A5002041230- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Hormonal and reproductive studies
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Adrenal Hormones and Disorders
- Neuroscience of respiration and sleep
- Hormonal Regulation and Hypertension
- Vitamin D Research Studies
- Adrenal and Paraganglionic Tumors
- Thyroid and Parathyroid Surgery
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
- Advances in Oncology and Radiotherapy
- Neurological and metabolic disorders
- Bone health and osteoporosis research
- Health Sciences Research and Education
- Radiation Dose and Imaging
- Biochemical Analysis and Sensing Techniques
- Estrogen and related hormone effects
- Nutrition, Genetics, and Disease
- Neuroendocrine regulation and behavior
- Human Health and Disease
Oregon Health & Science University
2015-2025
Montreal Heart Institute
2024
Oregon Clinic
2017-2023
Diabetes Australia
2019-2021
Sint Franciscus Gasthuis
2021
American Thyroid Association
2017
Endocrinology Research Center
1993-2009
Duke Medical Center
2002
Washington DC VA Medical Center
2002
Johns Hopkins University
2002
Background: Thyrotoxicosis has multiple etiologies, manifestations, and potential therapies. Appropriate treatment requires an accurate diagnosis is influenced by coexisting medical conditions patient preference. This document describes evidence-based clinical guidelines for the management of thyrotoxicosis that would be useful to generalist subspecialty physicians others providing care patients with this condition. Methods: The American Thyroid Association (ATA) previously cosponsored were...
To formulate clinical practice guidelines for hormonal replacement in hypopituitarism adults.The participants include an Endocrine Society-appointed Task Force of six experts, a methodologist, and medical writer. The American Association Clinical Chemistry, the Pituitary Society, European Society Endocrinology co-sponsored this guideline.The developed evidence-based guideline using Grading Recommendations, Assessment, Development, Evaluation system to describe strength recommendations...
Recombinant human TSH has been developed to facilitate monitoring for thyroid carcinoma recurrence or persistence without the attendant morbidity of hypothyroidism seen after hormone withdrawal. The objectives this study were compare effect administered recombinant with withdrawal on results radioiodine whole body scanning (WBS) and serum thyroglobulin (Tg) levels. Two hundred twenty-nine adult patients differentiated cancer requiring WBS studied. Radioiodine Tg measurements performed...
Although the use of insulin tolerance test (ITT) for diagnosis adult GH deficiency is well established, diagnostic peak cut-points other commonly used stimulation tests are less clearly established. Despite that fact, majority patients in United States who evaluated do not undergo testing. The aim this study was to evaluate relative utility six different methods testing currently practice and develop each these tests. Thirty-nine (26 male, 13 female) with adult-onset hypothalamic-pituitary...
I. The plan is described of a prospective study the outcome 5,964 pregnancies, with special emphasis on relationship factors in fetal environment to incidence abortions, stillbirths, neonatal mortality and congenital malformations. II. Data are presented overall malformations according sex, race, weight at delivery, maternal age order birth. A. among 5,739 products conception weighing over 500 grams was 7.5%. rate 7.0% infants born alive surviving period, 13.6% antepartum deaths, 23.3%...
Background: Approximately 15% more patients taking levothyroxine (LT4) report impaired quality of life compared to controls. This could be explained by additional diagnoses independently affecting and complicating assignment causation. study sought investigate the underpinnings reduced in hypothyroid provide data for discussion at a symposium addressing hypothyroidism. Methods: An online survey was posted on American Thyroid Association Web site forwarded multiple groups. Respondents were...
The present study was designed to examine the hypothesis that hypothalamic-pituitary-adrenal axis activity as measured by 24-h cortisol production rate (CPR) and plasma levels of free is linked increased body fat in adults, with aging results from CPR. Fifty-four healthy men women volunteers a wide range mass indexes ages underwent measurement CPR isotope dilution gas chromatography-mass spectroscopy, cortisol-binding globulin, pooled plasma, composition, leptin. Cortisol clearance rates...
Thyroid carcinoma requires lifelong monitoring with serum thyroglobulin, radioactive iodine whole body scanning, and other imaging modalities. Levothyroxine (L-T4) withdrawal for thyroglobulin measurement scanning increases these tests' sensitivities but causes hypothyroidism. Recombinant human TSH (rhTSH) enables testing without L-T4 withdrawal.Our objective was to examine the impact of short-term hypothyroidism on health-related quality life (HRQOL) patients after rhTSH vs. withdrawal.In...
