A5021639639- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- RNA modifications and cancer
- CAR-T cell therapy research
- Herpesvirus Infections and Treatments
- Nutrition and Health in Aging
- Inflammasome and immune disorders
- Poxvirus research and outbreaks
- Lymphoma Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Meningioma and schwannoma management
- Bacillus and Francisella bacterial research
- Cancer Cells and Metastasis
- Anatomy and Medical Technology
- Civil and Geotechnical Engineering Research
- Clinical Nutrition and Gastroenterology
- Advanced Computational Techniques and Applications
- 14-3-3 protein interactions
- Simulation and Modeling Applications
- Cancer Mechanisms and Therapy
- Body Composition Measurement Techniques
Union Hospital
2010-2025
Hunan Provincial People's Hospital
2024-2025
Hunan Normal University
2024-2025
Nanjing Drum Tower Hospital
2024
Huazhong University of Science and Technology
2010-2024
Nanjing Medical University
2021-2024
Central South University
2024
Capital Medical University
2014-2024
Tianjin Medical University
2012-2023
Wuhan Union Hospital
2023
Background: The management of various central nervous system (CNS) disorders has been challenging, due to highly compact blood-brain barrier (BBB) impedes the access most pharmacological agents brain. Among multiple strategies proposed circumvent this challenge, intranasal delivery route sparked great interest for brain targeting in past decades. aim study was apply scientometric method estimate current status and future trends field from a holistic perspective. Methods: All relevant...
Background: Ferroptosis is an iron-dependent programmed cell death process. Recent studies have found that ferroptosis inducers hold promising potential in the treatment of lung adenocarcinoma (LUAD). However, comprehensive analysis about prognostic value ferroptosis-related genes LUAD remains to be elucidated. Methods: The RNA sequencing data and corresponding clinical information were obtained from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. A total 259 extracted...
Background Glioma is a lethal primary tumor of central nervous system. Ferroptosis newly identified form necrotic cell death. Triggering ferroptosis has shown potential to eliminate aggressive tumors. GPX7, member glutathione peroxidase family (GPXs), been described participate in oxidative stress and tumorigenesis. However, the biological functions GPX7 glioma are still unknown. Methods Bioinformatics method was used assess prognostic role glioma. CCK8, wound healing, transwell apoptosis...
Abstract Background The correlation between calf circumference（CC）and sarcopenia has been demonstrated, but the maximum muscle circumference (CMMC) measured by ultrasound and not reported. We aims to construct a predictive model for based on CMMC in hospitalized older patients. Methods This was retrospective controlled study of patients > 60 years age geriatric department Hunan Provincial People’s Hospital. were thoroughly evaluated questionnaires, laboratory, examinations, including...
There is an urgent need to identify novel potential therapeutic targets for diagnosis and treatment of glioma, a common primary tumor in brain, due its high‑level invasiveness. Long non‑coding RNA (lncRNA) LINC00473 has been reported as potentially critical regulators various types cancer tumorigenesis. However, the effects on glioma cells unclear. The present study aimed investigate clinical significance, mechanism LINC00437 In study, was significantly increased tissues cell models,...
The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and underlying mechanisms. I/R model was established using C57BL/J6 mice. Haematoxylin eosin staining performed observe tissues. Commercial kits were used measure levels serum enzymes inflammatory factors. vitro by hypoxia/reoxygenation method H9C2 cells. A dual luciferase reporter assay confirm binding sirtuin 1 (SIRT1). Cell pyroptosis determined flow cytometry. Reverse...
Abstract Aims This study aims to explore the molecular mechanism of circular RNAs' (circRNAs) potential involvement in myocardial ischaemia–reperfusion injury (MIRI). Methods and results Differently expressed genes infarction (MI) were identified by screening GEO database. Serum was collected from MI patients healthy volunteers ( n = 5 for each group). AC16 cells cultured exposed hypoxia/reperfusion (H/R) treatment cell experiments. Then candidate validated human serum H/R model....
