A5008056610- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Mental Health Treatment and Access
- Treatment of Major Depression
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Associations and Epidemiology
- Pharmaceutical Practices and Patient Outcomes
- Mental Health Research Topics
- Psychosomatic Disorders and Their Treatments
- Clinical practice guidelines implementation
- Substance Abuse Treatment and Outcomes
- Electronic Health Records Systems
- Pharmacology and Obesity Treatment
- Primary Care and Health Outcomes
- Health Sciences Research and Education
- Patient Safety and Medication Errors
- Genomic variations and chromosomal abnormalities
- Healthcare cost, quality, practices
- Health and Medical Research Impacts
- Posttraumatic Stress Disorder Research
- Innovations in Medical Education
- Obsessive-Compulsive Spectrum Disorders
- Traumatic Brain Injury Research
Stony Brook University
2015-2025
American Psychiatric Association
2005-2024
American College of Surgeons
2024
National Association of Community Health Centers
2024
University of Minnesota
2024
Centers for Disease Control and Prevention
2024
Optum (United States)
2024
Thomas Jefferson University
2024
Rush University Medical Center
2024
Feinstein Institute for Medical Research
2020-2022
V Resumen
Diagnostic shifts have been prospectively examined in the short term, but long-term stability of diagnoses has rarely evaluated. The authors diagnostic over a 10-year follow-up period.A cohort 470 first-admission patients with psychotic disorders was systematically assessed at baseline and 6-month, 2-year, follow-ups. Longitudinal best-estimate consensus were formulated after each assessment.At baseline, distribution 29.6% schizophrenia spectrum disorders, 21.1% bipolar disorder features,...
Abstract We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was with prior results Psychiatric Genomics Consortium Working Group combined sample 13 902 19 279 controls. identified eight significant, associated regions, including novel region on chromosome 10 (rs10884920; P =3.28 × −8 ) that includes brain-enriched cytoskeleton protein adducin 3 ( ADD3),...
We present an overview of the literature on patterns mental health service use and unmet need for care in individuals with schizophrenia a focus studies United States. also new data longitudinal course treatments from study first-admission patients schizophrenia. In epidemiological surveys, approximately 40% respondents report that they have not received any preceding 6-12 months. Clinical find many virtually drop out treatment after their index contact services receive little subsequent...
It remains uncertain whether people with psychotic disorders experience progressive cognitive decline or normal aging after first hospitalization. This information is essential for prognostication in clinical settings, deployment of remediation, and public health policy.To examine long-term changes individuals to compare age-related differences performance between matched control (ie, who had never disorders).The Suffolk County Mental Health Project an inception cohort study first-admission...
Schizophrenia is a common, chronic and debilitating neuropsychiatric syndrome affecting tens of millions individuals worldwide. While rare genetic variants play role in the etiology schizophrenia, most currently explained liability within common variation, suggesting that variation predating human diaspora out Africa harbors large fraction variant attributable heritability. However, association studies schizophrenia have concentrated mainly on cohorts European descent. We describe...
Kraepelin considered declining course a hallmark of schizophrenia, but others have suggested that outcomes usually stabilize or improve after treatment initiation. The authors investigated this question in an epidemiologically defined cohort with psychotic disorders followed for 20 years first hospitalization.
Abstract Understanding whether and how the schizophrenia polygenic risk score (SZ PRS) predicts course of illness could improve diagnosis prognostication in psychotic disorders. We tested SZ PRS symptoms, cognition, severity, diagnostic changes over 20 years following first admission. The Suffolk County Mental Health Project is an inception cohort study first-admission patients with psychosis. Patients were assessed six times years, 249 provided DNA. Geographically- demographically-matched...
This study examined the lifetime prevalence of trauma exposure and posttraumatic stress disorder (PTSD) their demographic, diagnostic, trauma-related correlates in a clinical cohort 426 patients with first psychiatric admission for psychosis. The was 68.5%. Female gender substance abuse were risk factors exposure. PTSD 14.3% full sample 26.5% those less prevalent bipolar schizophrenia twice as common women. Other significant younger age that repeated ongoing or involved childhood...
Knowing the long-term outcomes of schizophrenia and stability a diagnosis are important from clinical standpoint as well essential to future research on diagnostic classifications outcome. As in prior schizophrenia, prospectively designed studies over past 30 years find that predominant course illness includes chronically poor functioning, with little evidence improvement. Mortality due suicide is significant at about 10% 10-year periods follow-up. Within studies, outcome domains...
Background: Prior studies of common disorders in community-dwelling adults identified internalizing and externalizing spectra mental illness. We investigated the placement schizophrenia schizotypal personality disorder this framework tested validity resulting organization a clinical population. Methods: The data came from Suffolk County Mental Health Project cohort (N = 628), which consists first-admission patients with psychosis recruited inpatient units throughout County, NY (72% response...
Objective: At first hospitalization, a long duration of untreated psychosis (DUP) predicts illness severity and worse treatment outcomes. The mechanism this association, however, remains unclear. It has been hypothesized that lengthy is toxic or it reflects more severe form schizophrenia. Alternatively, the association may be an artifact lead-time bias. These hypotheses are tested in longitudinal study schizophrenia with 2,137 observations spanning from childhood to 20 years after admission....
Estimated glomerular filtration rate (eGFR) decline is associated with negative health outcomes, but the use of decision tree algorithms to predict eGFR underreported. Among patients hospitalized during first year COVID-19 pandemic, it remains unclear which individuals are at greatest risk after discharge. We conducted a retrospective cohort study on Stony Brook University Hospital in 2020 who were followed for 36 months post Random Forest (RF) identified top ten features fast decline....
Established nosology identifies schizoaffective disorder as a distinct category with boundaries separating it from mood disorders psychosis and schizophrenia. Alternative models argue for single boundary distinguishing schizophrenia (kraepelinian dichotomy) or continuous spectrum affective to nonaffective psychosis.To identify natural within psychotic by evaluating associations between symptom course long-term outcome.The Suffolk County Mental Health Project cohort consists of...
Objective There is an increased prevalence of obesity in schizophrenia and bipolar disorder, leading to a disproportionate risk adverse health conditions. Prospective, long‐term weight gain data, however, are scarce. Methods We analyzed data from the Suffolk County Mental Health Project cohort consecutive first admissions with psychosis recruited September 1989 December 1995 subsequently followed for 20 years, focusing on people (n=146) disorder (n=87). The time course was examined using 2...