Jennifer L. Moran
A5058482061- Genetic Associations and Epidemiology
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Bipolar Disorder and Treatment
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Tuberculosis Research and Epidemiology
- RNA Research and Splicing
- Genetic Mapping and Diversity in Plants and Animals
- Autism Spectrum Disorder Research
- Acute Ischemic Stroke Management
- Blood disorders and treatments
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Schizophrenia research and treatment
- Gene expression and cancer classification
- Diet and metabolism studies
- Ubiquitin and proteasome pathways
- Bioinformatics and Genomic Networks
- RNA and protein synthesis mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Attention Deficit Hyperactivity Disorder
Broad Institute
2014-2024
MRC Protein Phosphorylation and Ubiquitylation Unit
2017-2024
University of Dundee
2009-2024
Lankenau Medical Center
2024
Massachusetts General Hospital
2012-2022
Genomics (United Kingdom)
2021
Icahn School of Medicine at Mount Sinai
2012-2020
Rush University
2020
Respiratory Health Association
2020
St George's Hospital
2020
Cancers arise from multiple acquired mutations, which presumably occur over many years. Early stages in cancer development might be present years before cancers become clinically apparent.
Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which genetic underpinnings these diseases differ or is unknown. Gandal et al. performed meta-analyses transcriptomic covering five major disorders and compared cases controls identify coexpressed gene modules. From this, they found that some share global expression patterns. This in polygenic traits may allow for better diagnosis...
A small number of rare, recurrent genomic copy variants (CNVs) are known to substantially increase susceptibility schizophrenia. As a consequence the low fecundity in people with schizophrenia and other neurodevelopmental phenotypes which these CNVs contribute, large effects on risk likely be rapidly removed from population by natural selection. Accordingly, such must frequently occur as de novo mutations. In sample 662 proband-parent trios, we found that rare CNV mutations were...
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation AGC (protein kinase A/protein G/protein C) family kinases such as Akt B), S6K (p70 ribosomal S6 kinase) SGK (serum glucocorticoid protein kinase). mTORC1 (mTOR complex-1) phosphorylates the hydrophobic motif S6K, whereas mTORC2 SGK. In present paper we describe small molecule Ku-0063794, which inhibits both with an IC50 ∼10 nM, but does not suppress activity 76 other or seven lipid...
A number of copy variants (CNVs) have been suggested as susceptibility factors for schizophrenia. For some these the data remain equivocal, and frequency in individuals with schizophrenia is uncertain.
Several recurrent copy number variants (CNVs) have been shown to increase the risk of developing schizophrenia (SCZ), developmental delay (DD), autism spectrum disorders (ASD), and various congenital malformations (CM). Their penetrance for SCZ has estimated be modest. However, comparisons between their or DD/ASD/CM, estimates total any these not yet made.
We sought to obtain novel insights into schizophrenia pathogenesis by exploiting the association between disorder and chromosomal copy number (CNV) burden. combined data from 5,745 cases 10,675 controls with other published datasets containing genome-wide CNV data. In this much-enlarged sample of 11,355 16,416 controls, we show for first time that case CNVs are enriched genes involved in GABAergic neurotransmission. Consistent non-genetic reports deficits schizophrenia, our findings now...
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of school-age children and 2.5% adults. Common genetic variants contribute substantially to ADHD susceptibility, but no individual have been robustly associated with ADHD. We report genome-wide association meta-analysis 20,183 cases 35,191 controls that identifies surpassing significance in 12 independent loci, revealing new important information on the underlying biology...
Abstract We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was with prior results Psychiatric Genomics Consortium Working Group combined sample 13 902 19 279 controls. identified eight significant, associated regions, including novel region on chromosome 10 (rs10884920; P =3.28 × −8 ) that includes brain-enriched cytoskeleton protein adducin 3 ( ADD3),...
Large (>100 kb), rare (<1% in the population) copy number variants (CNVs) have been shown to confer risk for schizophrenia (SZ), but findings bipolar disorder (BD) are less clear. In a new BD sample from United Kingdom (n=2591), we examined occurrence of CNVs and compared this with previously reported samples 6882 SZ 8842 control subjects. When combined previous data, find evidence contribution three SZ-associated CNV loci: duplications at 1q21.1 (P=0.022), deletions 3q29 (P=0.03) 16p11.2...