A5100396704- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Bariatric Surgery and Outcomes
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Immune cells in cancer
- Lipid metabolism and disorders
- Heat shock proteins research
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Diet and metabolism studies
- Body Contouring and Surgery
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Mesenchymal stem cell research
- Signaling Pathways in Disease
- Phagocytosis and Immune Regulation
Changzhou No.2 People's Hospital
2020-2025
Nanjing Traditional Chinese Medicine Hospital
2025
Nanjing Medical University
2020-2024
University of California, Davis
2018-2024
Guiyang Medical University
2023
First Affiliated Hospital of Xiamen University
2023
Dalian Medical University
2021
Huazhong University of Science and Technology
2021
Qilu Hospital of Shandong University
2021
Shandong University
2021
Abstract YT521‐B homology (YTH) domain family (YTHDF) proteins serve as readers that directly recognise m6A modifications. In this study, we aim to probe the role of YTHDF1 in environmental carcinogen‐induced malignant transformation gastric cells and cancer (GC) carcinogenesis. We established a long‐term low‐dose MNU‐induced model epithelial cells. vivo vitro experiments were conducted validate phenotype characterise roles its downstream genes Additionally, explored modification targets...
Collagen type X alpha 1 (COL10A1) is a member of the collagen family and main matrix component. However, COL10A1 expression prognosis relationship remains unclear in gastric cancer (GC). Through analysis database Oncomine, Cancer Genome Atlas (TCGA) as well Gene Expression Omnibus (GEO), contrast to tissue normal gastric, cancer, had been upregulated. The high was obviously related T stage (P = 0.025) lymph node metastasis 0.025). It has illustrated by logistic regression that COL10A1's...
Grifola frondosa is an edible medicinal mushroom that has been proven to have a variety of health benefits. The main active ingredients this are polysaccharides. In study, ultrasonic-assisted extraction was used obtain crude polysaccharides (GFPs). Then, purified GFP obtained after purification. optimum conditions were time 71 min, temperature 90°C in solid-to-liquid ratio 1:37 g/mL, and ultrasonic power 500 W. using DEAE-52 Sephadex G-100. structural characterization performed Fourier...
Cancer incidence and development are strongly correlated with obesity, however there is insufficient data to support a causal relationship between intentional weight loss the prevention or promotion of cancer. We investigated following Roux-en-Y gastric bypass (RYGB) 18 cancers using Mendelian randomization (MR). A genome-wide association studies (GWAS) related RYGB from GWAS catalog database were used as exposure, Medical Research Council integrative epidemiology unit open project outcomes....
As the most common chronic liver disease around world, nonalcoholic fatty (NAFLD) has a close connection with obesity, diabetes, and metabolic syndrome. Bariatric surgery (BS) is considered to be effective treatment for NAFLD. However, regulatory mechanism of hepatic lipid metabolism after BS remains poorly elucidated. By analyzing two transcriptome datasets regarding tissues BS, namely, GSE83452 GSE106737, we acquired 110 differentially expressed genes (DEGs). further analysis DEGs in terms...
We previously showed that α3β1 integrin is a novel cancer biomarker and drug target in non-small cell lung (NSCLC). This study characterized the α3 (ITGA3) expression on patient specimens.Tissue microarrays (TMAs) were prepared from archival tissue blocks containing 161 patients, which included 91 adenocarcinoma (LUAD), 46 squamous carcinomas (LUSC), 24 other histology types. TMA sections stained scored for ITGA3 by immunohistochemistry (IHC). Kaplan-Meier curves log-rank tests used to...
ABSTRACT Background & Aims tRFs (tRNA‐derived RNA fragments) have been reported to facilitate cancer progression in multiple cancers. However, their role pancreatic ductal adenocarcinoma (PDAC) remains be determined. In this study, we mainly investigated the expression of tRF‐Pro‐CGG and evaluated its relationship with clinicopathology survival time patients. Methods 37 cases adenocarcinoma, 15 normal tissues were collected which resected by surgery from January 2017 June 2020 Department...
Bariatric surgery (BS) is a dependable method for managing obesity and metabolic diseases, however, the regulatory processes of lipid metabolism are still not well elucidated. Differentially expressed genes (DEGs) were analysed through three transcriptomic datasets GSE29409, GSE59034 GSE72158 from GEO database regarding subcutaneous adipose tissue (SAT) after BS, 37 DEGs identified. The weighted gene co-expression network analysis (WGCNA), last absolute shrinkage selection operator (LASSO)...
