killing C6 glioma cells induced by hematoporphyrin monomethyl ether (HMME)-mediated sonodynamic therapy combined with photodynamic (SPDT). In SPDT group, were treated sonication at an intensity 0.5 W/cm(2) and a frequency 1 MHz, followed different doses light irradiation. growth inhibition rate following treatment determined MTT assay. apoptotic examined flow cytometry. Cleavage caspase 3, 8 9 investigated immunoblotting. Reactive oxygen species (ROS)...
Blocking 5α-reductase-mediated testosterone conversion to dihydrotestosterone (DHT) with finasteride or dutasteride is the driving hypothesis behind two prostate cancer prevention trials. Factors affecting intracellular androgen levels and receptor (AR) signaling axis need be examined systematically in order fully understand outcome of interventions using these drugs.The expression three 5α-reductase isozymes, as determined by immunohistochemistry qRT-PCR, was studied five human cell lines....
KRAS and TP53 mutations are the two most common driver in patients with lung adenocarcinoma (LUAD), they appear to reduce latency increase metastatic proclivity when a co-mutation (KRAS/TP53-mut) occurs. However, molecular mechanism involved is unclear. N6-methyladenosine (m6A), abundant RNA modification mammal mRNAs, plays critical role tumorigenesis. Here, we used genomic transcriptomic data found that only LUAD KRAS/TP53-mut, but not an individual mutation, appeared exhibit poor overall...