A5052295445- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Legume Nitrogen Fixing Symbiosis
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- Plant-Microbe Interactions and Immunity
- Liver Disease Diagnosis and Treatment
- Microbial Community Ecology and Physiology
- MicroRNA in disease regulation
- RNA and protein synthesis mechanisms
- Lung Cancer Treatments and Mutations
- Mycorrhizal Fungi and Plant Interactions
- COVID-19 and Mental Health
- Bioinformatics and Genomic Networks
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 detection and testing
- Molecular Biology Techniques and Applications
- Gene expression and cancer classification
- Soil Carbon and Nitrogen Dynamics
- Fungal Biology and Applications
- Soil and Unsaturated Flow
- Plant and animal studies
- Climate Change and Health Impacts
- Hepatitis B Virus Studies
Chinese Academy of Sciences
2016-2025
Institute of Geology and Geophysics
2020-2025
University of Chinese Academy of Sciences
2011-2025
Shanghai Jiao Tong University
2023-2024
Beijing Institute of Genomics
2015-2024
Jilin Agricultural Science and Technology University
2022-2024
Shanghai Center For Bioinformation Technology
2019-2024
Southwest University of Science and Technology
2024
Ningxia Medical University General Hospital
2024
Lanzhou Jiaotong University
2009-2024
The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a family database resources to support global research in both academia and industry. With explosively accumulated multi-omics data at ever-faster rates, CNCB-NGDC is constantly scaling up updating its core through big archive, curation, integration analysis. In past year, efforts have been made synthesize growing knowledge, particularly single-cell omics precision medicine research, series newly...
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides single access point to 44 resources and >18 million ncRNA from wide range organisms types. now also includes secondary (2D) structure information for >13 sequences, making the world's largest 2D database. The diagrams are displayed using R2DT, new visualization method uses consistent, reproducible recognizable layouts related RNAs. sequence similarity search has been updated with faster interface...
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences, collating information on ncRNA sequences all types from broad range organisms. We have recently added new genome mapping pipeline that identifies genomic locations for in 296 species. also several functional annotations, such as tRNA secondary structures, Gene Ontology and miRNA-target interactions. A quality control mechanism based Rfam family assignments potential contamination, incomplete more. The has become...
RNAcentral is a database of non-coding RNA (ncRNA) sequences that aggregates data from specialised ncRNA resources and provides single entry point for accessing all types organisms. Since its launch in 2014, has integrated twelve new resources, taking the total number collaborating to 22, began importing data, such as modified nucleotides MODOMICS PDB. We created species-specific identifiers refer unique within context species. The website been subject continuous improvements focusing on...
The National Genomics Data Center (NGDC) provides a suite of database resources to support worldwide research activities in both academia and industry. With the rapid advancements higher-throughput lower-cost sequencing technologies accordingly huge volume multi-omics data generated at exponential scales rates, NGDC is continually expanding, updating enriching its core through big integration value-added curation. In past year, efforts for update have been mainly devoted BioProject,...
Long non-coding RNAs (lncRNAs) have significant functions in a wide range of important biological processes. Although the number known human lncRNAs has dramatically increased, they are poorly annotated, posing great challenges for better understanding their functional significance and elucidating complex functioning molecular mechanisms. Here, we present LncBook (http://bigd.big.ac.cn/lncbook), curated knowledgebase that features comprehensive collection systematic curation by multi-omics...
Abstract The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a suite database resources to support worldwide research activities in both academia and industry. With explosive growth multi-omics data, CNCB-NGDC is continually expanding, updating enriching its core through big data deposition, integration translation. In past year, considerable efforts have been devoted 2019nCoVR, newly established resource providing global landscape SARS-CoV-2...
The BIG Data Center at Beijing Institute of Genomics (BIG) the Chinese Academy Sciences provides a suite database resources in support worldwide research activities both academia and industry. With vast amounts multi-omics data generated unprecedented scales rates, is continually expanding, updating enriching its core through big integration value-added curation. Resources with significant updates past year include BioProject (a biological project library), BioSample sample Genome Sequence...
Abstract The BIG Data Center at Beijing Institute of Genomics (BIG) the Chinese Academy Sciences provides freely open access to a suite database resources in support worldwide research activities both academia and industry. With vast amounts omics data generated ever-greater scales rates, is continually expanding, updating enriching its core through big-data integration value-added curation, including BioCode (a repository archiving bioinformatics tool codes), BioProject biological project...
