A5029146991- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Nanoplatforms for cancer theranostics
- Pituitary Gland Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Advanced Neuroimaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Meningioma and schwannoma management
- Nanoparticle-Based Drug Delivery
- Acute Ischemic Stroke Management
- Medical Imaging Techniques and Applications
- Adrenal and Paraganglionic Tumors
- Cerebrovascular and Carotid Artery Diseases
- Pregnancy and preeclampsia studies
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- Genetic Associations and Epidemiology
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Brain Metastases and Treatment
- Vascular Malformations Diagnosis and Treatment
- Luminescence Properties of Advanced Materials
Huashan Hospital
2016-2025
Fudan University
2016-2025
Huawei Technologies (China)
2024
Shanghai Cancer Institute
2016-2023
Center for Strategic Research
2023
Shanghai Institute of Hematology
2022
Houston Methodist
2020-2021
Hangzhou Normal University
2020
The Affiliated Yongchuan Hospital of Chongqing Medical University
2005-2019
Chongqing Medical University
2007-2019
Metallic glasses and cancer theranostics are emerging fields that do not seem to be related each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) their superior physicochemical properties compared crystalline counterpart, nanocrystals (FeNCs). The AFeNPs can used for by inducing a Fenton reaction in tumor taking advantage mild acidity overproduced H2 O2 microenvironment: Ionization enables on-demand ferrous ion release tumor, subsequent...
Surgical resection, one of the main clinical treatments intracranial glioblastoma, bears potential risk incomplete excision due to inherent infiltrative character glioblastoma. To maximize accuracy surgical magnetic resonance (MR) and fluorescence imaging are widely used for tumor preoperative diagnosis intraoperative positioning. However, present commercial MR contrast agents fluorescent dyes can only function single mode subject poor blood–brain barrier (BBB) permeability...
Abstract Metallic glasses and cancer theranostics are emerging fields that do not seem to be related each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) their superior physicochemical properties compared crystalline counterpart, nanocrystals (FeNCs). The AFeNPs can used for by inducing a Fenton reaction in tumor taking advantage mild acidity overproduced H 2 O microenvironment: Ionization enables on‐demand ferrous ion release tumor, subsequent...
SnSe displaying a photothermal conversion capability and pyroelectric for efficient treatment of tumors.
Cushing's disease results from corticotroph adenomas of the pituitary that hypersecrete adrenocorticotropin (ACTH), leading to excess glucocorticoid and hypercortisolism. Mutations deubiquitinase gene USP8 occur in 35-62% adenomas. However, major driver mutations wild-type tumors remain elusive. Here, we report recurrent USP48 (predominantly encoding p.M415I or p.M415V; 21/91 subjects) BRAF (encoding p.V600E; 15/91 with USP8. Similar mutants, both mutants enhance promoter activity...
Gd3+-based contrast agents (CAs) are the most prevailing and widely used for enhanced magnetic resonance imaging (MRI). Numbers of approaches have been developed to regulate key parameters in order obtain high-relaxivity CAs, according classic Solomon–Bloembergen–Morgen theory. Herein, a method controlling oxygen vacancies inorganic nanosized CAs has largely accelerated proton relaxation high r1 value. Such strategy is verified on oxygen-deficient PEG-NaxGdWO3 nanorods, which exhibit...
Background Noninvasive detection of isocitrate dehydrogenase 1 mutation (IDH1(+)) and loss nuclear alpha thalassemia/mental retardation syndrome X‐linked expression ((ATRX(–)) are clinically meaningful for molecular stratification low‐grade gliomas (LGGs). Purpose To study a radiomic approach based on multiparametric MR noninvasively determining status IDH1(+) ATRX(–) in patients with LGG. Study Type Retrospective, radiomics. Population Fifty‐seven LGG ( n = 36 19 17 ATRX(+) patients)...
In the field of nanomedicine, there is a tendency matching designed nanomaterials with suitable type orthotopic cancer model, not just casual subcutaneous one. Under this condition, knowing specific features chosen model priority, then introducing proper therapy strategy using nanomaterials. Here, Fenton chemistry combined zinc peroxide nanoparticles in treatment liver which has "chemical factory" including that main place for iron storage, metabolism, and also metabolic sites majority...
H3 K27M-mutant gliomas present heterogeneously in terms of pathology, imaging, and prognosis. This study aimed to summarize the imaging characteristics adult gliomas.
The spatiotemporal characterization of signaling crosstalk between subcellular organelles is crucial for the therapeutic effect malignant tumors. Blocking interactive in this fashion significant but challenging. Herein, a communication interception strategy reported, which blocks cancer therapy with underlying molecular mechanisms. Briefly, amorphous-core@crystalline-shell Fe@Fe3 O4 nanoparticles (ACFeNPs) are fabricated to specifically block lysosomes and endoplasmic reticulum (ER) by...
In recent decades, extensive attention has been paid to developing anatomic and functional imaging contrast agents that could provide a wealth of complementary bioimaging information. Among them, dual-mode nanoprobes combine magnetic resonance (MRI) with fluorescent have mostly used for separated imaging. However, the lack machine simultaneous greatly limits further clinical application. One effective strategy is rationally design MRI own both MR capability on single machine, which highly...
OBJECTIVE Treatment with a BRAF mutation inhibitor might shrink otherwise refractory craniopharyngiomas and is promising preoperative treatment to facilitate tumor resection. The aim of this study was investigate the noninvasive diagnosis BRAF-mutated based on MRI characteristics. METHODS Fifty-two patients pathologically diagnosed craniopharyngioma were included in study. Polymerase chain reaction performed tissue specimens detect CTNNB1 mutations. manifestations-including location, size,...
Inflammation drives the pathology of many neurological diseases. d-mannose has been found to exert an antiinflammatory effect in peripheral diseases, but its effects on neuroinflammation and inflammatory cells central nervous system have not studied. We aimed determine key macrophage/microglial functions-oxidative stress phagocytosis. In murine experimental autoimmune encephalomyelitis (EAE), we improved EAE symptoms compared phosphate-buffered saline (PBS)-control mice, while other...
Skull base chordoma (SBC) is a bone cancer with high recurrence rate, radioresistance and poorly understood mechanism. Here, we profiled the transcriptomes of 90,691 single cells, revealed SBC cellular hierarchies, explored novel treatment targets. We identified cluster stem-like cells that tended to be distributed in inferior part tumor. Combining radiated UM-Chor1 RNA-seq data vitro validation, further found this cell marked by cathepsin L (CTSL), gene involved packaging telomere ends, may...
The central nervous system (CNS) maintains homeostasis with its surrounding environment by restricting the ingress of large hydrophilic molecules, immune cells, pathogens, and other external harmful substances to brain. This function relies heavily on blood-cerebrospinal fluid (B-CSF) blood-brain barrier (BBB). Although considerable research has examined structure BBB, B-CSF received little attention. Therapies for disorders associated have potential benefit from targeting enhance medication...