Matthew W. State
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
- Obsessive-Compulsive Spectrum Disorders
- Genomics and Rare Diseases
- Genomics and Chromatin Dynamics
- Genetic Associations and Epidemiology
- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Chromosomal and Genetic Variations
- Bioinformatics and Genomic Networks
- Virology and Viral Diseases
- Trypanosoma species research and implications
- RNA modifications and cancer
- Genetic Syndromes and Imprinting
- Tryptophan and brain disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- CRISPR and Genetic Engineering
- Moyamoya disease diagnosis and treatment
- Child Nutrition and Feeding Issues
- Williams Syndrome Research
- Health, Environment, Cognitive Aging
- Cellular transport and secretion
- RNA Research and Splicing
University of California, San Francisco
2016-2025
Spitalul Clinic Colentina
2023-2025
Carol Davila University of Medicine and Pharmacy
2023-2025
Langley Porter Psychiatric Hospital and Clinics
2014-2023
Quantitative BioSciences
2018-2023
Universidad Católica de Santa Fe
2023
Butler Hospital
2022
Hospital General Universitario Gregorio Marañón
2022
University of North Carolina at Chapel Hill
2021
University of Miami
2021
Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which genetic underpinnings these diseases differ or is unknown. Gandal et al. performed meta-analyses transcriptomic covering five major disorders and compared cases controls identify coexpressed gene modules. From this, they found that some share global expression patterns. This in polygenic traits may allow for better diagnosis...
Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. We studied Slit Trk-like 1 (SLITRK1) as candidate gene on chromosome 13q31.1 because of its proximity to de novo chromosomal inversion in child with TS. Among 174 unrelated probands, we identified frameshift mutation two independent occurrences the identical variant binding site for microRNA hsa-miR-189. These variants were absent from 3600 control...
Genetic Clues to Meningioma Meningiomas are the most common primary brain tumors in adults. Located within layer of tissue covering brain, these usually slow-growing and benign but can cause serious neurological complications. About half have mutations neurofibromin 2 gene ( NF2 ). To identify other genes that contribute meningioma pathogenesis, Clark et al. (p. 1077 , published online 24 January) performed genome sequence analysis on 300 tumors. fell into two general classes: located at...
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes us uniquely human. development the a highly complex process, this process reliant on precise regulation molecular cellular events grounded in spatiotemporal transcriptome. Disruption can lead to neuropsychiatric disorders. RATIONALE regulatory, epigenomic, transcriptomic features human have not been comprehensively compiled across time, regions, or cell types. Understanding etiology disorders requires...
Abstract Background Autism spectrum disorders (ASD) are early onset neurodevelopmental syndromes typified by impairments in reciprocal social interaction and communication, accompanied restricted repetitive behaviors. While rare especially de novo genetic variation known to affect liability, whether common polymorphism plays a substantial role is an open question the relative contribution of genes environment contentious. It probable that contributions variation, as well environment, differs...
Tourette's syndrome is a common developmental neuropsychiatric disorder characterized by chronic motor and vocal tics. Despite strong genetic contribution, inheritance complex, risk alleles have proven difficult to identify. Here, we describe an analysis of linkage in two-generation pedigree leading the identification rare functional mutation HDC gene encoding L-histidine decarboxylase, rate-limiting enzyme histamine biosynthesis. Our findings, together with previously published data from...