A5050281330- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- RNA modifications and cancer
- MicroRNA in disease regulation
- Infectious Diseases and Tuberculosis
- Immune cells in cancer
- Circular RNAs in diseases
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- Brain Metastases and Treatment
- RNA Interference and Gene Delivery
- Amoebic Infections and Treatments
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Wound Healing and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Mechanisms and Therapy
- Protein Tyrosine Phosphatases
- Autophagy in Disease and Therapy
- Microscopic Colitis
- Sarcoidosis and Beryllium Toxicity Research
- Extracellular vesicles in disease
Wuhan Union Hospital
2021-2025
Huazhong University of Science and Technology
2019-2025
Union Hospital
2019-2025
Union Hospital
2023-2025
Sun Yat-sen University
2023-2024
Sun Yat-sen University Cancer Center
2023-2024
Xi'an Medical University
2021-2024
State Key Laboratory of Oncology in South China
2023
Third Affiliated Hospital of Zhengzhou University
2021
Yuhuangding Hospital
2017-2020
Abstract Tumor‐associated macrophage (TAM) infiltration facilitates glioma malignancy, but the underlying mechanisms remain unclear. Herein, it is reported that TAMs secrete exosomal LINC01232 to induce tumor immune escape. Mechanistically, found directly bind E2F2 and promote entry into nucleus; two synergistically promots transcription of NBR1. The increase in binding between NBR1 ubiquitinating MHC‐I protein through ubiquitin domain causes an degradation autophagolysosomes a decrease...
Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are implicated in the regulation of tumor cell ferroptosis. However, prognostic value ferroptosis-related lncRNAs has never been comprehensively explored glioma. In this study, transcriptomic data and clinical information glioma patients were downloaded from TCGA, CGGA Rembrandt databases. We identified 24 lncRNAs, 15 which (SNAI3-AS1, GDNF-AS1, WDFY3-AS2, CPB2-AS1, WAC-AS1, SLC25A21-AS1, ARHGEF26-AS1, LINC00641, LINC00844,...
Abstract It is critical to understand factors associated with nasopharyngeal carcinoma (NPC) metastasis. To track the evolutionary route of metastasis, here we perform an integrative genomic analysis 163 matched blood and primary, regional lymph node metastasis distant tumour samples, combined single-cell RNA-seq on 11 samples from two patients. The mutation burden, gene frequency, signature, copy number frequency are similar between metastatic tumours primary tumours. There distinct routes...
Background Advanced triple-negative breast cancer (TNBC) is prone to brain metastasis (BrM). The precise molecular mechanism responsible for this phenomenon has not yet been completely established, so it vital comprehend the behind it. Methods protein chip analysis was conducted identify any abnormal UBE2T expression in TNBC, especially BrM. Here, we used public databases and bioinformatics as well clinical samples from different cohorts investigate interrelationship between...
Breast cancer that is accompanied by a high level of cyclin E expression usually exhibits poor prognosis and clinical outcome. Several factors are known to regulate the during cell cycle progression. The transcription factor DEC1 (also as STRA13 SHARP2) plays an important role in proliferation apoptosis. Nevertheless, mechanism its poorly understood. In this study, using breast lines MCF-7 T47D, we showed could inhibit progression cells independently transcriptional activity. cycle-dependent...
Glioblastoma (GBM) is the most lethal primary tumor of central nervous system, with its resistance to treatment posing significant challenges. This study aims develop a comprehensive prognostic model identify biomarkers associated temozolomide (TMZ) resistance. We employed multifaceted approach, combining differential expression and univariate Cox regression analyses screen for TMZ resistance-related differentially expressed genes (TMZR-RDEGs) in GBM. Using LASSO analysis, we selected 12...
ADAM12, part of the adisintegrin and metalloproteases (ADAMs) family, has been widely reported in recent years to be associated with various malignant tumor behaviors, including migration, invasion, treatment resistance. However, its role at pan-cancer level remains insufficiently characterized. In this study, data were utilized elucidate expression patterns, prognostic significance, potential roles ADAM12 within immune microenvironment. An in-depth analysis gliomas was also conducted. Our...
Glioblastoma (GBM) is the most lethal type of brain tumor. Recent studies have indicated that cellular senescence-targeted therapy a promising approach for cancer treatment. However, underlying mechanisms remain to be clarified. In this study, 101 unique combinations 10 machine learning algorithms were used construct prognostic models based on senescence-related genes (CSRGs). We developed CSRG signature (CSRGS) using exhibited optimal performance. GBM samples stratified into high- and...
