Matthew W. State

ORCID: 0000-0003-1624-8302
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About
Contact & Profiles
Research Areas
  • Autism Spectrum Disorder Research
  • Genetics and Neurodevelopmental Disorders
  • Genomic variations and chromosomal abnormalities
  • Congenital heart defects research
  • Obsessive-Compulsive Spectrum Disorders
  • Genomics and Rare Diseases
  • Genomics and Chromatin Dynamics
  • Genetic Associations and Epidemiology
  • Single-cell and spatial transcriptomics
  • Epigenetics and DNA Methylation
  • Chromosomal and Genetic Variations
  • Bioinformatics and Genomic Networks
  • Virology and Viral Diseases
  • Trypanosoma species research and implications
  • RNA modifications and cancer
  • Genetic Syndromes and Imprinting
  • Tryptophan and brain disorders
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • CRISPR and Genetic Engineering
  • Moyamoya disease diagnosis and treatment
  • Child Nutrition and Feeding Issues
  • Williams Syndrome Research
  • Health, Environment, Cognitive Aging
  • Cellular transport and secretion
  • RNA Research and Splicing

University of California, San Francisco
2016-2025

Spitalul Clinic Colentina
2023-2025

Carol Davila University of Medicine and Pharmacy
2023-2025

Langley Porter Psychiatric Hospital and Clinics
2014-2023

Quantitative BioSciences
2018-2023

Universidad Católica de Santa Fe
2023

Butler Hospital
2022

Hospital General Universitario Gregorio Marañón
2022

University of North Carolina at Chapel Hill
2021

University of Miami
2021

10.1038/nature13772 article EN Nature 2014-10-29
F. Kyle Satterstrom Jack A. Kosmicki Jiebiao Wang Michael S. Breen Silvia De Rubeis and 95 more Joon‐Yong An Minshi Peng Ryan L. Collins Jakob Grove Lambertus Klei Christine Stevens Jennifer Reichert Maureen Mulhern Mykyta Artomov Sherif Gerges Brooke Sheppard Xinyi Xu Aparna Bhaduri Utku Norman Harrison Brand Grace Schwartz Rachel Nguyen Elizabeth E. Guerrero Caroline Dias Catalina Betancur Edwin H. Cook Louise Gallagher Michael Gill James S. Sutcliffe Audrey Thurm Michael E. Zwick Anders D. Børglum Matthew W. State A. Ercüment Çiçek Michael E. Talkowski David J. Cutler Bernie Devlin Stephan Sanders Kathryn Roeder Mark J. Daly Joseph D. Buxbaum Branko Aleksić Richard Anney Mafalda Barbosa Somer Bishop Alfredo Brusco Jonas Bybjerg‐Grauholm Ángel Carracedo Marcus C.Y. Chan Andreas G. Chiocchetti Brian Hon‐Yin Chung Hilary Coon Michael L. Cuccaro Aurora Currò Bernardo Dalla Bernardina Ryan N. Doan Enrico Domenici Shan Dong Chiara Fallerini Montserrat Fernández Prieto Giovanni Battista Ferrero Christine M. Freitag Menachem Fromer J. Jay Gargus Daniel H. Geschwind Elisa Giorgio Javier González‐Peñas Stephen J. Guter Danielle Halpern Emily Hansen‐Kiss Xin He Gail E. Herman Irva Hertz‐Picciotto David M. Hougaard Christina M. Hultman Iuliana Ionita‐Laza Suma Jacob Jesslyn Jamison Astanand Jugessur Miia Kaartinen Gun Peggy Knudsen Alexander Kolevzon Itaru Kushima So Lun Lee Terho Lehtimäki Elaine T. Lim Carla Lintas W. Ian Lipkin Diego Lopergolo Fátima Lopes Yunin Ludeña Patrı́cia Maciel Per Magnus Behrang Mahjani Nell Maltman Dara S. Manoach Gal Meiri Idan Menashe Judith Miller Nancy J. Minshew

10.1016/j.cell.2019.12.036 article EN publisher-specific-oa Cell 2020-01-23
Peter Szatmari Andrew D. Paterson Lonnie Zwaigenbaum Wendy Roberts Jessica Brian and 95 more Xiaoqing Liu John B. Vincent Jennifer Skaug Ann Thompson Lili Senman Lars Feuk Qian Cheng Susan E. Bryson Marshall B. Jones Christian R. Marshall Stephen W. Scherer Veronica J. Vieland Christopher W. Bartlett La Vonne Mangin Rhinda Goedken Alberto M. Segre Margaret A. Pericak‐Vance Michael L. Cuccaro John R. Gilbert Harry H. Wright Ruth K. Abramson Catalina Betancur Thomas Bourgeron Christopher Gillberg Marion Leboyer Joseph D. Buxbaum Kenneth L. Davis Eric Hollander Jeremy M. Silverman Joachim Hallmayer Linda Lotspeich James S. Sutcliffe Jonathan L. Haines Susan E. Folstein Joseph Piven Thomas H. Wassink Val C. Sheffield Daniel H. Geschwind Maja Bućan W. Ted Brown Rita M. Cantor John N. Constantino T. Conrad Gilliam Martha R. Herbert Clara Lajonchere David H. Ledbetter Christa Lese‐Martin Janet Miller Stan F. Nelson Carol A Samango-Sprouse Sarah Spence Matthew W. State Rudolph E. Tanzi Hilary Coon Géraldine Dawson Bernie Devlin Annette Estes Pamela Flodman Lambertus Klei William M. McMahon Nancy J. Minshew Jeff Munson Elena Korvatska Patricia M. Rodier Gerard D. Schellenberg Moyra Smith M. Anne Spence Chris Stodgell Ping G. Tepper Ellen M. Wijsman Chang-En Yu Bernadette Rogé Carine Mantoulan Kerstin Wittemeyer Annemarie Poustka Bärbel Felder Sabine M. Klauck Claudia Schuster Fritz Poustka Sven Bölte Sabine Feineis-Matthews Evelyn Herbrecht Gabi Schmötzer John Tsiantis Κaterina Papanikolaou Elena Maestrini Elena Bacchelli Francesca Blasi Simona Carone Claudio Toma Hermán van Engeland Maretha Jonge Chantal Kemner Frederieke Koop Frederike Koop

