A5100364957- Liver Disease Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Arsenic contamination and mitigation
- Microbial Natural Products and Biosynthesis
- RNA modifications and cancer
- Diet, Metabolism, and Disease
- MicroRNA in disease regulation
- Diet and metabolism studies
- Endoplasmic Reticulum Stress and Disease
- Thyroid Disorders and Treatments
- Extracellular vesicles in disease
- Liver Disease and Transplantation
- RNA Interference and Gene Delivery
- Peroxisome Proliferator-Activated Receptors
- RNA Research and Splicing
- Bacterial Genetics and Biotechnology
- Metabolism and Genetic Disorders
- Marine Sponges and Natural Products
- Optical Coherence Tomography Applications
- Heavy Metal Exposure and Toxicity
- Photoacoustic and Ultrasonic Imaging
- Autism Spectrum Disorder Research
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Neuroinflammation and Neurodegeneration Mechanisms
Central South University
2022-2024
Wenzhou Medical University
2022-2024
Northeastern University
2020-2024
Beijing Proteome Research Center
2020-2023
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023
Anhui Medical University
2022-2023
Zhejiang Cancer Hospital
2023
Chinese Academy of Sciences
2009-2023
China Medical University
2008-2023
Jiangnan University
2023
A novel self-powered photodetector based on reduced graphene oxide (rGO)/n-Si p-n vertical heterojunction with high sensitivity and fast response time is presented. The contains a between drop-casted rGO thin film n-Si. Contacts the semiconductor layer (rGO, n-Si) source-drain Ti/Au electrodes allow efficient transfer of photogenerated charge carriers. UV-near infrared shows toward spectrum light from 365 to 1200 nm. Under 600 nm illumination (0.81 mW cm-2 ), device has photoresponsivity...
Background: Extracellular vesicles (EVs) are considered a promising drug delivery platform.Naïve EVs face numerous issues that limit their applications, such as fast clearance, hepatic accumulations, and lack of target-specific tropism.We aimed to explore series surface engineering approaches to: 1) reduce the non-specific adhesion EVs, 2) improve enrichment in target tissue.As proof-of-concept, we investigated therapeutic potentials multi-modal system carrying tumor-specific nanobody...
Two novel cyclic hexapeptides containing both anthranilic acid and dehydroamino units, sclerotides A (1) B (2), were isolated from the marine-derived halotolerant Aspergillus sclerotiorum PT06-1 in a nutrient-limited hypersaline medium. Both 1 2 are photointerconvertible could be interconverted via radical reaction initiated by direct photoisomerization. compounds showed moderate antifungal activity. Compound also weak cytotoxicity antibacterial
Inteins are internal protein sequences that post-translationally self-excise and splice together the flanking sequences, so-called exteins. Natural engineered inteins have been used in many practical applications. However, often inefficient or inactive when placed a non-native host may require presence of several amino acid residues native exteins, which will then remain as potential scar spliced protein. Thus, more general overcome these limitations highly desirable. Here we report...
Streptocarbazoles A (1) and B (2), two novel indolocarbazoles featuring unprecedented cyclic N-glycosidic linkages between 1,3-carbon atoms of the glycosyl moiety indole nitrogen indolocarbazole core, were isolated from marine-derived actinomycetes strain Streptomyces sp. FMA. Their structures established by spectroscopic methods, CD spectra, ECD quantum mechanical calculations. Compound 1 was cytotoxic on HL-60 A-549 cell lines could arrest cycle Hela cells at G2/M phase.
Two new indole-diterpenoids (1 and 2) a isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic (11) kojic (12), were isolated from fermentation broth of marine-derived fungus, Aspergillus flavus OUCMDZ-2205. The structures Compounds 1–12 elucidated by spectroscopic analyses, quantum ECD calculations chemical method. New Compound 1 exhibited antibacterial...