Long non-coding RNAs (lncRNAs) perform a diversity of functions in numerous important biological processes and are implicated many human diseases. In this report we present lncRNAWiki (http://lncrna.big.ac.cn), wiki-based platform that is open-content publicly editable aimed at community-based curation collection information on lncRNAs. Current related databases dependent primarily by experts, making it laborious to annotate the exponentially accumulated lncRNAs, which inevitably requires...
Abstract On January 22, 2020, China National Center for Bioinformation (CNCB) released the 2019 Novel Coronavirus Resource (2019nCoVR), an open-access information resource severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2019nCoVR features a comprehensive integration of sequence and clinical all publicly available SARS-CoV-2 isolates, which are manually curated with value-added annotations quality evaluated by automated in-house pipeline. Of particular note, offers systematic...
The significance of long non-coding RNAs (lncRNAs) in many biological processes and diseases has gained intense interests over the past several years. However, computational identification lncRNAs a wide range species remains challenging; it requires prior knowledge well-established sequences annotations or species-specific training data, but reality is that only limited number have high-quality annotations.Here we first characterize contrast to protein-coding based on feature relationship...
Bumblebees are a diverse group of globally important pollinators in natural ecosystems and for agricultural food production. With both eusocial solitary life-cycle phases, some social parasite species, they especially interesting models to understand evolution, behavior, ecology. Reports many species decline point pathogen transmission, habitat loss, pesticide usage, global climate change, as interconnected causes. These threats bumblebee diversity make our reliance on handful well-studied...
Abstract Expression profiles of long non-coding RNAs (lncRNAs) across diverse biological conditions provide significant insights into their functions, interacting targets as well transcriptional reliability. However, there lacks a comprehensive resource that systematically characterizes the expression landscape human lncRNAs by integrating wide range conditions. Here, we present LncExpDB (https://bigd.big.ac.cn/lncexpdb), an database is devoted to providing lncRNA genes, exploring features...
LncBook, a comprehensive resource of human long non-coding RNAs (lncRNAs), has been used in wide range lncRNA studies across various biological contexts. Here, we present LncBook 2.0 (https://ngdc.cncb.ac.cn/lncbook), with significant updates and enhancements as follows: (i) incorporation 119 722 new transcripts, 9632 genes, gene structure update 21 305 lncRNAs; (ii) characterization conservation features genes 40 vertebrates; (iii) integration lncRNA-encoded small proteins; (iv) enrichment...
The National Genomics Data Center (NGDC), which is a part of the China for Bioinformation (CNCB), offers comprehensive suite database resources to support global scientific community. Amidst unprecedented accumulation multi-omics data, CNCB-NGDC committed continually evolving and updating its core through big data archiving, integrative analysis value-added curation. Over past year, has expanded collaborations with international databases established new subcenters focusing on biodiversity,...
Using DNA microarrays, we generated both mRNA and miRNA expression data from 6 non-small cell lung cancer (NSCLC) tissues their matching normal control adjacent to identify potential markers for diagnostics. We demonstrated that hsa-miR-96 is significantly consistently up-regulated in all NSCLCs. validated this result an independent set of 35 paired tumors tissues, as well sera are collected before surgical resection or chemotherapy, the results suggested may play important role NSCLC...
High-fat diet (HFD)-induced obesity is a risk factor for many metabolic disorders including cardiovascular diseases, diabetes, and fatty liver disease. Although there are accumulating evidences supporting the assumption that regulating gut microbiota as well its status able to mitigate obesity, inner relationship between obesity-related relevant metabolites not defined. In current study, we applied traditional herbal formula Kang Shuai Lao Pian (KSLP) HFD-fed mice evaluated effect against...
ABSTRACT Background Public health workers at the Chinese Centre for Disease Control and Prevention (China CDC) primary care institutes (PHIs) were among main who implemented prevention, control, containment measures. However, their efforts status have not been well documented. We aimed to investigate working conditions of front line public in China during COVID-19 epidemic. Methods Between 18 February 1 March 2020, we conducted an online cross-sectional survey 2,313 CDC 4,004 PHI five...