A5059545505- Hearing, Cochlea, Tinnitus, Genetics
- Connexins and lens biology
- Hearing Loss and Rehabilitation
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Vestibular and auditory disorders
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Plant Pathogens and Fungal Diseases
- Ear Surgery and Otitis Media
- Ion channel regulation and function
- Bioactive Natural Diterpenoids Research
- Plant Pathogens and Resistance
- Marine animal studies overview
- Toxin Mechanisms and Immunotoxins
- RNA regulation and disease
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Plant Disease Management Techniques
- Immune Response and Inflammation
- Thyroid Disorders and Treatments
- Plant and Fungal Interactions Research
- Antioxidant Activity and Oxidative Stress
- Microbial Inactivation Methods
- Traditional and Medicinal Uses of Annonaceae
University of Electronic Science and Technology of China
2025
Sichuan Cancer Hospital
2025
Huazhong University of Science and Technology
2009-2024
Union Hospital
2017-2024
Yunnan Agricultural University
2022-2024
Shandong Agricultural University
2020-2023
University of Colorado Anschutz Medical Campus
2021-2022
Weatherford College
2022
Xinxiang Medical University
2021
Westlake University
2019
Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are implicated in the regulation of tumor cell ferroptosis. However, prognostic value ferroptosis-related lncRNAs has never been comprehensively explored glioma. In this study, transcriptomic data and clinical information glioma patients were downloaded from TCGA, CGGA Rembrandt databases. We identified 24 lncRNAs, 15 which (SNAI3-AS1, GDNF-AS1, WDFY3-AS2, CPB2-AS1, WAC-AS1, SLC25A21-AS1, ARHGEF26-AS1, LINC00641, LINC00844,...
Abstract Background Ferroptosis has been linked to tumor progression and resistance antineoplastic therapy. Long noncoding RNA (lncRNA) exerts a regulatory role in various biological processes of cells, while the function molecular mechanism lncRNA ferroptosis are yet be clarified glioma. Methods Both gain-of-function loss-of-function experiments were employed investigate effects SNAI3-AS1 on tumorigenesis susceptibility glioma vitro vivo. Bioinformatics analysis, Bisulfite sequencing PCR,...
Plasmodiophora brassicae is an ever-increasing threat to cruciferous crop production worldwide. This study investigated the impact of pre-soil fumigation with ammonium bicarbonate (N) and lime (NB) manage clubroot disease in Chinese cabbage through 16S rRNA gene amplification sequencing. We found that soil N NB suppressed incidence by reducing acidity population P. rhizosphere. Minimum maximum relative control effect about 74.68 66.28% were achieved greenhouse field experiments,...
Thirteen new grayanane diterpenoids (1–13), a dimeric diterpenoid, bimollfoliagein A (14), and 15 known analogues (15–29) were isolated from the leaves of Rhododendron molle. The structures compounds (1–14) determined by extensive spectroscopic data interpretation. absolute configurations 1–3, 7, 8, 16, 18, 24 defined single-crystal X-ray diffraction analysis. Mollfoliagein (1) represents first example 2,3:11,16-diepoxy featuring cis/trans/cis/cis/trans-fused 3/5/7/6/5/5 hexacyclic ring...
Potato late blight is a severe and highly epidemic disease caused by Phytophthora infestans that can affect all parts of the plant. This study mainly screened antagonistic strains for good control potato identified strain SDTB038 as Bacillus velezensis according to its morphological chemical properties 16S rRNA, gyrA, gyrB gene sequences. achieved in greenhouses fields promoted plant growth. Two-year field trials (2018 2019) showed B. be used reduce food losses blight, achieving reductions...
Fusarium crown and root rot of tomato is a soilborne diseases that has brought serious harm economic losses to production in facilities recent years. The disease been reported more than 30 countries worldwide, but there are few reports on its biological control. A Bacillus velezensis strain SDTB038 with biocontrol effects was isolated identified previous study considered one the most important PGPRs. Seven secondary metabolite biosynthesis gene clusters were found by whole genome sequencing,...
