A5006625728- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Advanced Photocatalysis Techniques
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- MXene and MAX Phase Materials
- Immunotherapy and Immune Responses
- Luminescence Properties of Advanced Materials
- Quantum Dots Synthesis And Properties
- Pancreatic function and diabetes
- Advanced Drug Delivery Systems
- Luminescence and Fluorescent Materials
- Electrocatalysts for Energy Conversion
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Nanocluster Synthesis and Applications
- SARS-CoV-2 detection and testing
- 2D Materials and Applications
- Fuel Cells and Related Materials
- Liver Disease Diagnosis and Treatment
- Carbon and Quantum Dots Applications
- Photoacoustic and Ultrasonic Imaging
- Water Systems and Optimization
Shanghai Tenth People's Hospital
2019-2025
Tongji University
2019-2025
Harvard University
2020-2024
Brigham and Women's Hospital
2020-2024
Shihezi University
2023-2024
University of Electronic Science and Technology of China
2023-2024
University of Wisconsin–Madison
2022-2023
Shanghai Institute of Ceramics
2017-2022
Chinese Academy of Sciences
2017-2022
Sichuan Normal University
2022
Several decades of research have identified the specific tumor microenvironment (TME) to develop promising nanotheranostics, such as pH-sensitive imaging, acidity-sensitive starving therapy, and hydrogen peroxide-activated chemotherapy, etc. Herein, a novel TME-mediated nanoplatform employing antiferromagnetic pyrite nanocubes is presented, exploiting intratumoral, overproduced peroxide for self-enhanced magnetic resonance imaging (MRI) photothermal therapy (PTT)/chemodynamic (CDT). Through...
The treatment of diabetic ulcer (DU) remains a major clinical challenge due to the complex wound-healing milieu that features chronic wounds, impaired angiogenesis, persistent pain, bacterial infection, and exacerbated inflammation. A strategy effectively targets all these issues has proven elusive. Herein, we use smart black phosphorus (BP)-based gel with characteristics rapid formation near-infrared light (NIR) responsiveness address problems. in situ sprayed BP-based could act as 1)...
Abstract Clay-based nanomaterials, especially 2:1 aluminosilicates such as vermiculite, biotite, and illite, have demonstrated great potential in various fields. However, their characteristic sandwiched structures the lack of effective methods to exfoliate two-dimensional (2D) functional core layers (FCLs) greatly limit future applications. Herein, we present a universal wet-chemical exfoliation method based on alkali etching that can intelligently “capture” ultrathin biocompatible FCLs (MgO...
The common existence of hypoxia in solid tumors has been heavily researched because it renders more resistant to most standard therapeutic methods, such as radiotherapy (RT), chemotherapy, and photodynamic therapy (PDT), is associated with a malignant phenotype poor survival patients tumors. development modulation methods for advanced activity therefore great interest but remains considerable challenge. Since the significant nanotechnology nanomedicine, functionalized nanomaterials can be...
Abstract Tailored to the specific tumour microenvironment, which involves acidity and overproduction of hydrogen peroxide, advanced nanotechnology has been introduced generate hydroxyl radical ( . OH) primarily for chemodynamic therapy (CDT) through Fenton Fenton‐like reactions. Numerous studies have investigated enhancement CDT efficiency, increase in amount OH generated. Notably, various strategies based on reaction employed enhance generation, including nanomaterials selection, modulation...
Chelating strategy and electron shuttle armed nanoagent for killing cancer cells at both an acidic neutral pH with high CDT efficiency.
Abstract Ultrasound (US)‐mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non‐invasiveness and high tissue‐penetrating depth. However, developing biocompatible nanomaterial‐based sonosensitizers with efficient SDT capability remains challenging. Here, we employed liquid‐phase exfoliation strategy obtain new type of two‐dimensional (2D) stanene‐based nanosheets (SnNSs) band gap 2.3 eV, which is narrower than those most extensively studied...
Arsenical drugs have achieved hallmark success in treating patients with acute promyelocytic leukemia, but expanding their clinical utility to solid tumors has proven difficult the contradiction between therapeutic efficacy and systemic toxicity. Here, leveraging efforts from materials science, biocompatible PEGylated arsenene nanodots (AsNDs@PEG) high monoelemental arsenic purity that can selectively effectively treat are synthesized. The intrinsic selective killing effect of AsNDs@PEG is...
Abstract The local electron density of an atom is one key factor that determines its chemical properties. Regulating can promote the atom's reactivity and so reduce reaction activation energy, which highly desired in many applications. Herein, we report intra‐crystalline lever strategy, regulate centre atoms via manipulating ambient lattice states, for Fenton activity improvement. Typically, with assistance ultrasound, Mn 4+ −O−Fe 3+ bond BiFe 0.97 0.03 O 3 perovskite nanocrystals drive...
SnSe displaying a photothermal conversion capability and pyroelectric for efficient treatment of tumors.
Abstract Biodegradable nanoprodrugs, inheriting the antitumor effects of chemotherapy drugs and overcoming inevitable drawback side on normal tissues, hold promise as next‐generation cancer therapy candidates. nanoprodrugs transferrin‐modified MgO 2 nanosheets are developed to selectively deliver reactive oxygen species cells for molecular dynamic strategy. The favor acidic low catalase activity tumor microenvironment react with proton release nontoxic Mg 2+ . This reaction simultaneously...