A5100764011- Bone Metabolism and Diseases
- Hydraulic and Pneumatic Systems
- Bone health and treatments
- Cytokine Signaling Pathways and Interactions
- Cavitation Phenomena in Pumps
- Water Systems and Optimization
- MicroRNA in disease regulation
- Traditional Chinese Medicine Studies
- Bone Tissue Engineering Materials
- Pediatric health and respiratory diseases
- Diagnosis and treatment of tuberculosis
- HER2/EGFR in Cancer Research
- Estrogen and related hormone effects
- Plasma Applications and Diagnostics
- Peptidase Inhibition and Analysis
- Mathematical Biology Tumor Growth
- Traditional Chinese Medicine Analysis
- Ubiquitin and proteasome pathways
- Growth Hormone and Insulin-like Growth Factors
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Congenital Diaphragmatic Hernia Studies
- Mycobacterium research and diagnosis
- Plasma Diagnostics and Applications
- Trauma Management and Diagnosis
- Respiratory viral infections research
Stomatology Hospital
2025
Kunming Medical University
2025
Huazhong University of Science and Technology
2014-2024
Tongji Hospital
2015-2024
Hainan Medical College Hospital
2024
Beihang University
2023
Wuhan Polytechnic University
2023
University of Chinese Academy of Sciences
2022
Hainan General Hospital
2022
State Key Laboratory of Transducer Technology
2022
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia, pannus formation, and cartilage bone destruction. Nuclear receptor subfamily 1 group D member (NR1D1) functions as transcriptional repressor plays vital role in inflammatory reactions. However, whether NR1D1 involved inflammation joint destruction during the pathogenesis of RA unknown. In this study, we found that expression was increased tissues from patients with decreased Fibroblast-like...
Osteoporosis is a highly prevalent disease which has been major public health problem and considered to be associated with chronic low-grade systemic inflammation oxidative damage. Taxifolin natural flavonoid possesses many pharmacological activities including antioxidant anti-inflammatory. Because flavonoids have confirmed fight osteoporosis promote bone health, the aim of this study was investigate effects taxifolin on formation function osteoclast. In study, we examined osteoclast using...
In this paper, an improved ant lion optimization (IALO) algorithm for parameter identification of hydraulic turbine governing system (HTGS) is proposed. the proposed algorithm, search space explored by first, and then domain searched particle swarm (PSO) in each iteration cycle. A chaotic mutation operation namely Logistics map introduced elite to break out local optimum. operation, a serial-parallel combined method developed increase diversity mutant population. When IALO applied HTGS,...
G-protein-coupled estrogen receptor (GPER) was found to promote non-small cell lung cancer (NSCLC) by estrogen, indicating the potential necessity of inhibiting GPER a selective antagonist. This study performed elucidate function GPER-selective inhibitor G15 in NSCLC development. Cytoplasmic (cGPER) and nuclear (nGPER) were detected immunohistochemical analysis samples. The relation β (ERβ) expression correlation between GPER, ERβ, clinical factors analyzed. effects activating analyzed...
In non-small cell lung cancer (NSCLC), estrogen (E2) significantly promotes NSCLC growth via receptor beta (ERβ). Discovery and elucidation of the mechanism underlying estrogen-promoted progression is critical for effective preventive interventions. IL6 has been demonstrated to be involved in development, metastasis several cancers overexpression associated with poor prognosis NSCLC. However, exact role played by progress remain unknown. Here, we evaluated expression biological effects cells...
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease with poor prognosis. Alpinetin (ALP), derived from Alpinia katsumadai Hayata, has shown potential as therapeutic measure of various diseases. However, the utilization ALP in managing its underlying mechanisms are still not fully understood. A well-established mouse model induced by bleomycin (BLM) was used this study. The antifibrotic effects on histopathologic manifestations expression levels...
Polyetheretherketone (PEEK) has been used in orthopedic surgery for several decades. Numerous methods were invented to alter the properties of PEEK. By adding nanoparticles, fibers, etc., elastic modulus and strength PEEK can be changed meet certain demand. In this study, tantalum (Ta), a promising metal, was introduced modify PEEK, which reinforced with different contents nanoparticles (from 1 wt% 9 wt%). Mechanical biological functions (both vitro vivo) then investigated. The highest...
