A5020641535- Insect Resistance and Genetics
- Mosquito-borne diseases and control
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Genomics and Phylogenetic Studies
- Malaria Research and Control
- Insect symbiosis and bacterial influences
- Plant and animal studies
- Insect-Plant Interactions and Control
- Insect Pest Control Strategies
- Cancer-related molecular mechanisms research
- Plant Virus Research Studies
- Heat shock proteins research
- Estrogen and related hormone effects
- Plant Parasitism and Resistance
- Analytic Number Theory Research
- Entomopathogenic Microorganisms in Pest Control
- Molecular Biology Techniques and Applications
- Vector-borne infectious diseases
- Insect and Pesticide Research
- CRISPR and Genetic Engineering
- Plant Pathogenic Bacteria Studies
- Lepidoptera: Biology and Taxonomy
- Coleoptera Taxonomy and Distribution
- Epigenetics and DNA Methylation
Chongqing Normal University
2016-2025
Vector (United States)
2017-2025
Chongqing University
2004-2025
Institute of Entomology
2017-2025
University of Hong Kong
2025
Beijing Hospital
2025
Shandong University
2005-2024
Weinan Normal University
2009-2024
Beijing Academy of Agricultural and Forestry Sciences
2016-2024
Tongji University
2011-2024
Autosomal dominant mutations of the RNA/DNA binding protein FUS are linked to familial amyotrophic lateral sclerosis (FALS); however, it is not clear how cause neurodegeneration. Using transgenic mice expressing a common FALS-associated mutation (FUS-R521C mice), we found that mutant proteins formed stable complex with WT and interfered normal interactions between histone deacetylase 1 (HDAC1). Consequently, FUS-R521C exhibited evidence DNA damage as well profound dendritic synaptic...
HSP90 proteins are essential molecular chaperones involved in signal transduction, cell cycle control, stress management, and folding, degradation, transport of proteins. have been found a variety organisms suggesting that they ancient conserved. In this study we investigate the nuclear genomes 32 species across all kingdoms organisms, sequences available GenBank, address diversity, evolution, gene structure, conservation nomenclature family genes organisms. Twelve new type HSP90C2 were...
Verticillium dahliae is a phytopathogenic fungal pathogen that causes vascular wilt diseases responsible for considerable decreases in cotton yields. The lignification of cell wall appositions conserved basal defence mechanism the plant innate immune response. However, function laccase defence-induced has not been described. Screening an SSH library resistant cultivar, Jimian20, inoculated with V. revealed gene was strongly induced by pathogen. This phylogenetically related to AtLAC15 and...
Abstract The fall armyworm (FAW), Spodoptera frugiperda , is a destructive pest native to America and has recently become an invasive insect in China. Because of its rapid spread great risks China, understanding FAW genetic background pesticide resistance urgent essential develop effective management strategies. Here, we assembled chromosome-level genome male (SFynMstLFR) compared re-sequencing results the populations from America, Africa, Strain identification 163 individuals collected...
Owing to diverse functionalities and metal binding abilities, proteins have been proven be promising ligands in the synthesis of gold nanoclusters (Au NCs). In this work, we explored β-lactoglobulin (β-Lg), a protein byproduct generated during cheese processing, as biotemplate for fabrication Au NCs by facile green method first time. The as-prepared are water soluble highly fluorescent exhibit high sensitivity selectivity Hg2+ detection aqueous solution. Interestingly, found that...
In this paper, the genera Malayepipona Giordani Soika and Megaodynerus Gusenleitner are newly recorded from China. Seven new species of one described illustrated: namely brunnea Bai, Chen Li, sp. nov., M. flaviclypeata lamellata maculosa nigricans sparsipuncta triangula nov. bimaculus nov.. The clypeata Nguyen Carpenter, 2013 is also A key to known updated.
Abstract Butterfly eyespots represent novel complex traits that display substantial diversity in number and size within across species. Correlative gene expression studies have implicated a large suite of transcription factors, including Distal‐less (Dll), Engrailed (En), Spalt (Sal), eyespot development butterflies, but direct evidence testing the function any these proteins is still missing. Here we show characteristic two‐eyespot pattern wildtype Bicyclus anynana forewings correlated with...