Abstract Hepatocellular carcinoma (HCC) poses a significant clinical challenge, necessitating the integration of immunotherapeutic approaches. Palbociclib, selective CDK4/6 inhibitor, has demonstrated promising efficacy in preclinical HCC models and is being evaluated as novel therapeutic option trials. Additionally, inhibition induces cellular senescence, potentially influencing tumor microenvironment immunogenicity cancer cells. In this study, we conducted comprehensive bioinformatic...
Cell division cycle-associated protein-3 (CDCA3) contributes to the regulation of cell cycle. CDCA3 plays an important role in carcinogenesis various cancers; however, association between expression, prognosis patients, and immune infiltration tumor microenvironment is still unknown. Here, we demonstrated that was differentially expressed tissues corresponding normal using silico analysis ONCOMINE Tumor Immune Estimation Resource (TIMER) databases. We analyzed relationship expression...
Colorectal cancer (CRC) is one of the most mortal cancers in world. Multiple factors and bio-processes are associated with tumorigenesis metastasis CRC, including cellular senescence immune evasion. This study aims to identify prognostic immune-meditating effects INHBA CRC. Microarray datasets were downloaded from Gene Expression Omnibus (GEO) database screen differentially expressed genes (DEGs) senescent cells CRC tissues Cancer Genome Atlas (TCGA). Key factor was settled alternative DEGs...
Abstract Glioblastoma (GBM) is the most aggressive glioma, and prone to develop resistance chemotherapy radiotherapy; hence, patients with glioblastoma have a high recurrence rate low 1‐year survival rate. In addition, pathogenesis of complex largely unknown, available treatments are limited. Here, we uncovered fundamental role DYRK1A in regulating NFATC1 GBMs. We found that was highly expressed glioma cells, its expression positively correlated NFATC1. Moreover, inhibition promoted...
Human papillomavirus (HPV) status is a favorable prognostic marker for patients with oropharyngeal squamous cell carcinoma (OPSCC) and non-metastatic head neck non-OPSCC. We evaluated the impact of HPV on overall survival (OS) Stage IVC non-OPSCC.Patients diagnosed non-OPSCC known between 2010-2013 were identified in National Cancer Database. Univariate multivariate analyses performed to determine factors associated OS. Propensity score-weighted Kaplan-Meier estimation was used adjust...
Nonalcoholic steatohepatitis (NASH) is one of the most common chronic liver diseases worldwide and no effective drugs or treatments have been approved for disease management. Recently, bariatric surgery (BS) considered to be a novel disease-modifying therapy NASH metabolic diseases, according clinical follow-up studies. Despite revealment physiopathological alterations, underlying mechanisms key factors remain indeterminate. This study included multiple bulk RNA-sequencing datasets...
To reveal the mechanisms of effects mortalin in hepatocellular carcinoma (HCC) and to identify potential novel chemical inhibitors mortalin.
Gastric cancer (GC) remains a huge challenge to the heathy of human beings, largely due lacking effective therapeutic measures. Though an oncogenic role for circular RNAs (circRNAs) circ_0067997 in progression GC has been described recently, molecular modulatory mechanism it still be further explored. The aim present study is examine network GC.qRT-PCR was carried out determine mRNA levels circ_0067997, miR-615-5p and AKT1 cisplatin (DDP)-insensitive or sensitive tumor tissues cells, while...
Abstract Background Lack of biomarkers and in vitro models has contributed to inadequate understanding the mechanisms underlying inferior clinical response immune checkpoint inhibitors (ICIs) patients with oncogene-driven non-small cell lung cancer (NSCLC). Methods The effect small molecule tyrosine kinase (TKIs) on peripheral blood mononuclear cells (PBMCs) 34 NSCLC (cohort A) was compared those from 35 without mutations received ICI B) or 22 treatment-naïve C). Data for each biomarker were...
Sleeve gastrectomy (SG) is the most currently popular operation for obesity and related metabolic disorders. The aim of this study was to compare effect antrum preservation SG (AP-SG) resection (AR-SG) on body composition, glycemic control bone mineral density (BMD) in mice.Sham, AP-SG AR-SG were performed obese T2D C57BL/6J mice (8 each group). Body weight, food intake, fasting glucose (FG) levels measured at 0, 2, 4, 6 8 weeks post-operatively. Oral tolerance test (OGTT) preoperatively...