A5068058046- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Insect and Arachnid Ecology and Behavior
- Insect symbiosis and bacterial influences
- Insect and Pesticide Research
- Plant and animal studies
- Insect Resistance and Genetics
- Malaria Research and Control
- Mosquito-borne diseases and control
- Nuclear Structure and Function
- Chromosomal and Genetic Variations
- Invertebrate Immune Response Mechanisms
- Genomics and Phylogenetic Studies
- Animal Genetics and Reproduction
- Neurobiology and Insect Physiology Research
- Genetics, Bioinformatics, and Biomedical Research
- Salivary Gland Disorders and Functions
- CRISPR and Genetic Engineering
National Research Tomsk State University
2017-2023
Virginia Tech
2019-2022
Institute of Theoretical and Experimental Biophysics
2015
Bumblebees are a diverse group of globally important pollinators in natural ecosystems and for agricultural food production. With both eusocial solitary life-cycle phases, some social parasite species, they especially interesting models to understand evolution, behavior, ecology. Reports many species decline point pathogen transmission, habitat loss, pesticide usage, global climate change, as interconnected causes. These threats bumblebee diversity make our reliance on handful well-studied...
Malaria mosquitoes have had a remarkable stability in the number of chromosomes their karyotype (2n = 6) during 100 million years evolution. Moreover, autosomal arms were assumed to maintain integrity even if associations with each other changed via whole-arm translocations. Here we use high-coverage comparative physical genome mapping three Anopheles species test extent evolutionary conservation chromosomal malaria mosquitoes.In this study, developed map for atroparvus, one dominant vectors...
Lamins interact with the nuclear membrane and chromatin but precise players mechanisms of these interactions are unknown. Here, we tested whether removal CaaX motif from Lamin B disrupts its attachment to affects distribution. We used Drosophila melanogaster LamA25 homozygous mutants that lack box. found mutant was not confined periphery distributed throughout interior, colocalizing chromosomes in salivary gland proventriculus. The peripheral position C, pore complex (NPC), heterochromatin...
Phylogenetic analyses of closely related species mosquitoes are important for better understanding the evolution traits contributing to transmission vector-borne diseases. Six out 41 dominant malaria vectors genus Anopheles in world belong Maculipennis Group, which is subdivided into two Nearctic subgroups (Freeborni and Quadrimaculatus) one Palearctic (Maculipennis) subgroup. Although previous studies considered as ancestral, details about their relationship with subgroup, migration times...
Spatial organization of a chromosome in nucleus is very important biology but many aspects it are still generally unresolved. We focused on tissue-specific features architecture closely related malaria mosquitoes, which have essential inter-specific differences polytene attachments nurse cells. showed that the region responsible for X-chromosome attachment interacts with nuclear lamina stronger cells, then salivary glands cells Anopheles messeae Fall. The inter-tissue were demonstrated more...
Anopheles sacharovi is a dominant malaria vector species in South Europe and the Middle East which has highly plastic behaviour at both adult larval stages. Such plasticity prevented this from eradication by several anti-vector campaigns. The development of new genome-based strategies for control will benefit genome sequencing physical chromosome mapping mosquito. Although cytogenetic photomap chromosomes salivary glands An. been developed, no map suitable available.Mosquitoes study were...
Spatial organization of chromosome territories is important for maintenance genomic stability and regulation gene expression. Recent studies have shown tissue-specific features attachments to the nuclear envelope in various organisms including malaria mosquitoes. However, other spatial characteristics nucleus organization, like volume shape territories, not been studied Anopheles. We conducted a thorough analysis X nucleolus follicular epithelium nurse cells Anopheles atroparvus ovaries...
Abstract Background Understanding the evolutionary relationships between closely related taxa is important for mosquitoes that transmit human diseases. Six out of 41 dominant malaria vectors in world belong to Maculipennis group, which subdivided into two North American subgroups (Freeborni and Quadrimaculatus), one Eurasian (Maculipennis) subgroup. Although previous studies considered Nearctic as ancestral, details about their relationship with Palearctic subgroup, migration times routes...
Abstract Bumblebees are a diverse group of globally important pollinators in natural ecosystems and for agricultural food production. With both eusocial solitary lifecycle phases, some social parasite species, they especially interesting models to understand evolution, behavior, ecology. Reports many species decline point pathogen transmission, habitat loss, pesticide usage, global climate change, as interconnected causes. These threats bumblebee diversity make our reliance on handful...