A5101423923- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- Pregnancy and preeclampsia studies
- Renal Diseases and Glomerulopathies
- Hepatitis B Virus Studies
- Long-Term Effects of COVID-19
- Hepatitis C virus research
- Autophagy in Disease and Therapy
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal Respiratory Health Research
- Estrogen and related hormone effects
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Congenital Diaphragmatic Hernia Studies
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Nephrotoxicity and Medicinal Plants
- Chronic Kidney Disease and Diabetes
- Ferroptosis and cancer prognosis
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Cervical Cancer and HPV Research
- Tracheal and airway disorders
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2023-2025
Huazhong University of Science and Technology
2015-2024
Children's Hospital of Chongqing Medical University
2008-2024
Chongqing Medical University
2008-2024
Central South University
2022-2024
China Pharmaceutical University
2024
Union Hospital
2006-2024
Third Affiliated Hospital of Sun Yat-sen University
2017-2024
Sun Yat-sen University
2017-2024
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics facilitate development novel therapeutics. In this study, we report findings from lungs lymphatic organs 12 decedents-findings that evaluated histopathological changes, immune cell signature inflammatory factor expression in lungs, spleen lymph nodes. Here show major pulmonary alterations included diffuse alveolar damage, interstitial fibrosis exudative...
Abstract Background Renal cell carcinoma (RCC) survival has improved due to recent developments in RCC treatment. Therefore, other co-morbid conditions may have a more critical role. This study aims explore the common causes of death patients with improve management and RCC. Method We used Surveillance, Epidemiology, End Results (SEER) (1992–2018) database get calculated percentage total deaths six kinds cause (COD) cumulative incidence for each selected over time. The joinpoint regression...
Mouse double minute 2 (MDM2) and vascular endothelial growth factor (VEGF) are important molecules involved in tumor progression. We researched potential inhibitors that simultaneously target MDM2 VEGF. In our recent study involving the performance of high-throughput screening with a fluorescence polarization assay, gossypol was identified as one top hits inhibit protein-RNA binding activity. Because is an RNA-binding protein its targets include VEGF mRNA, we investigated whether has...
ABSTRACT Contact-dependent growth inhibition (CDI) systems encode CdiA effectors, which bind to specific receptors on neighboring bacteria and deliver C-terminal toxin domains suppress target cell growth. Two classes of effectors that distinct surface have been identified, but the molecular basis receptor specificity is not understood. Alignment BamA-specific EC93 from Escherichia coli OmpC-specific EC536 E. 536 suggests receptor-binding domain resides within a central region varies between...
G-protein-coupled estrogen receptor (GPER) was found to promote non-small cell lung cancer (NSCLC) by estrogen, indicating the potential necessity of inhibiting GPER a selective antagonist. This study performed elucidate function GPER-selective inhibitor G15 in NSCLC development. Cytoplasmic (cGPER) and nuclear (nGPER) were detected immunohistochemical analysis samples. The relation β (ERβ) expression correlation between GPER, ERβ, clinical factors analyzed. effects activating analyzed...
In non-small cell lung cancer (NSCLC), estrogen (E2) significantly promotes NSCLC growth via receptor beta (ERβ). Discovery and elucidation of the mechanism underlying estrogen-promoted progression is critical for effective preventive interventions. IL6 has been demonstrated to be involved in development, metastasis several cancers overexpression associated with poor prognosis NSCLC. However, exact role played by progress remain unknown. Here, we evaluated expression biological effects cells...
The onset and progression of non-alcoholic fatty liver disease (NAFLD) remains unclear, but short-chain acids (SCFAs) in circulation may participate its pathogenesis by acting as inflammation inhibitors. aim this retrospective study was to investigate plasma concentrations general SCFAs healthy individuals patients with distinct stages NAFLD. Three main (including acetate, propionate butyrate) were analyzed gas chromatography. TNF-α concentration measured ELISA. One-way ANOVA, Spearman's...
Abstract Acute-on-chronic liver failure is a distinct clinical syndrome characterized by dysregulated immune response and extensive hepatocyte death without satisfactory therapies. As cytoplasmic degradative quality-control process, autophagy was implicated in maintaining intracellular homeostasis, decreased hepatic found many diseases contributes to disease pathogenesis. Previously, we identified the therapeutic potential of mesenchymal stem cells (MSCs) ACLF patients; however, intrinsic...
Background: Hypoxia-inducible factor-1α (HIF-1α) induces the expression of glycolysis-related genes, which plays a direct and key role in Warburg effect. In recent study, honokiol (HNK) was identified as one potential agents that inhibited HIF-1α signaling pathway. Because HIF- 1α pathway is closely associated with glycolysis, we investigated whether HNK HIF-1α-mediated glycolysis. Methods: The effects on glycolysis other genes' expressions, cancer cells apoptosis tumor growth were studied...
Z-DNA-binding protein 1 (ZBP1) is an innate sensor of influenza A virus (IAV) that participates in IAV-induced programmed cell death. Nevertheless, little known about the upstream signaling pathways regulating ZBP1. We found a member tripartite motif (TRIM) family, TRIM34, interacted with ZBP1 to promote its K63-linked polyubiquitination. Using series genetic approaches, we provide vitro and vivo evidence indicating IAV triggered death inflammatory responses via dependent on TRIM34/ZBP1...
The aim of this study was to analyse epigenetic (specifically, DNA methylation) change in testes induced by maternal exposure di-2-(ethylhexyl) phthalate (DEHP) mice. Testicular dysgenesis syndrome foetuses DEHP. High-performance liquid chromatography performed methylation status, and expression levels the methyltransferases were examined quantitative real-time polymerase chain reaction western blotting. DEHP significantly had more than 10% relative increase global also increased...
Triptolide has been shown to exhibit anticancer activity. However, its mechanism of action is not clearly defined. Herein we report a novel signaling pathway, MDM2/Akt, involved in the triptolide. We observed that triptolide inhibits MDM2 expression human breast cancer cells with either wild-type or mutant p53. This inhibition resulted decreased Akt activation. More specifically, interfered interaction between and transcription factor REST increase regulatory subunit PI3-kinase p85...
Ghrelin regulates body weight, food intake, and blood glucose. It also insulin secretion from pancreatic islet cells. LEAP2 is a newly discovered endogenous ligand of the growth hormone secretagogue's receptor (GHSR). not only antagonizes stimulation GHSR by ghrelin but inhibits constitutive activation as an inverse agonist. Type 2 diabetes (T2D) patients have endocrine disorders with metabolic imbalance. Plasma levels may be changed in obese T2D patients. However, there no report yet on...
Effective triage of high-risk human papillomavirus (hrHPV)+ women is warranted to avoid unnecessary referral and overtreatment. Molecular tests have recently begun impact cervical intraepithelial neoplasia grade 3 (CIN3) or cancer (CC), termed CIN3+, detection. We find that zinc finger protein 671 methylation (ZNF671m) test has superior performance for CIN3+ detection in all single molecular tests, including HPV16/18 genotyping, paired box gene 1 (PAX1m), ZNF671m, the training set. Using...
Dachshund homolog 1 (DACH1), a key cell fate determination factor, contributes to tumorigenesis, invasion, metastasis of human breast neoplasm. However, the exact molecular mechanisms for anti-tumor roles DACH1 in carcinoma are still lack extensive understanding. Herein, we utilized immunohistochemistry (IHC) staining and public microarray data analysis showing that was higher normal breast, low-grade luminal-type cancer comparison with carcinoma, high-grade basal-like tumors respectively....