Significance Mutations in special AT-rich sequence-binding protein 2 ( Satb2 ) cause severe intellectual deficiency humans. However, its function brain development is not completely understood. Our study focuses on the of specifying cortical projection neuron fates. We find that, although activates expression some subcerebral neuronal genes, it also inhibits other genes that are expressed neurons. report promotes Fezf2 and Sox5 neurons, turn high-level expression. show mutual regulation...
Exome sequencing studies have identified multiple genes harboring de novo loss-of-function (LoF) variants in individuals with autism spectrum disorders (ASD), including TBR1 , a master regulator of cortical development. We performed ChIP-seq for during mouse neurogenesis and show that TBR1-bound regions are enriched adjacent to ASD genes. were also among differentially expressed Tbr1 knockouts, which together the data, suggests direct transcriptional regulation. Of nine examined, seven...
Abstract Cuticular proteins (CPs) are crucial components of the insect cuticle. Although numerous genes encoding cuticular have been identified in known genomes to date, their functions maintaining body shape and adaptability remain largely unknown. In current study, positional cloning led identification a gene an RR1-type protein, BmorCPR2, highly expressed larval chitin-rich tissues at mulberry leaf-eating stages, which is responsible for silkworm stony mutant. Dazao-stony strain, BmorCPR2...
Highlights•Sp9 promotes striatopallidal MSN progenitor division and differentiation•Sp9 is required for the survival of MSNs•Ascl1 directly regulates Sp9 promoter in vivo•Sp9 Adora2a, P2ry1, Gpr6, Grik3 expression striatumSummaryStriatal medium-sized spiny neurons (MSNs), composed striatonigral neurons, are derived from lateral ganglionic eminence (LGE). We find that transcription factor expressed LGE progenitors generate nearly all striatal MSNs maintained postmitotic MSNs. Sp9-null mice...
UDP-glycosyltransferase (UGT) is an important biotransformation superfamily of enzymes. They catalyze the transfer glycosyl residues from activated nucleotide sugars to acceptor hydrophobic molecules, and function in several physiological processes, including detoxification, olfaction, cuticle formation, pigmentation. The diversity, classification, scaffold location, characteristics, phylogenetics, evolution genes at whole genome level, their association mutations associated with pyrethroid...
Abstract Background Aedes albopictus is naturally infected with Wolbachia spp., maternally transmitted bacteria that influence the reproduction of hosts. However, little known regarding prevalence infection, multiple infection status, and relationship between density dengue outbreaks in different regions. Here, we assessed natural populations Ae. China compared regions similar climates, without either imported or local dengue. Results To explore DNA was detected mosquito samples via PCR...
Our study indicated that systematic inflammation and metabolites might be a pathway linking the gut microbiome with insomnia. These findings provide new insights better understanding of microbiota's role in insomnia as well potential novel microbiome-related etiologies for
Abstract Anopheles sinensis is the main vector of malaria with a wide distribution in China and its adjacent countries. The smoke from burning dried mugwort leaves has been commonly used to repel kill mosquito adults especially southern Chinese provinces. In this study, essential oils collected seven provinces were extracted by steam distillation their chemical compositions analyzed. Among total 56–87 constituents confirmed GC–MS analyses, four compounds, eucalyptol, β-caryophyllene, phytol...
Gene drives are alleles that can bias the inheritance of specific traits in target populations for purpose modification or suppression. Here, we construct a homing suppression drive major urban malaria vector Anopheles stephensi targeting female-specific exon doublesex, incorporating two gRNAs and nanos-Cas9 to reduce functional resistance improve female heterozygote fitness. Our results show was recessive sterile both females males, with various intersex phenotypes homozygotes. Both male...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) is an inherited small-vessel disease caused by mutations in NOTCH3. Although CADASIL cases have been identified worldwide, the data from mainland China are still limited.To identify NOTCH3 analyse clinical MRI findings a large series of patients China.Direct sequencing and/or skin or sural nerve biopsies were performed on 48 unrelated suspected Chinese descent. The manifestations features...
Anopheles sinensis is the most important vector of malaria in Southeast Asia, including China. Currently, effective measure to prevent transmission relies on control through use insecticides, primarily pyrethroids. Extensive insecticides poses strong selection pressure mosquito populations for resistance. Resistance can arise due mutations insecticide target site (target resistance), which case pyrethroids para-type sodium channel gene, and/or catabolism by detoxification enzymes before it...