A5103269524- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Medical Imaging Techniques and Applications
- Oral microbiology and periodontitis research
- Neuroendocrine Tumor Research Advances
- Head and Neck Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Pituitary Gland Disorders and Treatments
- Gastrointestinal Tumor Research and Treatment
- Oral Health Pathology and Treatment
- Colorectal Cancer Treatments and Studies
- Thyroid Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Pathology Studies
- Radiation Therapy and Dosimetry
- Ophthalmology and Eye Disorders
- Barrier Structure and Function Studies
- Gastrointestinal disorders and treatments
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
Zhejiang Chinese Medical University
2023-2025
Chinese Academy of Sciences
2024
Zhejiang Cancer Hospital
2023-2024
Shanghai Jiao Tong University
2023
Shanghai Ninth People's Hospital
2011-2023
Abstract Background The investigational use of zolbetuximab (IMAB362), a groundbreaking monoclonal antibody medication targeting claudin 18.2 (CLDN18.2), for treatment advanced gastrointestinal cancers is currently underway. unclear clinicopathological characteristics and tumour immune microenvironment CLDN18.2-positive gastric cancer (GC) make it difficult to develop optimize CLDN18.2-targeted therapies. Methods A total 451 tissues, 342 matched paraneoplastic 107 metastatic lymph nodes were...
Body mass index (BMI) is considered an important factor in tumor prognosis, but its role gastric cancer (GC) remains controversial. There a lack of studies exploring the effect BMI on from perspective intratumoral microbiota. This study aimed to compare and analyze differences functions microbiota among GC patients with varying BMIs, aiming ascertain whether specific microbial features are associated prognosis low-BMI (LBMI) patients. A retrospective analysis clinicopathological 5567...
Digestive system tumours (DSTs) often diagnosed late due to nonspecific symptoms. Non-invasive biomarkers are crucial for early detection and improved outcomes. We collected tongue coating samples from 710 patients with DST 489 healthy controls (HC) April 2023, December 2023. Microbial composition was analyzed using 16S rRNA sequencing, five machine learning algorithms were applied assess the diagnostic potential of microbiota. Alpha diversity analysis showed that microbial in significantly...
Abstract Objective This study aimed to explore the clinicopathological characteristics and prognostic implications of gastric neuroendocrine neoplasms (g‐NENs). Methods A retrospective enrollment 142 patients diagnosed with g‐NENs was conducted at Zhejiang Cancer Hospital between January 1, 2007 December 31, 2021. The compared essential features survival rates. Additionally, prognosis carcinomas/mixed neuroendocrine–non‐neuroendocrine (g‐NEC/MiNEN) were contrasted those adenocarcinoma (GAC)...
Abstract As a critical component of the tumour immune microenvironment (TIME), resident microbiota promotes tumorigenesis across variety cancer types. Here, we integrated multiple types omics data, including microbiome, transcriptome, and metabolome to investigate functional role intratumoral bacteria in gastric (GC). The microbiome was used categorize GC samples into six subtypes, patients with high abundance Streptococcus or Pseudomonas had markedly worse prognosis. Further assays revealed...
Intravenous glucocorticoid (IVGC) remains the main treatment for moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). However, a substantial number (20-30%) of TAO patients may not respond to IVGC. Some have disease progression despite IVGC or relapse after steroid withdrawal.To analyze risk factors clinical activity predictive outcomes 4.5 g therapy in with TAO.Our study was performed two steps: step 1 involved 110 analyzed activity; 2 53 from who were treated therapy....
<title>Abstract</title> Body mass index (BMI) is considered a significant prognostic factor for tumor outcomes;however, the role of BMI in gastric cancer (GC) remains controversial. Currently, there lack research investigating impact on GC from perspective intratumoral microbiota. This study aimed to compare and analyze differences functions microbiota among patients with varying BMIs, aiming ascertain whether specific microbial features are associated prognosis low-BMI patients.A...
<title>Abstract</title> Background Early-onset gastric cancer (EOGC, ≤ 45 years) exhibits distinct clinicopathological characteristics, and its incidence is rising. This study aims to offer insights into treatment strategies for patients across different age groups by retrospectively analyzing the features, distant metastasis patterns, prognostic factors of EOGC patients. Methods We performed a retrospective analysis data from 33,675 in Surveillance, Epidemiology, End Results database...
Objective To prospectively compare the clinical effect of 131I therapy for Graves disease (GD) using 131I-iodide dose determined by radioactive iodine uptake formula and individualized experience method respectively. Methods (1) A total 527 GD patients referred were enrolled divided into two groups interval sampling method. Group 1 consisted 241 with their activity calculated formula. 2 286 based on experience. (2) The who not cured first time retreated after 3 months in same way...
Abstract Background: There is controversy over whether tumor location affects the prognosis of GIST. The objective this study to compare clinicopathological features and overall survival (OS) rates gastrointestinal stromal tumors (GISTs) in stomach small bowel, as well identify independent prognostic factors predict OS for Methods: A total 504 patients who underwent surgical treatment GIST between 2005 2020 were included retrospective cohort study. with bowel was compared those gastric using...