Early-life exposure to environmental endocrine disruptors (EDCs) is a potential risk factor for autism spectrum disorder (ASD). Exposure nonylphenol (NP), typical EDC, known cause some long-term behavioural abnormalities. Moreover, these abnormal behaviours are the most frequent psychiatric co-morbidities in ASD. However, direct evidence link between NP early life and ASD-like phenotypes still missing. In present study, induced by valproic acid treatment were considered as positive control....
Objective. To assess the feasibility of a new method measuring attenuation coefficient in liver, which offers less variability results than conventional method. Methods. The was evaluated on basis following equation with sound field correction: In our system, also by spectral shift central frequency at same time. We used 44 cases normal 40 fatty and 20 cirrhotic liver system. Results. With this method, values were 0.59 ± 0.10 dB • cm−1 MHz−1 livers, 0.80 0.12 0.62 0.09 livers. both methods...
Identification of protein methylation sites typically starts with database searching MS/MS spectra proteolytic digest the target by allowing addition 14 and 28 Da in selected amino acid residues that can be methylated. Despite progress our understanding lysine arginine methylation, substrates functions at other remain unknown. Here we report analysis for p53, SMC3, iNOS, MeCP2. We found a large number peptides modified on lysine, arginine, histidine, glutamic mass increase or Da, consistent...
Arsenic (As) is one of the most important toxic elements in natural environment. Currently, although assessment potential health risks chronic arsenic poisoning has received great attention, research on effects brain still limited. It been reported that dictyophora polysaccharide (DIP), a common bioactive compound found dietary plants, could reduce toxicity. Following behavioral research, comparative proteomics was performed to explore molecular mechanism toxicity hippocampi SD (Sprague...
Abstract Background Chronic inflammation contributes to the progression of isoproterenol (ISO)‐induced heart failure (HF). Caspase‐associated recruitment domain (CARD) families are crucial proteins for initiation in innate immunity. Nonetheless, relevance CARDs ISO‐driven cardiac remodelling is little explored. Methods This study utilized Card9 −/− mice and reconstituted C57BL/6 with either or Otud1 marrow‐derived cells. Mechanistic studies were conducted primary macrophages, cardiomyocytes,...
Head and neck cancer is the seventh most common in world, of which about 90% are head squamous cell carcinoma (HNSCC). Frequent alterations PIK3CA HNSCC suggest that PI3Kα a promising target for treatment. CYH33 novel PI3Kα-selective inhibitor discovered by our group, currently undergoing phase I clinical trial (NCT03544905) treatment advanced solid tumors, including HNSCC. However, there an urgent need to elucidate its mechanism action improve efficacy against In this study, we found...
Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) is a facile technique for quantitative analysis of RNA secondary structure. In general, low SHAPE signal values indicate Watson-Crick base-pairing, and high positions that are single-stranded within the However, relationship signals to structural properties such as non-Watson-Crick base-pairing or stacking has thus far not been thoroughly investigated. Here, we present results experiments performed on several RNAs with...
Abstract Bovine milk is rich in extracellular vesicles (mEVs) which have been suggested as a possible drug delivery vehicle with oral bioavailability. As the digestive fluids contain many lipid‐ and protein‐degrading enzymes, we explored whether mEVs given sublingually could be taken up systemically. were isolated using three different protocols, 120 nm diameter carried bovine CD81. Fluorescently stained by sublingual route detected circulation, whereas gavage at 2‐Log lower concentrations....
Non-alcoholic fatty liver disease (NAFLD) is associated with mutations in lipopolysaccharide-binding protein (
Abstract Background As the third enzyme of pentose phosphate pathway, 6-phosphogluconate dehydrogenase (6PGDH) is main generator cellular NADPH. Both thioredoxin reductase and glutathione require NADPH as electron donor to reduce oxidized or (GSSG). Since GSH are important antioxidants, it not surprising that 6PGDH plays a critical role in protecting cells from oxidative stress. Furthermore activity associated with several human disorders including cancer Alzheimer's disease. The 3D...