A5028440222- Genomics and Phylogenetic Studies
- Biomedical Text Mining and Ontologies
- Genomics and Rare Diseases
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Olfactory and Sensory Function Studies
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Advanced Chemical Sensor Technologies
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Nutrition, Genetics, and Disease
- Machine Learning in Bioinformatics
- Molecular Biology Techniques and Applications
- Genetic and phenotypic traits in livestock
- Genomic variations and chromosomal abnormalities
- Cancer Genomics and Diagnostics
- Chromosomal and Genetic Variations
- DNA Repair Mechanisms
- Biochemical Analysis and Sensing Techniques
- Genetic and Kidney Cyst Diseases
- Immune Cell Function and Interaction
- Genetic diversity and population structure
- Skin and Cellular Biology Research
Wellcome Trust
2007-2024
European Bioinformatics Institute
2015-2024
University of Cambridge
2019-2023
Cambridge School
2021-2022
Weizmann Institute of Science
2020
Kawasaki Heavy Industries (Japan)
2016
University of Leicester
2013
National Center for Biotechnology Information
2013
University College London
1998-2007
Clinique Victor Hugo
2007
The expanding number of members in the various human heat shock protein (HSP) families and inconsistencies their nomenclature have often led to confusion. Here, we propose new guidelines for HSP families, HSPH (HSP110), HSPC (HSP90), HSPA (HSP70), DNAJ (HSP40), HSPB (small HSP) as well chaperonin HSPD/E (HSP60/HSP10) CCT (TRiC). is based largely on more consistent assigned by HUGO Gene Nomenclature Committee used National Center Biotechnology Information Entrez database genes. In addition...
The HUGO Gene Nomenclature Committee (HGNC) based at the European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. To date HGNC have assigned over 39,000 gene and, representing an increase of 5000 entries in past two years. As well as increasing size our database, we continued redesigning website http://www.genenames.org modified, updated improved many aspects site including a faster more powerful search, vastly HCOP tool REST service number ways users can...
The homeobox genes are a large and diverse group of genes, many which play important roles in the embryonic development animals. Increasingly, being compared between genomes an attempt to understand evolution animal development. Despite their importance, full diversity human has not previously been described. We have identified all pseudogenes euchromatic regions genome, finding unannotated, incorrectly annotated, unnamed, misnamed or misclassified pseudogenes. describe 300 loci, we divide...
The HUGO Gene Nomenclature Committee (HGNC) based at the European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. Currently HGNC database contains almost 40 000 approved gene symbols, over 19 of which represent protein-coding In addition naming genomic loci we manually curate genes into family sets on shared characteristics such as homology, function or phenotype. We have recently updated our resources introduced new improved visualizations can be seen...
The HUGO Gene Nomenclature Committee (HGNC) based at EMBL's European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 40 000 approved gene in our current database of which 19 for protein-coding Vertebrate (VGNC) was established 2016 assign standardized nomenclature line with vertebrate species that lack their own committees. VGNC initially assigned 15000 genes chimpanzee. We have extended this process other species, naming 14000 cow dog 13...
Abstract The HUGO Gene Nomenclature Committee (HGNC) based at EMBL’s European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 42,000 approved gene in our current database of which 19 000 for protein-coding While we still update placeholder problematic symbols, working towards stabilizing where possible; 2000 disease associated genes now marked as stable symbol reports. All data is available the HGNC website https://www.genenames.org....
Abstract The HUGO Gene Nomenclature Committee (HGNC) assigns unique symbols and names to human genes. HGNC database (www.genenames.org) currently contains over 43 000 approved gene symbols, 19 200 of which are assigned protein-coding genes, 14 pseudogenes nearly 9000 non-coding RNA public website, www.genenames.org, displays all nomenclature within Symbol Reports that contain data curated by advisors links related genomic, clinical, proteomic information. Here, we describe updates our...
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that provides single access point to 44 resources and >18 million ncRNA from wide range organisms types. now also includes secondary (2D) structure information for >13 sequences, making the world's largest 2D database. The diagrams are displayed using R2DT, new visualization method uses consistent, reproducible recognizable layouts related RNAs. sequence similarity search has been updated with faster interface...
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences, collating information on ncRNA sequences all types from broad range organisms. We have recently added new genome mapping pipeline that identifies genomic locations for in 296 species. also several functional annotations, such as tRNA secondary structures, Gene Ontology and miRNA-target interactions. A quality control mechanism based Rfam family assignments potential contamination, incomplete more. The has become...
The Kelch-like (KLHL) gene family encodes a group of proteins that generally possess BTB/POZ domain, BACK and five to six Kelch motifs. BTB domains facilitate protein binding dimerization. domain has no known function yet is functional importance since mutations in this are associated with disease. form tertiary structure β-propellers have role extracellular functions, morphology, other proteins. Presently, 42 KLHL genes been classified by the HUGO Gene Nomenclature Committee (HGNC), they...
The HUGO Gene Nomenclature Committee situated at the European Bioinformatics Institute assigns unique symbols and names to human genes. Since 2011, data within our database has expanded largely owing an increase in naming pseudogenes non-coding RNA genes, we now have >33 500 approved symbols. Our gene families groups also increased nearly 500, with ∼45% of entries associated least one family or group. We redesigned website http://www.genenames.org creating a constant look feel across site...
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, GPX6 (glutathione peroxidases), DIO1, DIO2, DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), SEPHS2 (selenophosphate synthetase...
RNAcentral is a database of non-coding RNA (ncRNA) sequences that aggregates data from specialised ncRNA resources and provides single entry point for accessing all types organisms. Since its launch in 2014, has integrated twelve new resources, taking the total number collaborating to 22, began importing data, such as modified nucleotides MODOMICS PDB. We created species-specific identifiers refer unique within context species. The website been subject continuous improvements focusing on...