A5100458579- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Melanoma and MAPK Pathways
- Immune cells in cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Genomics and Chromatin Dynamics
- Bioinformatics and Genomic Networks
- Atherosclerosis and Cardiovascular Diseases
- melanin and skin pigmentation
- Glioma Diagnosis and Treatment
- Genomics and Phylogenetic Studies
- Adipose Tissue and Metabolism
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Virus-based gene therapy research
- Neurobiology and Insect Physiology Research
- Cancer, Lipids, and Metabolism
- Sulfur-Based Synthesis Techniques
- Cancer-related gene regulation
Third Affiliated Hospital of Harbin Medical University
2014-2025
Houston Methodist
2018-2025
Harbin Medical University
2016-2025
Sun Yat-sen University Cancer Center
2024-2025
Sun Yat-sen University
2024-2025
Cornell University
2019-2024
Qilu Hospital of Shandong University
2018-2024
Shandong University
2024
University of Chinese Academy of Sciences
2016-2024
Methodist Hospital
2019-2024
Abstract RNA velocity provides an approach for inferring cellular state transitions from single-cell sequencing (scRNA-seq) data. Conventional models infer universal kinetics all cells in scRNA-seq experiment, resulting unpredictable performance experiments with multi-stage and/or multi-lineage transition of cell states where the assumption same kinetic rates no longer holds. Here we present cellDancer, a scalable deep neural network that locally infers each its neighbors and then relays...
Smooth muscle cell (SMC) phenotypic switching has been increasingly detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC phenotypes AAD tissues mechanisms driving alterations remain to be identified.
Abstract High deviations resulting from prediction model, gender and population difference have limited age estimation application of DNA methylation markers. Here we identified 2,957 novel age-associated sites ( P < 0.01 R 2 > 0.5) in blood eight pairs Chinese Han female monozygotic twins. Among them, nine (false discovery rate 0.01), along with three other reported sites, were further validated 49 unrelated volunteers ages 20–80 years by Sequenom Massarray. A total 95 CpGs covered...
Recent evidence shows that cyclic GMP-AMP synthase (cGAS)/stimulator of interferon (IFN) genes (STING) signaling is essential for antitumor immunity by inducing the production type I IFN and thus activating both innate adaptive based on gene knockout mouse models. However, extensive detection expression cGAS/STING in human cancer mining roles this pathway have not been performed until now. In study, we revealed four key molecules (cGAS, STING, TANK binding kinase 1 [TBK1], regulatory factor...
Abstract The BIG Data Center at Beijing Institute of Genomics (BIG) the Chinese Academy Sciences provides freely open access to a suite database resources in support worldwide research activities both academia and industry. With vast amounts omics data generated ever-greater scales rates, is continually expanding, updating enriching its core through big-data integration value-added curation, including BioCode (a repository archiving bioinformatics tool codes), BioProject biological project...
Abstract Direct radical additions to terminal alkynes have been widely employed in organic synthesis, providing credible access the anti‐Markovnikov products. Because of Kharasch effect, regioselective control for formation Markovnikov products still remains a great challenge. Herein, we develop transition‐metal‐free, visible light‐mediated addition S‐nucleophiles alkynes, furnishing wide array α‐substituted vinyl sulfones with exclusive regioselectivity. Mechanistic investigations...
The cytotoxicity of the natural ent-kaurene diterpenoid, oridonin, has been extensively studied. However, application oridonin for cancer therapy was hampered primarily by its moderate potency. In this study, a series A-ring modified analogues, and their derivatives bearing various substituents on 14-OH position, were designed, synthesized, evaluated anticancer efficacy. Some significantly more potent than against both drug-sensitive drug-resistant cells. most compound, 13p, 200-fold...
The significance of long non-coding RNAs (lncRNAs) in many biological processes and diseases has gained intense interests over the past several years. However, computational identification lncRNAs a wide range species remains challenging; it requires prior knowledge well-established sequences annotations or species-specific training data, but reality is that only limited number have high-quality annotations.Here we first characterize contrast to protein-coding based on feature relationship...