Abstract Destructive bone diseases caused by osteolysis are increasing in incidence. They characterized an excessive imbalance of osteoclast formation and activation. During osteolysis, the activation nuclear factor‐κB (NF‐κB) mitogen‐activated protein kinase (MAPK) signaling pathways triggered receptor activator NF‐κB ligand (RANKL), inflammatory factors, oxidative stress. Previous studies have indicated that common flavanone glycoside compound hesperetin exhibits anti‐inflammatory...
Osteoarthritis (OA), the most common chronic inflammatory joint disease, is characterized by progressive cartilage degeneration, subchondral bone sclerosis, synovitis, and osteophyte formation. Metformin, a hypoglycemic agent used in treatment of type 2 diabetes, has been evidenced to have anti-inflammatory properties treat OA. It hampers M1 polarization synovial sublining macrophages, which promotes synovitis exacerbates OA, thus lessening loss. In this study, metformin prevented...
Microbial fuel cells (MFCs) convert chemical energy into electricity using microorganisms, offering potential for recovery and environmental remediation. However, slow start-up low power density limit their applications. The microbial community in the inoculant is critical electroactive biofilm (EAB) formation, which directly influences MFC performance. This study established a method to enhance inoculants via long-term storage at room temperature with electron (ES) induction technique,...
<title>Abstract</title> <bold>Background </bold>Fibronectin Leucine-Rich Transmembrane Protein 3 (FLRT3) plays a crucial role in craniofacial development and osteogenic differentiation, yet the regulatory mechanisms of microRNAs (miRNAs) on FLRT3 remain largely unexplored. This study identifies miR-144-3p as miRNA that targets investigates its differentiation. These findings provide foundation for miRNA-based therapeutic strategies diseases contribute to deeper understanding FLRT3’s...
// Sheng Fan 1 , Yongde Liao Changyu Liu Quanfu Huang Huifang Liang 2 Bo Ai Shegnling Fu and Zhou 3 Department of Thoracic Surgery, Tongji Hospital, Medical College, Huazhong University Science Technology, Wuhan 430030, Hubei Province, China Hepatic Surgery Center, Pathology, Correspondence to: Liao, email: liaotjxw@126.com Keywords: non-small cell lung cancer (NSCLC), estrogen, estrogen receptor beta (ERβ), matrix-metalloproteinase (MMP), metastasis Received: September 14, 2016 Accepted:...
The Coronavirus disease 2019 (COVID-19) outbreak has been brought under control through a nationwide effort, and now it become global pandemic the situation seems grim. We summarized measures taken in Wuhan analyzed effects to comprehensively describe factors involved controlling COVID-19 China. In China, several such as lockdown of Wuhan, restriction traffic communities, increasing hospital beds, support from medical staff, epidemic prevention equipment supplies, establishment makeshift...
Tyrosine kinase inhibitor (TKI)-induced thyroid dysfunction is attributed to multiple mechanisms, including immune destruction.Autoimmune disease can be associated with treatment response in cancer immunotherapy trials.The importance of during TKI therapy prognosis unclear.This study analyzes the pattern and significance hypothyroidism therapy.A retrospective cohort adult patients advanced non-thyroid treated available function testing (TFT), at three affiliated academic hospitals from...
Dihydromyricetin (DMY), the main flavonoid component of Ampelopsis grossedentata, possesses pharmacological activities useful for treatment diseases associated with inflammation and oxidative damage. Because osteoclasts are often involved in chronic low-grade systemic damage, we hypothesized that DMY may be an effective osteoclast-related diseases. The effects on osteoclast formation activity were examined vitro. Female C57BL/6 mice ovariectomized to mimic menopause-induced bone loss treated...
Background Currently, tuberculous pleurisy (TP) remains a serious problem affecting global public health, including in China. Our purpose was to comprehensively understand and identify the incidence of TP mainland China between 2005 2018. Methods The data on registered cases from 2018 were acquired National Tuberculosis Information Management System. We analyzed demographics, epidemiology, time-space distribution patients. Then, effects potentially influential factors incidences, such as...