Sudden sensorineural hearing loss (SSNHL) is a common emergency in the world. Increasing evidence of imbalance oxidant–antioxidant were found SSNHL patients. Steroids combined with antioxidants may be potential strategy for treatment SSNHL. In cochlear explant experiment, we that N-acetylcysteine (NAC) dexamethasone can effectively protect hair cells from oxidative stress when they both at ineffective concentrations alone. A clinic trial was designed to explore whether oral NAC intratympanic...
Abstract The GJB2 gene, encoding Connexin26 (Cx26), is one of the most common causes inherited deafness. Clinically, mutations in cause congenital deafness or late‐onset progressive hearing loss. Recently, it has been reported that Cx26 haploid deficiency accelerates development age‐related loss (ARHL). However, roles cochlear function aged animals remain unclear. In this study, we revealed expression was significantly reduced cochleae mice, and further explored underlying molecular...
Abstract Mutations in the GJB2 gene (encoding Connexin26(Cx26)) are most common cause of hereditary deafness, accounting for about a quarter all cases. Sensory epithelial damage is considered to be one main causes deafness caused by mutation. Dexamethasone (DEX) widely used treatment variety inner ear diseases including sudden sensorineural hearing loss (SSNHL), noise-induced (NIHL), and ototoxic drugs. Whether DEX has direct therapeutic effect on especially -related remains unclear. In this...
Clubroot caused by Plasmodiophora brassicae is an economically important soilborne disease of Chinese cabbage worldwide. Integrated biological control through crop rotation considered a good management approach to suppress the incidence diseases. In this study, we evaluated effect marigold plant (root exudates, crude extract, and powder) on germination death resting spores P. in vitro assays. Additionally, also performed 16S high throughput sequencing, investigate impact marigold-Chinese...
The macrophage-related immune response is an important component of the cochlear to different exogenous stresses, including noise, ototoxic antibiotics, toxins, or viral infection. However, role in hereditary deafness caused by genetic mutations rarely explored. GJB2 , encoding connexin 26 (Cx26), most common gene deafness. In this study, two distinct Cx26-null mouse models were established investigate types and underlying mechanisms responses. a systemic model, macrophage recruitment was...
Significance: The relationship between lipid disturbances and renal diseases has been studied for several decades, it is well recognized that when the balance of uptake, synthesis, oxidation, outflow disrupted, lipids will undergo be sequestrated as droplets, generate toxic metabolites, cause nephrotoxicity in diverse diseases. Recent Advances: During disorders, redox signaling a pivotal event promoting or resulting from disorders. Accordingly, vicious cycle dysregulation could developed,...
Cerebral ischemia triggers vascular dementia (VD), which is characterized by memory loss, cognitive deficits, and injury in the brain. Puerarin (Pur) represents major isoflavone glycoside of Radix Puerariae, with verified neuroprotective activity cardiovascular protective effects. However, whether Pur ameliorates impairment rats permanent occlusion bilateral common carotid arteries (BCCAO) remains unknown. This work aimed to assess Pur’s effects on BCCAO-induced VD dissect underlying...
Abstract Background Emerging evidences have indicated that the aberrant liquid–liquid phase separation (LLPS) leads to dysfunction of biomolecular condensates, thereby contributing tumorigenesis and progression. Nevertheless, it remains unclear whether or how LLPS specific molecules affects prognosis tumor immune microenvironment (TIME) patients with lower-grade glioma (LGG). Methods We integrated transcriptome information 3585 LLPS-related genes comprehensively evaluate patterns 423 LGG in...
Mutations in the GJB2 gene encoding connexin26 (Cx26) protein are one of most common causes hereditary deafness. Previous studies have found that different Cx26-null mouse models severe hearing loss and deformity organ Corti (OC) as well a reduction microtubules pillar cells (PCs). To explore underlying mechanism OC caused by Cx26 downregulation further, we established knockdown (KD) at postnatal days (P)0 P8. The actin filaments contained mice P0 KD group were reduced 54.85% vinculin was...
Genetic testing is the gold standard for exploring etiology of congenital hearing loss. Here, we enrolled 137 Chinese patients with loss to describe molecular epidemiology by using 127 gene panel or 159 variant testing. Sixty-three deaf children received testing, while seventy-four By use more mutant genes and variants were identified. The most frequent GJB2, SLC26A4, MYO15A, CDH23, OTOF. analyzing who found that 51 carried which not included in Therefore, a large number would be...