Ryanodine receptors (RyRs) are a class of giant ion channels with molecular mass over 2.2 mega-Daltons. These mediate calcium signaling in variety cells. Since more than 80% the RyR protein is folded into cytoplasmic assembly and remaining residues form transmembrane domain, it has been hypothesized that activation regulation occur through an as yet uncharacterized long-range allosteric mechanism. Here we report characterization Ca2+-activated open-state RyR1 structure by cryo-electron...
Hydrogel strain sensors have attracted tremendous attention in medical monitoring, flexible wearable devices, and human-machine interfaces. However, traditional hydrogels exhibit isotropic sensing performance based on their structure. Therefore, it is challenging to fabricate a hydrogel with an anisotropic structure similar human tissues for achieving characteristics. Herein, we proposed simple effective method preparing poly(vinyl alcohol) (PVA) conductive hydrogels, which demonstrated...
An emerging body of evidence has recently recognized the coexistence epithelial-mesenchymal transition (EMT) and immune response. However, a systems-level view survey interplay between EMT escape program, their impact on tumor behavior clinical outcome across various types cancer is lacking. Here, we performed comprehensive multi-omics analyses to characterize landscape crosstalk evasion relevance 17 solid cancer. Our study showed presence complex dynamic immunomodulatory shared by...
Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated ageing associated with premature vascular disease and death due to heart attack stroke. In HGPS a mutation in lamin A (progerin) alters nuclear morphology gene expression. Current therapy increases the lifespan of these children only modestly. Thus, greater understanding underlying mechanisms required improve therapy. Endothelial cells (ECs) differentiated from induced pluripotent stem (iPSCs) derived patients exhibit hallmarks...
MutS protein is a mismatch binding that recognizes mispaired and unpaired base(s) in DNA. In this study, we incorporate the protein-based mutation recognition into quartz crystal microbalance (QCM) measurements for DNA single-base substitution 1−4 insertion (or deletion) detection. The method involves immobilization of single-stranded probe on QCM surface, hybridization target to form homoduplex or heteroduplex DNA, finally application recognition. By measuring signal, containing T:G is(are)...
The dioxygen-induced radical oxyphosphorylation of alkenes and alkynes is presented, wherein a P–H bond was activated by molecular oxygen.
Polycomb group proteins are important epigenetic regulators for cell proliferation and differentiation, organ development, as well initiation progression of lethal diseases, including cancer. Upregulated proteins, Enhancer zeste homolog 2 (EZH2), promote proliferation, migration, invasion metastasis cancer cells, self‐renewal stem cells. In our study, we report that EZH2 embryonic ectoderm development (EED) indicate respective direct interaction with androgen receptor (AR). the context...
With good flexibility and biocompatibility, hydrogel-based sensors have been widely used in human motion detection, artificial intelligence, human-machine interface, other fields. Previous research on has focused improving the mechanical properties signal transmission sensitivity. development of smart devices, there is an increasing demand for hydrogel sensor comfort more application functions, such as ultrathin structures recognition functions contact surfaces, which are realized with...
There is a lack of useful biomarkers for predicting the efficacy anti–programmed death-1 (PD-1) therapy advanced gastric and colorectal cancer. To address this issue, in study we investigated correlation between inflammatory marker expression survival patients with Data 111 cancer treated anti–PD-1 regimens were retrospectively analyzed. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR), platelet-to-lymphocyte (PLR), clinical characteristics each patient selected as main...
The soil organic carbon (SOC) of grasslands is a vital component the global cycle. SOC in grassland ecosystems arid and semi-arid regions sensitive to climate change, but dynamic drivers content are still controversial. Grazing main factor affecting contents grasslands; however, response different types grazing intensity remains unclear. Based on Denitrification-Decomposition model field investigations, this study, spatial temporal dynamics its Northern Xinjiang were investigated, various...
A comprehensive understanding of endothelial cell lineage specification will advance cardiovascular regenerative medicine. Recent studies found that unique epigenetic signatures preferentially regulate identity genes. We thus systematically investigate the landscape and identify MECOM to be leading candidate as an regulator. Single-cell RNA-Seq analysis verifies MECOM-positive cells are exclusively enriched in cluster bona fide derived from induced pluripotent stem cells. Our experiments...