There is an urgent need to identify novel potential therapeutic targets for diagnosis and treatment of glioma, a common primary tumor in brain, due its high‑level invasiveness. Long non‑coding RNA (lncRNA) LINC00473 has been reported as potentially critical regulators various types cancer tumorigenesis. However, the effects on glioma cells unclear. The present study aimed investigate clinical significance, mechanism LINC00437 In study, was significantly increased tissues cell models,...
MicroRNAs (miRNAs) are important regulators that involved in the development of different types tumors. MicroRNA-200c (miR-200c) has been characterized as a tumor suppressor or oncogene cancers. However, role miR-200c pituitary tumorigenesis remains unknown. We observed was overexpressed adenoma cell lines. transfected inhibitor into cells (MMQ line) to inhibit expression and found percentage apoptotic MMQ increased. Using bioinformatics analyses, we predicted gene PTEN targeted by miR-200c,...
As an inflammatory form of programmed cell death, pyroptosis has been well established to be associated with tumorigenesis and tumor immune microenvironment. In this paper, we aimed at the construction a pyroptosis-related gene prognostic index (PRGPI) for predicting prognosis guiding individualized immunotherapy in glioma patients.Pyroptosis-related genes (PRGs) were identified based on detailed review published literatures. The transcriptome data clinical information patients obtained from...
Abstract Glioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for various metabolites and ions. They play a crucial role in regulating metabolism functions cells immune within microenvironment, making them promising target cancer therapy. Through multidimensional data...
Abstract Background Emerging evidences have indicated that the aberrant liquid–liquid phase separation (LLPS) leads to dysfunction of biomolecular condensates, thereby contributing tumorigenesis and progression. Nevertheless, it remains unclear whether or how LLPS specific molecules affects prognosis tumor immune microenvironment (TIME) patients with lower-grade glioma (LGG). Methods We integrated transcriptome information 3585 LLPS-related genes comprehensively evaluate patterns 423 LGG in...
POLD4 plays a crucial part in the complex machinery of DNA replication and repair as vital component polymerase delta complex. In this research, we obtained original information from various publicly available databases. Using blend R programming internet resources, initiated an extensive examination into correlation between expression elements cancers. addition, performed knockdown experiments glioma cell lines to authenticate its significant impact. We discovered that is upregulated...
Abstract Aims To evaluate the clinical significance of coatomer protein complex subunit beta 2 ( COPB2 ) in patients with glioma using a bioinformatics analysis. Methods Oncomine, GEO, and The Cancer Genome Atlas databases were used to examine transcript levels tissues. Gene expression profiles information from low‐grade glioblastoma (GBM) projects analyzed for associations between clinicopathologic characteristics. Kaplan‐Meier survival Cox regression analyses set enrichment analysis (GSEA)...
The proliferation and migration of Schwann cells contribute to axonal outgrowth functional recovery after peripheral nerve injury. Previously, several microRNAs were abnormally expressed injury they played important roles in regeneration. However, the role underlying mechanism miR-34a remain largely unknown. levels contactin-2 (CNTN2) detected by quantitative real-time PCR. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide transwell assays used examine cell migration,...
Glioma is the most common malignant brain tumor in adults, with its tumor-promoting immune microenvironment always being intricate to handle with. Amounts of evidence has accumulated suggest that alternative splicing (AS) related microenvironment. However, comprehensive analysis immune-related AS events and their clinical significance are still lacking glioma.AS transcriptome data 653 glioma patients were downloaded online. ssGSEA was performed on divided them into low, medium high cell...
Tuberculosis combined with brucellosis is a very rare condition. Overlapping clinical presentation and laboratory parameters of tuberculosis may lead to misdiagnosis or delayed diagnosis the The current study presents case 45‑year‑old male symptoms lower back pain, non‑tender swelling in right flank, intermittent hyperpyrexia, sweating, body aches numbness weakness limb. A lumbar computed tomograph (CT) scan magnetic resonance imaging indicated vertebral destruction formation sequestra...
A correct preoperative diagnosis is essential for the treatment and prognosis of necrotic glioblastoma brain abscess, but differentiation between them remains challenging. We constructed a diagnostic prediction model with good performance enhanced clinical applicability based on data from 86 patients 32 abscess that were diagnosed January 2012 2020. The values three regions interest contrast-enhanced T1 weighted images (including whole tumor, brain-tumor interface, an amalgamation both...