The incidence of cardiovascular malformations has been studied in a large series unselected infants. overall rate was 0.83 per cent, and it varied from 7.7 cent infants who were either stillborn or died within the first month (16 209), to 0.6 survived for more than 1 (see Table I). accuracy these rates is discussed, concluded that they are probably somewhat low. Live-born weighing less 2500 gm. at birth have higher do those birth. This difference statistical significance. A careful...
<h3>Importance</h3> In clinical guidelines, overt and subclinical thyroid dysfunction are mentioned as causal treatable factors for cognitive decline. However, the scientific literature on these associations shows inconsistent findings. <h3>Objective</h3> To assess cross-sectional longitudinal of baseline with function dementia. <h3>Design, Setting, Participants</h3> This multicohort individual participant data analysis assessed 114 267 person-years (median, 1.7-11.3 years) follow-up 525 222...
Many hypothyroid subjects receiving L-thyroxine (L-T4) complain of psychological symptoms or cognitive dysfunction. However, there is limited validated information on these self-reports.Cross-sectional comparison 20 euthyroid and 34 treated subjects, aged 20-45 years, with normal thyroid-stimulating hormone (TSH) levels. Subjects underwent the following measures: Short Form 36 (SF-36); Symptom Checklist 90-Revised (SCL-90-R); Profile Mood States (POMS); tests declarative memory (Paragraph...
One hundred and seven healthy, breast fed infants received 1 mg vitamin K1 either at birth (orally or intramuscularly) with the first feed (orally). Venous blood samples collected in next 24 hours were assayed for plasma K1. In babies given orally birth, peak median concentration (73 ng/ml) occurred four hours. By concentrations had fallen to 23 ng/ml 35 groups feed, respectively; this difference was not, however, significant. Plasma after intramuscular injection exceeded those oral all...
Controversy exists as to whether endogenous cortisol production is associated with visceral obesity and insulin resistance in humans. We therefore quantified clearance rates, abdominal fat depots, sensitivity, adipocyte gene expression a cohort of 24 men. To test the relationships found are consequence rather than cause obesity, eight men from this larger group were studied before after weight loss. Daily rates (CPR), free levels (FC), metabolic (MCR) measured by stable isotope methodology...
The objective of the study was to determine whether subclinical hypothyroidism causes decrements in health status, mood, and/or cognitive function.This a double-blinded, randomized, crossover usual dose l-thyroxine (L-T4) (euthyroid arm) vs. lower L-T4 (subclinical hypothyroid subjects.Nineteen subjects on therapy for primary participated study.Subjects underwent measurements and cognition using validated instruments: Short Form 36, Profile Mood States, tests declarative memory (paragraph...
Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality.Our objective was to determine the association between continuous TSH as well categories total cause-specific mortality in a cohort older men.Data were analyzed from Osteoporotic Fractures Men (MrOS) study, community-dwelling U.S. men aged 65 yr older. A 1587 participants randomly selected for testing included this analysis. free T4 measured at baseline, four defined....
Background: Thyrotropin (TSH)-suppressive doses of levothyroxine (LT4) have adverse effects on bone and cardiac function, but it is unclear whether metabolic function also affected. The objective this study was to determine women receiving TSH-suppressive LT4 alterations in energy expenditure or body composition. Methods: This a cross-sectional comparison between three groups women: 26 chronic doses, 80 replacement 16 untreated euthyroid control women. Subjects underwent measurements resting...
Abstract Background The brain is a critical target organ for thyroid hormone, but it unclear whether variations in function within and near the reference range affect quality of life, mood, or cognition. Methods A total 138 subjects with levothyroxine (L-T4)-treated hypothyroidism normal thyrotropin (TSH) levels underwent measures life (36-Item Short Form Health Survey, Underactive Thyroid-Dependent Quality Life Questionnaire), mood (Profile Mood States, Affective Lability Scale), cognition...
Although commonly performed, data are lacking regarding efficacy and safety of lymph node dissection (LND) for recurrent/persistent papillary thyroid cancer (PTC).Evaluate the morbidity LND in PTC.Retrospective review central or lateral performed persistent/recurrent PTC between January 2004 March 2006.Multidisciplinary clinic with a single surgeon at an academic medical center.Seventy-five patients who underwent 79 persistent/residual PTC. Safety analysis included all resections. Exclusion...
Abstract Excess thyroid hormone is associated with increased bone loss and fracture risk in older women, but few data exist for men. We sought to determine if function independently Data were analyzed from the Osteoporotic Fractures Men (MrOS) study, a cohort of community-dwelling U.S. men aged 65 years older. Using case-cohort design, fasting baseline serum archived at −80°C was assayed thyroid-stimulating (thyrotropin) (TSH) free thyroxine (FT4) 397 confirmed nonspine fracture, including...