A5101725722- Arsenic contamination and mitigation
- Heavy Metal Exposure and Toxicity
- Fungal Biology and Applications
- Retinoids in leukemia and cellular processes
- Linguistic Variation and Morphology
- Fluoride Effects and Removal
- Aluminum toxicity and tolerance in plants and animals
- Autophagy in Disease and Therapy
- Heavy metals in environment
- Polysaccharides and Plant Cell Walls
- Phonetics and Phonology Research
- Gut microbiota and health
- Environmental Justice and Health Disparities
- China's Ethnic Minorities and Relations
- Bone and Dental Protein Studies
- Trace Elements in Health
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Forest, Soil, and Plant Ecology in China
- Rangeland Management and Livestock Ecology
- PAPR reduction in OFDM
- Heart rate and cardiovascular health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Hypoxia, and Metabolism
- Bone Metabolism and Diseases
Guiyang Medical University
2013-2025
Zhujiang Hospital
2024-2025
Southern Medical University
2021-2025
Affiliated Hospital of Guizhou Medical University
2021-2025
Ningbo University
2025
First People’s Hospital of Jingmen
2024
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2024
Chengdu Institute of Biology
2002-2022
Chinese Academy of Sciences
2002-2022
First Affiliated Hospital of Jiamusi University
2021
Inorganic arsenic (iAs) is a well-known human carcinogen recognized by the World Health Organization and International Agency for Research on Cancer. Currently, most iAs studies in populations are concerned with drinking water occupational arsenicosis. In Guizhou province, arsenicosis caused burning of coal unventilated indoor stoves an unusual type exposure. Because poisoning mechanism involved as yet unknown no effective therapy exists, progress has been slow prevention
Currently, most arsenic (As) studies in populations are concerned with water-borne arsenicosis. However, residents Xingren County of Guizhou Province, Southwest China, represent a unique case arsenicosis which is related to indoor combustion high As-containing coal. This study aimed assess the alterations As levels and its risk factors coal-borne during past 20 years. Four follow-up investigations were selected from year 1998 2017, total 245, 272, 584, 309 involved four investigations,...
Grifola frondosa is an edible medicinal mushroom that has been proven to have a variety of health benefits. The main active ingredients this are polysaccharides. In study, ultrasonic-assisted extraction was used obtain crude polysaccharides (GFPs). Then, purified GFP obtained after purification. optimum conditions were time 71 min, temperature 90°C in solid-to-liquid ratio 1:37 g/mL, and ultrasonic power 500 W. using DEAE-52 Sephadex G-100. structural characterization performed Fourier...
Arsenic (As) is a toxic element, and long-term exposure to As can cause neurotoxicity. The bioactive natural compound Dictyophora polysaccharide (DIP) from edible plants has been reported reduce the toxicity of As. In this study, poisoning was simulated by feeding As-containing feed, followed proteomic analysis after one month DIP treatment. showed that 145, 276, 97 proteins were differentially expressed between As-treated rats control (As/Ctrl group), DIP-treated + (DIP As/As As/Ctrl...
Gut microbiota dysbiosis significantly impacts ulcerative colitis (UC) progression and exacerbation. Probiotics show promise in UC management. This study evaluated the effects of different doses Bacillus pumilus LV149, an aquatic-derived probiotic, on gut injury repair male C57BL/6 mice with dextran sulfate sodium (DSS)-induced investigated underlying mechanisms. was induced by allowing free access to a 3% DSS solution for 7 days, concurrent daily oral gavage either low (LV149-L, 1 × 108...
Abstract Composable visualization is essential in biomedical research, particularly when working with complex, multi-dimensional biological data. However, many existing tools focus on specific fields and lack the comprehensive features needed to capture intricacies interrelations of datasets. To address this, we introduce ggalign, an R package built grammar graphics framework, providing easy-to-use platform for creating composable visualizations interconnected It offers a variety layout...
ABSTRACT The purpose of this study was to evaluate the combined effects puerarin (Pue) and insoluble dietary fiber from Hericium erinaceus (HEIDF) on obesity induced by a high-fat diet (HFD) in mice, focusing their lipid glucose metabolism, gut microbiota (GM), serum metabolites. Glucose tolerance, tissue pathology, biochemical levels were conducted assess with Erinaceus (LH) metabolism. 16S rRNA sequencing untargeted metabonomics employed explore underlying mechanisms. results showed that...
Abstract Transarterial chemoembolization (TACE) is considered the main treatment for intermediate and advanced liver cancer. Nevertheless, TACE may aggravate fibrosis in these patients, which could affect therapeutic effect after TACE. Pirfenidone (PFD) exhibits significant antifibrotic effects liver, primarily via inhibition of hepatic stellate cells (HSCs) activation. However, owing to high dose required effective treatment, oral administration PFD associated with several side effects....
Arsenic (As) is one of the most important toxic elements in natural environment. Currently, although assessment potential health risks chronic arsenic poisoning has received great attention, research on effects brain still limited. It been reported that dictyophora polysaccharide (DIP), a common bioactive compound found dietary plants, could reduce toxicity. Following behavioral research, comparative proteomics was performed to explore molecular mechanism toxicity hippocampi SD (Sprague...
Obesity is positively correlated with the occurrence of many chronic diseases, and its incidence has increased at an astonishing rate in recent two decades. Strategies based on dietary modification to prevent treat obesity are low-cost, widely available, highly scalable. Edible fungi rich variety, high nutritional value, contain a variety active ingredients. Based this, this paper briefly describes molecular mechanisms development more common ingredients edible fungi. It also outlines how...
The food industry is constantly seeking bioactive molecules from natural sources, using recyclable and sustainable strategies for effective use preventive therapeutic purposes. Dictyophora genus, considered to be a well-known homology plant of or medicine, has considerable great health benefits market utilization value. Guizhou recently attract the interest experts owing its vast benefits. production processing genus produces large number by-products (pileus, volva stipe) with limited...
The present paper analyzes the changes in migration patterns of a Tibetan-style transhumance livelihood system for period 20 years northwest Yunnan, China. Between 1984 and 2005, average number pastures rotational use 12 investigated villages decreased from 6.2 to 3.9, stops on annual route 8.3 5.8. days during which animals depend stall feeding low-elevation shrubs increased 231.3 270, while those spent forest belts by 32.6% alpine rangelands 25.5%. These have intensified pressure...
Objective . Depression is a common mental disease with long course and high recurrence rate. Previous studies showed that Puerariae Radix its extracts have powerful antidepressant effects in recent years. The study proposed an integrated strategy, combining network pharmacology molecular experiment to investigate the mechanisms of active ingredients from Radix. Methods TCMSP database, GeneCards Venny 2.1, UniProt STRING Cytoscape 3.7.2, Metascape database were used screen chemical...
Chronic arsenic exposure is a risk factor for human fatty liver disease, and the ERK signaling pathway plays an important role in regulation of lipid metabolism. However, whether progression arsenic-induced metabolism disorder specific mechanism remain unclear. Here, by constructing rat model induced chronic exposure, we demonstrated that might regulate disorders through PPAR pathway. Arsenic could upregulate expression PPARγ CD36 liver, decrease PPARα CPT-1 increase organ coefficient...