A5101421832- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Graphene and Nanomaterials Applications
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Flavonoids in Medical Research
- Galectins and Cancer Biology
- Phytochemistry and Biological Activities
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Colorectal Cancer Surgical Treatments
- Phytochemical compounds biological activities
- Bone Metabolism and Diseases
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Protease and Inhibitor Mechanisms
- Colorectal Cancer Treatments and Studies
- Prion Diseases and Protein Misfolding
- Carbon and Quantum Dots Applications
Nanjing University of Chinese Medicine
2013-2025
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Purple Mountain Laboratories
2023
Jiangsu Provincial Center for Disease Control and Prevention
2021-2022
The Synergetic Innovation Center for Advanced Materials
2022
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2020
Arsenical drugs have achieved hallmark success in treating patients with acute promyelocytic leukemia, but expanding their clinical utility to solid tumors has proven difficult the contradiction between therapeutic efficacy and systemic toxicity. Here, leveraging efforts from materials science, biocompatible PEGylated arsenene nanodots (AsNDs@PEG) high monoelemental arsenic purity that can selectively effectively treat are synthesized. The intrinsic selective killing effect of AsNDs@PEG is...
Colorectal tumors often create an immunosuppressive microenvironment that prevents them from responding to immunotherapy. Cannabidiol (CBD) is a non-psychoactive natural active ingredient the cannabis plant has various pharmacological effects, including neuroprotective, antiemetic, anti-inflammatory, and antineoplastic activities. This study aimed elucidate specific anticancer mechanism of CBD by single-cell RNA sequencing (scRNA-seq) ATAC (scATAC-seq) technologies. Here, we report inhibits...
Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is hopeful target for therapy, its relationship with innate immunosuppression remains elusive. To address that, single-cell RNA sequencing was performed to explore the role in all cell types microenvironment (TME) from murine MC38 xenografts. Intratumoral cells were found be functionally heterogeneous responded significantly SHP099, allosteric...
Objective: To evaluate the potential of hyaluronic acid (HA)-coated bovine serum albumin nanoparticles (BSANPs) as a novel chondrocyte-targeting drug-delivery nanomedicine. Methods: The HA-BSANPs were characterized by dynamic light scattering, transmission electron microscopy, differential scanning calorimetry, and X-ray diffraction. Fluorescence imaging was used to visualize distribution after intra-articular injection. efficiency cellular uptake mechanism investigated using endocytic...
Exosomes are extracellular vesicles secreted by most cells to deliver functional cargoes recipient cells. MicroRNAs (miRNAs) constitute a significant part of exosomal contents. The ease diffusion exosomes renders them speedy and highly efficient vehicles molecules. Cancer secrete more than normal Reports have showed that miRNAs cancer facilitate progression. Yet the complexity dictates many remain be discovered.In this study, we analyzed miRNA expression profiles tissue plasma exosome...
Abstract Background Some natural compounds inhibit cancer cell growth in various lines with fewer side effects than traditional chemotherapy. Here, we explore the pharmacological and mechanisms of worenine (isolated from Coptis chinensis ) against colorectal cancer. Methods The on proliferation, colony formation cycle distribution were measured. Glycolysis was investigated by examining glucose uptake consumption, lactate production, activities expressions glycolysis enzymes (PFK-L, HK2...
Colon cancer remains one of the most prevalent cancers worldwide. Unfortunately, there are no recognized and effective therapeutic strategies to prevent tumor recurrence after radical resection chemotherapy, disease-free survival (DFS) in patients with stage IIIB or IIIC disease unsatisfactory. Xian-Lian-Jie-Du optimization decoction (XLJDOD) is a Chinese herbal medicine (CHM) empirical prescription, which has been validated experimentally clinically that could inhibit progression colorectal...
Background Previous investigations have demonstrated a correlation between the composition of gut microbiota and development thyroid cancer (TC). Nonetheless, there was no consensus on causal effect TC risk. Therefore, present study aimed to perform bidirectional two-sample Mendelian randomization (MR) analysis explore potential associations Methods Utilizing data from MiBioGen consortium’s genome-wide association studies (GWAS) meta-analysis involving sample size 18,340, we identified...
Abstract As a critical component of the tumour immune microenvironment (TIME), resident microbiota promotes tumorigenesis across variety cancer types. Here, we integrated multiple types omics data, including microbiome, transcriptome, and metabolome to investigate functional role intratumoral bacteria in gastric (GC). The microbiome was used categorize GC samples into six subtypes, patients with high abundance Streptococcus or Pseudomonas had markedly worse prognosis. Further assays revealed...
Pancreatic cancer remains one of the cancers with poorest prognosis bearing an overall 5-year survival rate about 5%. Efficient new chemotherapic drugs are still highly desired. Here, bruceine A, a quassinoid identified from dried fruits Brucea javanica (L.) Merr., displayed most potent anti-proliferation activity against pancreatic in vitro and vivo. Phosphoproteomic analysis revealed p38α MAPK phosphorylation was involved A's action MIA PaCa-2 cells. Utilizing fortebio octet system...
A comprehensive strategy was designed for the quality assessment of Fructus Ligustri Lucidi, a well-known and commonly used herbal medicine in clinical practice China. First, simple stable method high-performance liquid chromatography developed simultaneous quantitative analysis six compounds, namely, salidroside, nuzhenide, specnuezhenide, oleanic acid, ursolic acetyl acid Lucidi. The separation analytes conducted on C18 column (200 mm × 4.6 mm, 5 μm) at 30°C, wavelength UV detector set 210...
Colorectal cancer (CRC) ranks among the leading causes of cancerrelated deaths.
Multiple organ dysfunction syndrome (MODS) is one of the leading causes death in critically ill patients. MODS result a dysregulated inflammatory response that can be triggered by various causes. Owing to lack an effective treatment for patients with MODS, early identification and intervention are most strategies. Therefore, we have developed variety warning models whose prediction results interpreted Kernel SHapley Additive exPlanations (Kernel-SHAP) reversed diverse counterfactual...
Abstract Background: Colorectal Adenomatous Polyp (CAP) was one precursor of colorectal cancer (CRC) and having a high chance developing into CRC. There lack conclusive chemoprevention evidences to prevention new CAP occurrence in post-polypectomy. Xiaoai Jiedu Decoction , Chinese National Medical Professor (Zhou Zhongying)'s experience formula, has been used treat post-polypectomy from the 20th century China. However, clinical research treatment recurrence lack. We design this study...
Oxaliplatin can cause severe peripheral neurotoxicity, which is an important reason for clinical oxaliplatin reduction and cessation of treatment. induced neurotoxicity (OIPN) paresthesia dysesthesia, even affect the quality life patients. So far, there are no recognized effective measures to prevent OIPN. Huangqi Guizhi Wuwu decoction a classical prescription ancient Chinese medicine recorded in "the synopsis Golden Chamber," be used treatment various neurotoxicity. However, lack...
The epithelial-mesenchymal transition (EMT) program, which loosens cell-cell adhesion complexes, endows cells with enhanced migratory and invasive properties. Furthermore, this process facilitates both the development of drug resistance immunosuppression by tumor cells, preclude successful treatment cancer. Recent research has demonstrated that many signaling pathways are involved in EMT progression. In addition, cancer stem (CSCs), vasculogenic mimicry (VM) tumor-related immune...