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. BCL2 apoptosis regulator (BCL2) and marker proliferation Ki-67 (Ki-67) are established prognostic markers, which have traditionally been assessed separately in DLBCL. However, no studies evaluated value combination index. Thus, present study aimed to analyze these two markers. Immunohistochemical analysis was used assess expression 274 cases The BCL2/Ki-67 index demonstrated a significant association with...
This paper examines the application of 3D printing technology in endoscopic endonasal approach for treatment macroadenomas.We have retrospectively analysed 20 patients who diagnosed with macroadenoma underwent transsphenoidal surgery Wuhan Union hospital from January 2017 to May 2017. Among patients, 10 received service preoperatively. The data processing and clinical result were recorded further evaluation.The had a successful printed model their tumors, it shows anatomy sphenoid sinus,...
To investigate the role of tyrosine 23 (Tyr23) phosphorylation Annexin A2 (Anxa2) in regulating proliferation and invasion human breast cancer SK-BR-3 cells.A panel lentivirus plasmids expressing Anxa2-wide type (Ana2-WT), Anxa2-Y23A, Anxa2-Y23D was generated infected with cells. The monoclonal strains were screened. expression Anxa2-WT, determined by Western blot analysis. ability cells to proliferate detected through an MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide]...
Sinomenine is a pure alkaloid that can be isolated from the root of <em>Sinomenium acutum</em> and has been found to exert anti‑inflammatory immunosuppressive effects. The present study investigated effects sinomenine hydrochloride (SIN) on inflammation gut microbiota composition in colon mouse models dextran sulfate sodium (DSS)‑induced colitis. DSS‑induced mice colitis was established by treating with drinking water containing 3% (w/v) DSS for 7 days. disease activity index each calculated...
Background: Gliomas are the most common intracranial malignant neoplasms and have high recurrence mortality rates. Recent literatures reported that centromere protein N (CENPN) participates in tumor development. However, clinicopathologic significance biological functions of CENPN glioma still unclear. Methods: Clinicopathologic data gene expression profiles cases downloaded from The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) databases were utilized to determine associations between...
Triple negative breast cancer (TNBC) is characterized by poor prognosis and a lack of effective therapeutic agents owing to the absence biomarkers. A high abundance tumor-infiltrating regulatory T cells (Tregs) was associated with worse in malignant disease. Exploring association between Treg cell infiltration TNBC will provide new insights for understanding immunosuppression may pave way developing novel immune-based treatments. Patients from TCGA were divided into Treg-high (Treg-H)...
Annexin A2 (ANXA2) has been found to be involved in cancer proliferation, metastasis and prognosis; however, its exact role nasopharyngeal carcinoma (NPC) radioresistance remains unknown. We that ANXA2 expression was correlated with prognosis NPC patients, longer overall survival patients low than those high expression. knockdown increased the radiosensitivity radioresistant cells, overexpression decreased cells. Knocking-down irradiation-induced apoptosis of induced G2/M phase arrest cells...
Human papillomavirus (HPV) is one of the most common sexually transmitted infectious pathogens. Persistent infection has been linked to cancer development, in particular cervical cancer. This study aims investigate epidemiology HPV women Inner Mongolia China and dissect disparities between Han Mongolian ethnic populations. Cervical cell samples from 5655 (17‐68 years old) were collected during routine gynecologic examination. was established using GenoArray kit detecting 21 genotypes. The...
Abstract The application of 3D printing in planning endoscopic endonasal transsphenoidal surgery is illustrated based on the analysis patients with intracranial skull base diseases who received treatment our department. Cranial computed tomography/magnetic resonance imaging data are attained preoperatively, and three-dimensional reconstruction performed using MIMICS (Materialise, Leuven, Belgium). Models printed a printer before surgery. models clearly demonstrate morphologies spatial...