10.1038/ng1985 article EN Nature Genetics 2007-02-18

Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which genetic underpinnings these diseases differ or is unknown. Gandal et al. performed meta-analyses transcriptomic covering five major disorders and compared cases controls identify coexpressed gene modules. From this, they found that some share global expression patterns. This in polygenic traits may allow for better diagnosis...

10.1126/science.aad6469 article EN Science 2018-02-09

Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. We studied Slit Trk-like 1 (SLITRK1) as candidate gene on chromosome 13q31.1 because of its proximity to de novo chromosomal inversion in child with TS. Among 174 unrelated probands, we identified frameshift mutation two independent occurrences the identical variant binding site for microRNA hsa-miR-189. These variants were absent from 3600 control...

10.1126/science.1116502 article EN Science 2005-10-13

Genetic Clues to Meningioma Meningiomas are the most common primary brain tumors in adults. Located within layer of tissue covering brain, these usually slow-growing and benign but can cause serious neurological complications. About half have mutations neurofibromin 2 gene ( NF2 ). To identify other genes that contribute meningioma pathogenesis, Clark et al. (p. 1077 , published online 24 January) performed genome sequence analysis on 300 tumors. fell into two general classes: located at...

10.1126/science.1233009 article EN Science 2013-01-25
Mingfeng Li Gabriel Santpere Yuka Imamura Kawasawa Oleg V. Evgrafov Forrest O. Gulden and 95 more Sirisha Pochareddy Susan M. Sunkin Zhen Li Yurae Shin Ying Zhu André M. M. Sousa Donna M. Werling Robert R. Kitchen Hyo Jung Kang Mihovil Pletikos Jinmyung Choi Sydney Muchnik Xuming Xu Daifeng Wang Belén Lorente-Galdós Shuang Liu Paola Giusti‐Rodríguez Hyejung Won Christiaan de Leeuw Antonio F. Pardiñas Ming Hu Fulai Jin Yun Li Michael J. Owen Michael O’Donovan James Walters Daniëlle Posthuma Mark A. Reimers Pat Levitt Daniel R. Weinberger Thomas M. Hyde Joel E. Kleinman Daniel H. Geschwind Michael Hawrylycz Matthew W. State Stephan Sanders Patrick F. Sullivan Mark Gerstein Ed S. Lein James A. Knowles Nenad Šestan A. Jeremy Willsey Aaron Oldre Aaron Szafer Adrian Camarena Adriana Cherskov Alexander W. Charney Alexej Abyzov Alexey Kozlenkov Alexias Safi Allan R. Jones Allison E. Ashley‐Koch Amanda Ebbert Amanda J. Price Amanda Sekijima Amira Kefi Amy Bernard Anahita Amiri Andrea Sboner Andrew E. Clark Andrew E. Jaffe Andrew T.N. Tebbenkamp Andy J. Sodt Angie Guillozet‐Bongaarts Angus C. Nairn Anita Carey Anita Hüttner Ann Chervenak Anna Szekely Annie W. Shieh Arif Harmanci Barbara K. Lipska Becky C. Carlyle Ben W. Gregor Bibi Kassim Brooke Sheppard Candace Bichsel Chang-Gyu Hahn Chang-Kyu Lee Chao Chen Chihchau L. Kuan Chinh Dang Chris Lau Christine Cuhaciyan Christoper Armoskus Christopher E. Mason Chunyu Liu Cliff Slaughterbeck Crissa Bennet Dalila Pinto Damon Polioudakis Daniel Franjic Daniel J. Miller Darren Bertagnolli David A. Lewis

INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes us uniquely human. development the a highly complex process, this process reliant on precise regulation molecular cellular events grounded in spatiotemporal transcriptome. Disruption can lead to neuropsychiatric disorders. RATIONALE regulatory, epigenomic, transcriptomic features human have not been comprehensively compiled across time, regions, or cell types. Understanding etiology disorders requires...

10.1126/science.aat7615 article EN Science 2018-12-14

Abstract Background Autism spectrum disorders (ASD) are early onset neurodevelopmental syndromes typified by impairments in reciprocal social interaction and communication, accompanied restricted repetitive behaviors. While rare especially de novo genetic variation known to affect liability, whether common polymorphism plays a substantial role is an open question the relative contribution of genes environment contentious. It probable that contributions variation, as well environment, differs...

10.1186/2040-2392-3-9 article EN cc-by Molecular Autism 2012-10-15

Tourette's syndrome is a common developmental neuropsychiatric disorder characterized by chronic motor and vocal tics. Despite strong genetic contribution, inheritance complex, risk alleles have proven difficult to identify. Here, we describe an analysis of linkage in two-generation pedigree leading the identification rare functional mutation HDC gene encoding L-histidine decarboxylase, rate-limiting enzyme histamine biosynthesis. Our findings, together with previously published data from...

10.1056/nejmoa0907006 article EN New England Journal of Medicine 2010-05-06
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